370 research outputs found
The Insula of Reil Revisited: Multiarchitectonic Organization in Macaque Monkeys
The insula of Reil represents a large cortical territory buried in the depth of the lateral sulcus and subdivided into 3 major cytoarchitectonic domains: agranular, dysgranular, and granular. The present study aimed at reinvestigating the architectonic organization of the monkey's insula using multiple immunohistochemical stainings (parvalbumin, PV; nonphosphorylated neurofilament protein, with SMI-32; acetylcholinesterase, AChE) in addition to Nissl and myelin. According to changes in density and laminar distributions of the neurochemical markers, several zones were defined and related to 8 cytoarchitectonic subdivisions (Ia1-Ia2/Id1-Id3/Ig1-Ig2/G). Comparison of the different patterns of staining on unfolded maps of the insula revealed: 1) parallel ventral to dorsal gradients of increasing myelin, PV- and AChE-containing fibers in middle layers, and of SMI-32 pyramidal neurons in supragranular layers, with merging of dorsal and ventral high-density bands in posterior insula, 2) definition of an insula "proper” restricted to two-thirds of the "morphological” insula (as bounded by the limiting sulcus) and characterized most notably by lower PV, and 3) the insula proper is bordered along its dorsal, posterodorsal, and posteroventral margin by a strip of cortex extending beyond the limits of the morphological insula and continuous architectonically with frontoparietal and temporal opercular areas related to gustatory, somatosensory, and auditory modalitie
Interaction of vortices in viscous planar flows
We consider the inviscid limit for the two-dimensional incompressible
Navier-Stokes equation in the particular case where the initial flow is a
finite collection of point vortices. We suppose that the initial positions and
the circulations of the vortices do not depend on the viscosity parameter \nu,
and we choose a time T > 0 such that the Helmholtz-Kirchhoff point vortex
system is well-posed on the interval [0,T]. Under these assumptions, we prove
that the solution of the Navier-Stokes equation converges, as \nu -> 0, to a
superposition of Lamb-Oseen vortices whose centers evolve according to a
viscous regularization of the point vortex system. Convergence holds uniformly
in time, in a strong topology which allows to give an accurate description of
the asymptotic profile of each individual vortex. In particular, we compute to
leading order the deformations of the vortices due to mutual interactions. This
allows to estimate the self-interactions, which play an important role in the
convergence proof.Comment: 39 pages, 1 figur
The Camassa-Holm equation as the long-wave limit of the improved Boussinesq equation and of a class of nonlocal wave equations
In the present study we prove rigorously that in the long-wave limit, the
unidirectional solutions of a class of nonlocal wave equations to which the
improved Boussinesq equation belongs are well approximated by the solutions of
the Camassa-Holm equation over a long time scale. This general class of
nonlocal wave equations model bidirectional wave propagation in a nonlocally
and nonlinearly elastic medium whose constitutive equation is given by a
convolution integral. To justify the Camassa-Holm approximation we show that
approximation errors remain small over a long time interval. To be more
precise, we obtain error estimates in terms of two independent, small, positive
parameters and measuring the effect of nonlinearity and
dispersion, respectively. We further show that similar conclusions are also
valid for the lower order approximations: the Benjamin-Bona-Mahony
approximation and the Korteweg-de Vries approximation.Comment: 24 pages, to appear in Discrete and Continuous Dynamical System
Risk Factors for Mortality after COVID-19 in Patients with Preexisting Interstitial Lung Disease.
International audienc
Large time existence for 3D water-waves and asymptotics
We rigorously justify in 3D the main asymptotic models used in coastal
oceanography, including: shallow-water equations, Boussinesq systems,
Kadomtsev-Petviashvili (KP) approximation, Green-Naghdi equations, Serre
approximation and full-dispersion model. We first introduce a ``variable''
nondimensionalized version of the water-waves equations which vary from shallow
to deep water, and which involves four dimensionless parameters. Using a
nonlocal energy adapted to the equations, we can prove a well-posedness
theorem, uniformly with respect to all the parameters. Its validity ranges
therefore from shallow to deep-water, from small to large surface and bottom
variations, and from fully to weakly transverse waves. The physical regimes
corresponding to the aforementioned models can therefore be studied as
particular cases; it turns out that the existence time and the energy bounds
given by the theorem are always those needed to justify the asymptotic models.
We can therefore derive and justify them in a systematic way.Comment: Revised version of arXiv:math.AP/0702015 (notations simplified and
remarks added) To appear in Inventione
Lipopolysaccharide (LPS)-binding protein in human serum determines the tumor necrosis factor response of monocytes to LPS
Lipopolysaccharide (LPS)-binding protein (LBP) and CD14 represent key elements in monocyte activation by LPS. The mean concentration of LBP was 18.1 microgram/mL in normal serum and 40-60 micrograms/mL in serum of patients with septic shock, independent of the fact that patients had gram-negative or other infections. Ten percent normal serum presented large concentrations of LPS (in the microgram range) to monocytes. Only when diluted 1:100 was LBP in plasma a limiting factor for monocyte activation, as measured by tumor necrosis factor (TNF) release. When LBP was depleted from serum with anti-LBP antibodies, the resulting serum did not support TNF release of monocytes upon LPS challenge. In conclusion, monocyte activation resulting in TNF secretion was related to LBP, which is abundantly present in normal serum, and elevated two to three times in patients with septic shock
Bactericidal/Permeability-Increasing Protein Inhibits Induction of Macrophage Nitric Oxide Production by Lipopolysaccharide
Competition between Bactericidal/Permeability-Increasing Protein and Lipopolysaccharide-Binding Protein for Lipopolysaccharide Binding to Monocytes
Coherent vortex structures and 3D enstrophy cascade
Existence of 2D enstrophy cascade in a suitable mathematical setting, and
under suitable conditions compatible with 2D turbulence phenomenology, is known
both in the Fourier and in the physical scales. The goal of this paper is to
show that the same geometric condition preventing the formation of
singularities - 1/2-H\"older coherence of the vorticity direction - coupled
with a suitable condition on a modified Kraichnan scale, and under a certain
modulation assumption on evolution of the vorticity, leads to existence of 3D
enstrophy cascade in physical scales of the flow.Comment: 15 pp; final version -- to appear in CM
Modulational Instability in Equations of KdV Type
It is a matter of experience that nonlinear waves in dispersive media,
propagating primarily in one direction, may appear periodic in small space and
time scales, but their characteristics --- amplitude, phase, wave number, etc.
--- slowly vary in large space and time scales. In the 1970's, Whitham
developed an asymptotic (WKB) method to study the effects of small
"modulations" on nonlinear periodic wave trains. Since then, there has been a
great deal of work aiming at rigorously justifying the predictions from
Whitham's formal theory. We discuss recent advances in the mathematical
understanding of the dynamics, in particular, the instability of slowly
modulated wave trains for nonlinear dispersive equations of KdV type.Comment: 40 pages. To appear in upcoming title in Lecture Notes in Physic
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