Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons

Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process. A large body of data indicates that opioids and dopamine together mediate emotional and reinforced behaviors. In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of δ-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons. To further define cellular mechanisms underlying this effect, the subcellular distribution of DOR and D1R was examined in the rat dorsolateral striatum. Dual immunoperoxidase/gold-silver detection combined with electron microscopy was used to identify DOR and D1R immunoreactivities in the same section of tissue. Semi-quantitative analysis revealed that a subset of dendritic cellular profiles exhibited both DOR and D1R immunoreactivities. Of 165 randomly sampled D1R immunoreactive profiles, 43% contained DOR. Similarly of 198 DOR-labeled cellular profiles, 52% contained D1R. The present data provide ultrastructural evidence for co-existence between DOR and D1R in striatal neurons, suggesting a possible mechanism whereby D1R modulation may alter DOR function

Investigating the Structure of the Windy Torus in Quasars

Thermal mid-infrared emission of quasars requires an obscuring structure that can be modeled as a magneto-hydrodynamic wind in which radiation pressure on dust shapes the outflow. We have taken the dusty wind models presented by Keating and collaborators that generated quasar mid-infrared spectral energy distributions (SEDs), and explored their properties (such as geometry, opening angle, and ionic column densities) as a function of Eddington ratio and X-ray weakness. In addition, we present new models with a range of magnetic field strengths and column densities of the dust-free shielding gas interior to the dusty wind. We find this family of models -- with input parameters tuned to accurately match the observed mid-IR power in quasar SEDs -- provides reasonable values of the Type 1 fraction of quasars and the column densities of warm absorber gas, though it does not explain a purely luminosity-dependent covering fraction for either. Furthermore, we provide predictions of the cumulative distribution of E(B-V) values of quasars from extinction by the wind and the shape of the wind as imaged in the mid-infrared. Within the framework of this model, we predict that the strength of the near-infrared bump from hot dust emission will be correlated primarily with L/L_Edd rather than luminosity alone, with scatter induced by the distribution of magnetic field strengths. The empirical successes and shortcomings of these models warrant further investigations into the composition and behaviour of dust and the nature of magnetic fields in the vicinity of actively accreting supermassive black holes.Comment: 11 pages, 6 figures, accepted for publication in MNRA

BoostNet: Bootstrapping detection of socialbots, and a case study from Guatemala

We present a method to reconstruct networks of socialbots given minimal input. Then we use Kernel Density Estimates of Botometer scores from 47,000 social networking accounts to find clusters of automated accounts, discovering over 5,000 socialbots. This statistical and data driven approach allows for inference of thresholds for socialbot detection, as illustrated in a case study we present from Guatemala.Comment: 7 pages, 4 figure

Impingement of Water Droplets on NACA 65A004 Airfoil at 8 deg Angle of Attack

The trajectories of droplets in the air flowing past an NACA 65AO04 airfoil at an angle of attack of 8 deg were determined.. The amount of water in droplet form impinging on the airfoil, the area of droplet impingement, and the rate of droplet impingement per unit area on the airfoil surface were calculated from the trajectories and presented to cover a large range of flight and atmospheric conditions. These impingement characteristics are compared briefly with those previously reported for the same airfoil at an angle of attack of 4 deg

Spatiotemporal dynamics of quantum jumps with Rydberg atoms

We study the nonequilibrium dynamics of quantum jumps in a one-dimensional chain of atoms. Each atom is driven on a strong transition to a short-lived state and on a weak transition to a metastable state. We choose the metastable state to be a Rydberg state so that when an atom jumps to the Rydberg state, it inhibits or enhances jumps in the neighboring atoms. This leads to rich spatiotemporal dynamics that are visible in the fluorescence of the strong transition.Comment: 10 page

An in-depth spectroscopic examination of molecular bands from 3D hydrodynamical model atmospheres I. Formation of the G-band in metal-poor dwarf stars

Recent developments in the three-dimensional (3D) spectral synthesis code Linfor3D have meant that, for the first time, large spectral wavelength regions, such as molecular bands, can be synthesised with it in a short amount of time. A detailed spectral analysis of the synthetic G-band for several dwarf turn-off-type 3D atmospheres (5850 <= T_eff [K] <= 6550, 4.0 <= log g <= 4.5, -3.0 <= [Fe/H] <= -1.0) was conducted, under the assumption of local thermodynamic equilibrium. We also examine carbon and oxygen molecule formation at various metallicity regimes and discuss the impact it has on the G-band. Using a qualitative approach, we describe the different behaviours between the 3D atmospheres and the traditional one-dimensional (1D) atmospheres and how the different physics involved inevitably leads to abundance corrections, which differ over varying metallicities. Spectra computed in 1D were fit to every 3D spectrum to determine the 3D abundance correction. Early analysis revealed that the CH molecules that make up the G-band exhibited an oxygen abundance dependency; a higher oxygen abundance leads to weaker CH features. Nitrogen abundances showed zero impact to CH formation. The 3D corrections are also stronger at lower metallicity. Analysis of the 3D corrections to the G-band allows us to assign estimations of the 3D abundance correction to most dwarf stars presented in the literature. The 3D corrections suggest that A(C) in CEMP stars with high A(C) would remain unchanged, but would decrease in CEMP stars with lower A(C). It was found that the C/O ratio is an important parameter to the G-band in 3D. Additional testing confirmed that the C/O ratio is an equally important parameter for OH transitions under 3D. This presents a clear interrelation between the carbon and oxygen abundances in 3D atmospheres through their molecular species, which is not seen in 1D.Comment: 19 pages, 13 figures, 4 tables. Accepted for publication in A&

Collective quantum jumps of Rydberg atoms

We study an open quantum system of atoms with long-range Rydberg interaction, laser driving, and spontaneous emission. Over time, the system occasionally jumps between a state of low Rydberg population and a state of high Rydberg population. The jumps are inherently collective and in fact exist only for a large number of atoms. We explain how entanglement and quantum measurement enable the jumps, which are otherwise classically forbidden.Comment: 4 page

Mean age gradient and asymmetry in the star formation history of the Small Magellanic Cloud

We derive the star formation history in four regions of the Small Magellanic Cloud (SMC) using the deepest VI color-magnitude diagrams (CMDs) ever obtained for this galaxy. The images were obtained with the Advanced Camera for Surveys onboard the Hubble Space Telescope and are located at projected distances of 0.5-2 degrees from the SMC center, probing the main body and the wing of the galaxy. We derived the star-formation histories (SFH) of the four fields using two independent procedures to fit synthetic CMDs to the data. We compare the SFHs derived here with our earlier results for the SMC bar to create a deep pencil-beam survey of the global history of the central SMC. We find in all the six fields observed with HST a slow star formation pace from 13 to 5-7 Gyr ago, followed by a ~ 2-3 times higher activity. This is remarkable because dynamical models do not predict a strong influence of either the LMC or the Milky Way (MW) at that time. The level of the intermediate-age SFR enhancement systematically increases towards the center, resulting in a gradient in the mean age of the population, with the bar fields being systematically younger than the outer ones. Star formation over the most recent 500 Myr is strongly concentrated in the bar, the only exception being the area of the SMC wing. The strong current activity of the latter is likely driven by interaction with the LMC. At a given age, there is no significant difference in metallicity between the inner and outer fields, implying that metals are well mixed throughout the SMC. The age-metallicity relations we infer from our best fitting models are monotonically increasing with time, with no evidence of dips. This may argue against the major merger scenario proposed by Tsujimoto and Bekki 2009, although a minor merger cannot be ruled out.Comment: 30 pages, 16 figures, accepted for publication in Ap