Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Congenital Anomalies: A Retrospective Cohort Study

BACKGROUND: Prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk of certain congenital anomalies among exposed offspring. OBJECTIVES: This retrospective cohort study examined whether PCE contamination of public drinking water supplies in Massachusetts influenced the occurrence of congenital anomalies among children whose mothers were exposed around the time of conception. METHODS: The study included 1,658 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 2,999 children of unexposed mothers. Mothers completed a self-administered questionnaire to gather information on all of their prior births, including the presence of anomalies, residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: Children whose mothers had high exposure levels around the time of conception had an increased risk of congenital anomalies. The adjusted odds ratio of all anomalies combined among children with prenatal exposure in the uppermost quartile was 1.5 (95% CI: 0.9, 2.5). No meaningful increases in the risk were seen for lower exposure levels. Increases were also observed in the risk of neural tube defects (OR: 3.5, 95% CI: 0.8, 14.0) and oral clefts (OR 3.2, 95% CI: 0.7, 15.0) among offspring with any prenatal exposure. CONCLUSION: The results of this study suggest that the risk of certain congenital anomalies is increased among the offspring of women who were exposed to PCE-contaminated drinking water around the time of conception. Because these results are limited by the small number of children with congenital anomalies that were based on maternal reports, a follow-up investigation should be conducted with a larger number of affected children who are identified by independent records.National Institute of Environmental Health (5 P42 ES007381); National Institutes of Healt

Pilot-Scale Modeling of Colloidal Silica Delivery to Liquefiable Sands

Passive site stabilization is a developing technology for in situ mitigation of liquefaction risk without surface disruption and involves slow injection of stabilizing materials into the liquefiable sand. In this study, colloidal silica injection was performed in a pilot-scale facility having dimensions of 243 cm by 366 cm in plan and 122 cm in depth. The pilot-scale facility is the largest of its kind in the United States. It is equipped with electrical conductivity cells which provide real-time monitoring of grout advancement in the soil. Injection rates ranging between 135 and 9000 ml/min/well were used to investigate the optimal rate for grout delivery. In low injection rates, colloidal silica sank instead of traveling horizontally. With higher injection rates, sinking was less noticeable. After treatment, the model was excavated and soil samples were extracted to investigate the grout penetration. Soil recovered from block samples was tested for unconfined strength in the laboratory. The 3D flood simulator UTCHEM was used to simulate the experimental results. The results of actual experiments showed that even 1% percentage colloidal silica provides significant strength after a month of curing

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity.

Most Pacific salmonids undergo smoltification and transition from freshwater to saltwater, making various adjustments in metabolism, catabolism, osmotic, and ion regulation. The molecular mechanisms underlying this transition are largely unknown. In the present study, we acclimated coho salmon (Oncorhynchus kisutch) to four different salinities and assessed gene expression through microarray analysis of gills, liver, and olfactory rosettes. Gills are involved in osmotic regulation, liver plays a role in energetics, and olfactory rosettes are involved in behavior. Between all salinity treatments, liver had the highest number of differentially expressed genes at 1616, gills had 1074, and olfactory rosettes had 924, using a 1.5-fold cutoff and a false discovery rate of 0.5. Higher responsiveness of liver to metabolic changes after salinity acclimation to provide energy for other osmoregulatory tissues such as the gills may explain the differences in number of differentially expressed genes. Differentially expressed genes were tissue- and salinity-dependent. There were no known genes differentially expressed that were common to all salinity treatments and all tissues. Gene ontology term analysis revealed biological processes, molecular functions, and cellular components that were significantly affected by salinity, a majority of which were tissue-dependent. For liver, oxygen binding and transport terms were highlighted. For gills, muscle, and cytoskeleton-related terms predominated and for olfactory rosettes, immune response-related genes were accentuated. Interaction networks were examined in combination with GO terms and determined similarities between tissues for potential osmosensors, signal transduction cascades, and transcription factors

Stabilization of liquefiable soils using colloidal silica grout

Journal of Materials in Civil Engineering, 19(1): pp. 33-40.Passive site stabilization is a new technology proposed for nondisruptive mitigation of liquefaction risk at developed sites susceptible to liquefaction. It is based on the concept of slowly injecting colloidal silica at the edge of a site with subsequent delivery to the target location using natural or augmented groundwater flow. Colloidal silica is an aqueous dispersion of silica nanoparticles that can be made to gel by adjusting the pH or salt concentration of the dispersion. It stabilizes liquefiable soils by cementing individual grains together in addition to reducing the hydraulic conductivity of the formation. Centrifuge modeling was used to investigate the effect of colloidal silica treatment on the liquefaction and deformation resistance of loose, liquefiable sands during centrifuge in-flight shaking. Loose sand was successfully saturated with colloidal silica grout and subsequently subjected to two shaking events to evaluate the response of the treated sand layer. The treated soil did not liquefy during either shaking event. In addition, a box model was used to investigate the ability to uniformly deliver colloidal silica to loose sands using low-head injection wells. Five injection and two extraction wells were used to deliver stabilizer in a fairly uniform pattern to the loose sand formation. The results of the box model testing will be used to design future centrifuge model tests modeling other delivery methods of the grout

HII Region Oxygen Abundances in Starbursting Transition Dwarf Galaxies

We present empirical HII region oxygen abundances for a sample of low-luminosity starburst galaxies which are in a short lived evolutionary state. All five galaxies are characterized by centrally concentrated star formation, which is embedded in smooth stellar envelopes resembling dE-like systems. The galaxies also have small gas contents with typical M_{HI}/L_{B} ~ 0.1 resulting in gas exhaustion timescales less than 1 Gyr, even when molecular gas is considered. We find, compared to other morphologically similar systems, the galaxies of this sample have surprisingly high oxygen abundances with 12 + log(O/H) ~ 9.0. We propose that these objects are a subclass of evolved blue compact dwarfs, which have exhausted most of their gas supply while retaining their metals. We further propose that we are seeing these objects during a short phase in which they are nearing the end of their starburst activity, and could become early-type dwarfs.Comment: 13 pages, 3 figures, accepted by ApJ Letter

Evolutionary Status of Dwarf ``Transition'' Galaxies

We present deep B, R and Halpha imaging of 3 dwarf galaxies: NGC3377A, NGC4286, and IC3475. Based on previous broadband imaging and HI studies, these mixed-morphology galaxies were proposed by Sandage & Hoffman (1991) to be, respectively, a gas-rich low surface brightness Im dwarf, a nucleated dwarf that has lost most of its gas and is in transition from Im to dS0,N, and the prototypical example of a gas-poor ``huge low surface brightness'' early-type galaxy. From the combination of our broadband and Halpha imaging with the published information on the neutral gas content of these three galaxies, we find that (1) NGC3377A is a dwarf spiral; (2) NGC3377A and NGC4286 have comparable amounts of ongoing star formation, as indicated by their Halpha emission, while IC3475 has no detected HII regions to a very low limit; (3) the global star formation rates are at least a factor of 20 below that of 30 Doradus for NGC3377A and NGC4286; (4) while the amount of star formation is comparable, the distribution of star forming regions is very different between NGC3377A and NGC4286; (5) given their current star formation rates and gas contents, both NGC3377A and NGC4286 can continue to form stars for more than a Hubble time; (6) both NGC3377A and NGC4286 have integrated total B-R colors that are redder than the integrated total B-R color for IC3475, and thus it is unlikely that either galaxy will ever evolve into an IC3475 counterpart; and (7) IC3475 is too blue to be a dE. We thus conclude that we have not identified potential precursors to galaxies such as IC3475, and unless signifcant changes occur in the star formation rates, neither NGC3377A nor NGC4286 will evolve into a dwarf elliptical or dwarf spheroidal within a Hubble time.Comment: 34 pages, 6 jpg figures, 3 postscript figures, and 4 tables, uses AASTeX, ApJ, in pres

Laboratory evaluation of crushed glass dredged material blends

Journal of Geotechnical and Geoenvironmental Engineering, 132(5): pp. 562-576.A comprehensive laboratory evaluation of blending 9.5 mm 3/8 in. minus curbside-collected crushed glass CG with dredged material DM was conducted to evaluate their potential for beneficial use as fill materials for urban applications. Tests were performed on 100% CG USCS classification SP and 100% DM OH specimens and 20/ 80, 40/ 60, 50/ 50, 60/ 40, and 80/20 CG–DM blends dry weight percent CG content reported first . The addition of 20% CG resulted in a 10–20 point 33–67% reduction in wopt while increasing the dry density by approximately 1–3 kN/m3 for standard and modified levels of compaction, respectively. Simultaneously, the compressibility of the DM was reduced by approximately 50% and the hydraulic conductivity was reduced by 1 2 order of magnitude. The addition of 20% CG significantly decreased the moisture content and significantly improved the workability of the 100% DM, where workability refers to the ease of handling, transport, placement, and compaction of the CG–DM blends compared to 100% DM . CIŪ triaxial strength testing indicated effective friction angles of 34 and 37° for 100% DM and CG compacted to a minimum of 95% relative compaction by ASTM D1557, respectively. A peak effective friction angle of 39° occurred for the 60/40 and 80/20 CG–DM blends which were also 1 and 3 orders of magnitude more permeable than 100% DM, respectively. Related increases in cv resulted in decreased times required for consolidation. The range of properties obtainable by the CG–DM blends offers a versatility that allows for the design of fills that can be potentially optimized to meet multiple design parameters e.g. strength, settlement, drainage, or higher CG or DM content