Using Problem-based Learning to Explore Unseen Academic Potential

One goal of the US Department of Education-funded Project Insights was to see if the use of Problem-based Learning (PBL) would encourage students to reveal previously unseen academic potential. Two PBL units were taught to 271 sixth grade students in 13 classrooms. Afterwards, teachers identified students who demonstrated previously unseen academic potential during the PBL units. This advanced academic potential group was compared with students identified as gifted using district criteria and the remaining sixth grade students. Measures included standardized achievement test scores, teacher ratings of students’ engagement in PBL, and independent ratings of students’ performance on specific PBL assignments. Results of comparisons support the teacher’s identification of the advanced academic potential students as a group distinct from both from the traditionally identified students and general education students. Findings suggest that a well-designed, engaging curriculum such as PBL can create learning context that encourages more students to reveal academic potential

Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved]

The purpose of an F1000 review is to reflect on the bigger picture, exploring controversies and new concepts as well as providing opinion as to what is limiting progress in a particular field. We reviewed about 200 titles published in 2015 that included reference to ‘skeletal muscle, exercise, and ageing’ with the aim of identifying key articles that help progress our understanding or research capacity while identifying methodological issues which represent, in our opinion, major barriers to progress. Loss of neuromuscular function with chronological age impacts on both health and quality of life. We prioritised articles that studied human skeletal muscle within the context of age or exercise and identified new molecular observations that may explain how muscle responds to exercise or age. An important aspect of this short review is perspective: providing a view on the likely ‘size effect’ of a potential mechanism on physiological capacity or ageing

Providing stringent star formation rate limits of z∼\sim2 QSO host galaxies at high angular resolution

We present integral field spectrograph (IFS) with laser guide star adaptive optics (LGS-AO) observations of z=2 quasi-stellar objects (QSOs) designed to resolve extended nebular line emission from the host galaxy. Our data was obtained with W. M. Keck and Gemini-North Observatories using OSIRIS and NIFS coupled with the LGS-AO systems. We have conducted a pilot survey of five QSOs, three observed with NIFS+AO and two observed with OSIRIS+AO at an average redshift of z=2.15. We demonstrate that the combination of AO and IFS provides the necessary spatial and spectral resolutions required to separate QSO emission from its host. We present our technique for generating a PSF from the broad-line region of the QSO and performing PSF subtraction of the QSO emission to detect the host galaxy. We detect H$\alpha$ and [NII] for two sources, SDSS J1029+6510 and SDSS J0925+06 that have both star formation and extended narrow-line emission. Assuming that the majority of narrow-line H$\alpha$ is from star formation, we infer a star formation rate for SDSS J1029+6510 of 78.4 M$_\odot$yr$^{-1}$ originating from a compact region that is kinematically offset by 290 - 350 km/s. For SDSS J0925+06 we infer a star formation rate of 29 M$_\odot$yr$^{-1}$ distributed over three clumps that are spatially offset by $\sim$ 7 kpc. The null detections on three of the QSOs are used to infer surface brightness limits and we find that at 1.4 kpc distance from the QSO that the un-reddened star formation limit is $<$ 0.3 M$_\odot$yr$^{-1}$kpc$^{-2}$. If we assume a typical extinction values for z=2 type-1 QSOs, the dereddened star formation rate for our null detections would be $<$ 0.6 M$_\odot$yr$^{-1}$kpc$^{-2}$. These IFS observations indicate that if star formation is present in the host it would have to occur diffusely with significant extinction and not in compact, clumpy regions.Comment: 17 pages, 7 figures, 7 tables, Accepted to Ap

Multiple sources of bias confound functional enrichment analysis of global -omics data

Serious and underappreciated sources of bias mean that extreme caution should be applied when using or interpreting functional enrichment analysis to validate findings from global RNA- or protein-expression analyses

The Role of Political Skill in the Stressor–Outcome Relationship: Differential Predictions for Self- and Other-Reports of Political Skill

The beneficial role of political skill in stress reactions and performance evaluations has been demonstrated in a substantial amount of empirical research. Most of the research, however, has focused on self-perceptions of political skill. This study examines the differential moderating effects of self- vs. other-rated political skill in the conflict – emotional burnout and performance relationships, using two samples including non-academic staff employees of a large university (N = 839) and a variety of office and retail employees from an automotive organization (N = 142). We argue that self-reported political skill moderates the relationship between conflict and a self-reported strain-related outcome that is important to the individual (i.e., emotional burnout), but that supervisor-rated political skill does not moderate this relationship. Further, we argue that supervisor-rated political skill moderates the relationship between conflict and an outcome important to the supervisor and the organization (i.e., job performance), but that self-reported political skill does not moderate this relationship. Findings partially support our hypotheses as both self and supervisor-rated political skill neutralized the negative effects of conflict on burnout, but only supervisor-rated political skill neutralized the negative effects of conflict on performance. Limitations and directions for future research are discussed

What does the arthropathy of alkaptonuria teach us about disease mechanisms in osteoarthritis and ageing of joints? Lessons from a rare disease

AKU Society, the Rosetrees Foundation, the Childwick Trust, the Big Lottery and EUFP