180 research outputs found

    Emerging Infectious Diseases

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    Description of infectious diseases emerging across the globe with explanation of factors contributing to emergence

    Instrumentation and Procedures for Validation of Synthetic Infrared Image Generation Models

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    Synthetic infrared image generation models are becoming more complex with the incorporation of radiation propagation, thermodynamic, environmental, energy matter interaction, and sensor models linked through ray tracers into CAD models of scenes. As these models evolve, it is becoming increasingly necessary and difficult to design validation experiments to determine how well the models work and where the limitations are. This paper describes an experimental approach to validation of the radiometric integrity of an end-to-end thermal infrared SIG model. The approach attempts to break down the overall SIG model into a set of submodels with measurable input and output parameters. A scene is then instrumented and imaged in a time lapse fashion over an extended period (e.g., 48 hours). This scene is also synthetically produced so that the actual and synthetic scenes can be compared. The experimental approach includes acquisition of meteorological data (air temperature, relative humidity, wind speed, cloud cover, precipitation type and rate, total insolation, diffuse insolation), object data (emissivity, absorptivity, thermal conductivity, specific heat, temperature), atmospheric data (transmission, path radiance) and image data (calibrated longwave infrared and midwave infrared images, as well as visible images). Error propagation models are used in conjunction with the experimental data to determine the source and relative importance of errors in the modeling process

    Union Commitment: Is There a Gender Gap?

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    Au cours des dernières décennies, la composition de la main-d’œuvre au Canada s'est nettement modifiée à cause de la croissance du pourcentage des femmes qui sont entrées et sont restées sur le marché du travail. Parallèlement à l'augmentation du taux de participation de la main-d’œuvre féminine, les femmes en sont venues à former une part de plus en plus grande de l'effectif syndical. La présente étude veut aller au-delà de la question de la propension des femmes à adhérer aux syndicats et comparer leurs comportements et ceux des hommes dans leur engagement respectif envers l'organisation qui les représente. Fondé sur un échantillon de 223 femmes et de 222 hommes, membres d'un syndicat, qui travaillent dans le commerce de gros et de détail de produits alimentaires ainsi que dans le secteur de la santé en Saskatchewan, nous cherchons à découvrir si les syndiquées sont aussi engagées dans les organisations syndicales locales que leurs collègues de sexe masculin.Cette enquête vise aussi à établir dans quelle mesure les facteurs que l'on associe généralement à l'engagement syndical sont les mêmes pour les femmes et pour les hommes. À partir des recherches antérieures touchant l'engagement syndical, nous en étudions ici trois dimensions spécifiques: 'la fidélité au syndicat', 'les obligations envers le syndicat' et 'la volonté de travailler pour le syndicat'. Nous avançons l'hypothèse que les différences entre les hommes et les femmes sont plus prononcées pour les formes d'engagement syndical qui requièrent un degré plus élevé d'action. En particulier, la plus grande divergence susceptible d'exister dans l'engagement syndical entre les sexes devrait se retrouver dans 'la volonté de travailler pour le syndicat' plutôt que dans la forme moins active des 'obligations' ou dans celle plus passive de 'la fidélité'.La comparaison des tests de moyennes révèle que les syndiquées se sont déclarées, de façon significative, plus loyales envers le syndicat que leurs collègues masculins. Cependant, les hommes ont exprimé dans une plus grande proportion leur intention de 'travailler' pour l'association syndicale locale. Aucune différence entre les employés des deux sexes quant aux 'obligations' envers le syndicat n'a été constatée. On a utilisé un modèle de régression multiple pour isoler l'influence de d'autres facteurs identifiés dans les recherches publiées sur l'engagement syndical. Les résultats révèlent que la variable sexe a un effet statistiquement significatif sur l'engagement syndical seulement pour la dimension 'volonté de travailler pour le syndicat'. Et bien que son effet soit significatif, cette variable n'explique qu'un pour cent de la variance totale pour ce qui a trait à cette dimension. Par ailleurs, l'analyse des autres facteurs associés à l'engagement syndical, tant pour les femmes que pour les hommes, n'indique qu'un écart minime. En résumé, les résultats suggèrent que le sexe est tout au plus un facteur mineur dans la détermination de l'une des trois dimensions étudiées de l'engagement syndical. De plus, la plupart des facteurs qui concourent à l'engagement syndical sont partagés tant par les membres masculins que féminins des organisations syndicales locales. Par rapport aux politiques syndicales, ces résultats font particulièrement ressortir l'importance des efforts des syndicats en vue de socialiser les nouveaux membres dès le début de l'adhésion et de se préoccuper de leurs besoins, sans égard à leur sexe. Pour les deux groupes, les expériences de socialisation dès le commencement de la syndicalisation sont très liées au degré d'engagement personnel dans l'organisation syndicale locale.In the context of the growing feminization of membership in Canadian labour unions, this study examines the relationship between gender and multiple dimensions of worker commitment to the union organization. Based upon survey responses from 223 female and 222 male union members in Saskatchewan, the results reveal no gender differences with regard to expressed levels of union "loyalty" and "responsibility to the union". However, a small but significantly lower level of "willingness to work for the union" was expressed by female union members. In comparative analyses of males and females, the results are generally supportive of greater commonality than differences in the correlates of union commitment for men and women

    Young Adult Smokers\u27 Neural Response to Graphic Cigarette Warning Labels

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    Introduction: The study examined young adult smokers\u27 neural response to graphic warning labels (GWLs) on cigarette packs using functional magnetic resonance imaging (fMRI). Methods: Nineteen young adult smokers (M age 22.9, 52.6% male, 68.4% non-white, M 4.3 cigarettes/day) completed pre-scan, self-report measures of demographics, cigarette smoking behavior, and nicotine dependence, and an fMRI scanning session. During the scanning session participants viewed cigarette pack images (total 64 stimuli, viewed 4 s each) that varied based on the warning label (graphic or visually occluded control) and pack branding (branded or plain packaging) in an event-related experimental design. Participants reported motivation to quit (MTQ) in response to each image using a push-button control. Whole-brain blood oxygenation level-dependent (BOLD) functional images were acquired during the task. Results: GWLs produced significantly greater self-reported MTQ than control warnings (p \u3c .001). Imaging data indicate stronger neural activation in response to GWLs than the control warnings at a cluster-corrected threshold p \u3c .001 in medial prefrontal cortex, amygdala, medial temporal lobe, and occipital cortex. There were no significant differences in response to warnings on branded versus plain cigarette packages. Conclusions: In this sample of young adult smokers, GWLs promoted neural activation in brain regions involved in cognitive and affective decision-making and memory formation and the effects of GWLs did not differ on branded or plain cigarette packaging. These findings complement other recent neuroimaging GWL studies conducted with older adult smokers and with adolescents by demonstrating similar patterns of neural activation in response to GWLs among young adult smokers

    Magnify is a universal molecular anchoring strategy for expansion microscopy

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    Expansion microscopy enables nanoimaging with conventional microscopes by physically and isotropically magnifying preserved biological specimens embedded in a crosslinked water-swellable hydrogel. Current expansion microscopy protocols require prior treatment with reactive anchoring chemicals to link specific labels and biomolecule classes to the gel. We describe a strategy called Magnify, which uses a mechanically sturdy gel that retains nucleic acids, proteins and lipids without the need for a separate anchoring step. Magnify expands biological specimens up to 11 times and facilitates imaging of cells and tissues with effectively around 25-nm resolution using a diffraction-limited objective lens of about 280 nm on conventional optical microscopes or with around 15 nm effective resolution if combined with super-resolution optical fluctuation imaging. We demonstrate Magnify on a broad range of biological specimens, providing insight into nanoscopic subcellular structures, including synaptic proteins from mouse brain, podocyte foot processes in formalin-fixed paraffin-embedded human kidney and defects in cilia and basal bodies in drug-treated human lung organoids

    Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum

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    Objective: To assess whether a weight management intervention for pregnant women with obesity was effective in reducing body mass index (BMI) 12 months after giving birth. Methods: Pragmatic, cluster randomised controlled trial (RCT) with embedded cost-effectiveness analysis. 598 women with a BMI of ≥30 kg/m2 (between 12 and 20 weeks gestation) were recruited from 20 secondary care maternity units in England and Wales. BMI at 12 months postpartum was the primary outcome. A range of clinical and behavioural secondary outcomes were examined. Interventions: Women attending maternity units randomised to intervention were invited to a weekly weight management group, which combined expertise from a commercial weight loss programme with clinical advice from midwives. Both intervention and control participants received usual care and leaflets on diet and physical activity in pregnancy. Results: Mean (SD) BMI at 12 months postpartum was 36.0 kg/m2 (5.2) in the control group, and 37.5 kg/m2 (6.7) in the intervention group. After adjustment for baseline BMI, the intervention effect was −0.02 (95% CI −0.04 to 0.01). The intervention group had an improved healthy eating score (3.08, 95% CI 0.16 to 6.00, p < 0.04), improved fibre score (3.22, 1.07 to 5.37, p < 0.01) and lower levels of risky drinking at 12 months postpartum compared to the control group (OR 0.45, 0.27 to 0.74, p < 0.002). The net incremental monetary benefit was not statistically significantly different between arms, although the probability of the intervention being cost-effective was above 60%, at policy-relevant thresholds. Conclusions: There was no significant difference between groups on the primary outcome of BMI at 12 months. Analyses of secondary outcomes indicated improved healthy eating and lower levels of risky drinking. Trial registration: Current Controlled Trials ISRCTN25260464
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