337 research outputs found
Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats
<p><b>Background and Purpose:</b> The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats.</p>
<p><b>Methods:</b> The left internal capsule was lesioned by a local injection of endothelin-1 (ET-1; 200 pmol) in adult spontaneously hypertensive rats. MgSO4 was administered (300 mg/kg SC) 30 minutes before injection of ET-1, plus 200 mg/kg every hour thereafter for 4 hours. Infarct size was measured by T2-weighted magnetic resonance imaging (day 2) and histology (day 11), and functional recovery was assessed on days 3 and 10 by the cylinder and walking-ladder tests.</p>
<p><b>Results:</b> ET-1 application induced a small, localized lesion within the internal capsule. Despite reducing blood pressure, MgSO4 did not significantly influence infarct volume (by magnetic resonance imaging: median, 2.1 mm3; interquartile range, 1.3 to 3.8, vs 1.6 mm3 and 1.2 to 2.1, for the vehicle-treated group; by histology: 0.3 mm3 and 0.2 to 0.9 vs 0.3 mm3 and 0.2 to 0.5, respectively). Significant forelimb and hindlimb motor deficits were evident in the vehicle-treated group as late as day 10. These impairments were significantly ameliorated by MgSO4 in both cylinder (left forelimb use, P<0.01 and both-forelimb use, P<0.03 vs vehicle) and walking-ladder (right hindlimb score, P<0.02 vs vehicle) tests.</p>
<p><b>Conclusions:</b> ET-1–induced internal capsule ischemia in spontaneously hypertensive rats represents a good model of lacunar infarct with small lesion size, minimal adverse effects, and a measurable motor deficit. Despite inducing mild hypotension, MgSO4 did not significantly influence infarct size but reduced motor deficits, supporting its potential utility for the treatment of lacunar infarct.</p>
Dwarf Galaxies in Clusters as Probes of Galaxy Formation and Dark Matter
We present the results of a Hubble Space Telescope (HST) ACS and WFPC2 study
of dwarf galaxies in the nearby Perseus Cluster, down to M_V = -12, spanning
the core and outer regions of this cluster. We examine how properties such as
the colour magnitude relation, structure and morphology are affected by
environment for the lowest mass galaxies. The low masses of dwarf galaxies
allow us to determine their environmentally driven based galaxy evolution, the
effects of which are harder to examine in massive galaxies. The structures of
our dwarfs in both the core and outer regions of the cluster are quantified
using the concentration, asymmetry and clumpiness (CAS) parameters. We find
that, on average, dwarfs in the outer regions of Perseus are more disturbed
than those in the cluster core, with higher asymmetries and clumpier light
distributions. We measure the (V-I)_0 colours of the dEs, and find that dwarfs
in both the inner and outer regions of the cluster lie on the same colour
magnitude relation. Based on these results, we infer that the disturbed dwarfs
in the cluster outskirts are likely "transition dwarfs", with their colours
transforming before their structures. Finally, we infer from the smoothness of
the cluster core population that dwarfs in the inner regions of the cluster
must be highly dark matter dominated to prevent their disruption by the cluster
potential. We derive a new method to determine the minimum mass the dwarfs must
have to prevent this disruption without the need for resolved spectroscopy, and
determine their mass-to-light ratios. At their orbit pericentre, dwarfs in the
core of Perseus require mass-to-light ratios between 1 and 120 to prevent their
disruption, comparable to those found for the Local Group dSphs.Comment: 6 pages, 5 figures. To appear in the proceedings of "A Universe of
dwarf galaxies" (Lyon, June 14-18 2010
Solar-Cycle Characteristics Examined in Separate Hemispheres: Phase, Gnevyshev Gap, and Length of Minimum
Research results from solar-dynamo models show the northern and southern
hemispheres may evolve separately throughout the solar cycle. The observed
phase lag between the hemispheres provides information regarding the strength
of hemispheric coupling. Using hemispheric sunspot-area and sunspot-number data
from Cycles 12 - 23, we determine how out of phase the separate hemispheres are
during the rising, maximum, and declining period of each solar cycle.
Hemispheric phase differences range from 0 - 11, 0 - 14, and 2 - 19 months for
the rising, maximum, and declining periods, respectively. The phases appear
randomly distributed between zero months (in phase) and half of the rise (or
decline) time of the solar cycle. An analysis of the Gnevyshev gap is conducted
to determine if the double-peak is caused by the averaging of two hemispheres
that are out of phase. We confirm previous findings that the Gnevyshev gap is a
phenomenon that occurs in the separate hemispheres and is not due to a
superposition of sunspot indices from hemispheres slightly out of phase. Cross
hemispheric coupling could be strongest at solar minimum, when there are large
quantities of magnetic flux at the Equator. We search for a correlation between
the hemispheric phase difference near the end of the solar cycle and the length
of solar-cycle minimum, but found none. Because magnetic flux diffusion across
the Equator is a mechanism by which the hemispheres couple, we measured the
magnetic flux crossing the Equator by examining magnetograms for Solar Cycles
21 - 23. We find, on average, a surplus of northern hemisphere magnetic flux
crossing during the mid-declining phase of each solar cycle. However, we find
no correlation between magnitude of magnetic flux crossing the Equator, length
of solar minima, and phase lag between the hemispheres.Comment: 15 pages, 7 figure
Automated Coronal Hole Detection using Local Intensity Thresholding Techniques
We identify coronal holes using a histogram-based intensity thresholding
technique and compare their properties to fast solar wind streams at three
different points in the heliosphere. The thresholding technique was tested on
EUV and X-ray images obtained using instruments onboard STEREO, SOHO and
Hinode. The full-disk images were transformed into Lambert equal-area
projection maps and partitioned into a series of overlapping sub-images from
which local histograms were extracted. The histograms were used to determine
the threshold for the low intensity regions, which were then classified as
coronal holes or filaments using magnetograms from the SOHO/MDI. For all three
instruments, the local thresholding algorithm was found to successfully
determine coronal hole boundaries in a consistent manner. Coronal hole
properties extracted using the segmentation algorithm were then compared with
in situ measurements of the solar wind at 1 AU from ACE and STEREO. Our results
indicate that flux tubes rooted in coronal holes expand super-radially within 1
AU and that larger (smaller) coronal holes result in longer (shorter) duration
high-speed solar wind streams
The Evolution of Sunspot Magnetic Fields Associated with a Solar Flare
Solar flares occur due to the sudden release of energy stored in
active-region magnetic fields. To date, the pre-cursors to flaring are still
not fully understood, although there is evidence that flaring is related to
changes in the topology or complexity of an active region's magnetic field.
Here, the evolution of the magnetic field in active region NOAA 10953 was
examined using Hinode/SOT-SP data, over a period of 12 hours leading up to and
after a GOES B1.0 flare. A number of magnetic-field properties and low-order
aspects of magnetic-field topology were extracted from two flux regions that
exhibited increased Ca II H emission during the flare. Pre-flare increases in
vertical field strength, vertical current density, and inclination angle of ~
8degrees towards the vertical were observed in flux elements surrounding the
primary sunspot. The vertical field strength and current density subsequently
decreased in the post-flare state, with the inclination becoming more
horizontal by ~7degrees. This behaviour of the field vector may provide a
physical basis for future flare forecasting efforts.Comment: Accepted for Publication in Solar Physics. 16 pages, 4 figure
Surface Turbulent Fluxes From the MOSAiC Campaign Predicted by Machine Learning
Reliable boundary-layer turbulence parametrizations for polar conditions are needed to reduce uncertainty in projections of Arctic sea ice melting rate and its potential global repercussions. Surface turbulent fluxes of sensible and latent heat are typically represented in weather/climate models using bulk formulae based on the Monin-Obukhov Similarity Theory, sometimes finely tuned to high stability conditions and the potential presence of sea ice. In this study, we test the performance of new, machine-learning (ML) flux parametrizations, using an advanced polar-specific bulk algorithm as a baseline. Neural networks, trained on observations from previous Arctic campaigns, are used to predict surface turbulent fluxes measured over sea ice as part of the recent MOSAiC expedition. The ML parametrizations outperform the bulk at the MOSAiC sites, with RMSE reductions of up to 70 percent. We provide a plug-in Fortran implementation of the neural networks for use in models
Multiresolution analysis of active region magnetic structure and its correlation with the Mt. Wilson classification and flaring activity
Two different multi-resolution analyses are used to decompose the structure
of active region magnetic flux into concentrations of different size scales.
Lines separating these opposite polarity regions of flux at each size scale are
found. These lines are used as a mask on a map of the magnetic field gradient
to sample the local gradient between opposite polarity regions of given scale
sizes. It is shown that the maximum, average and standard deviation of the
magnetic flux gradient for alpha, beta, beta-gamma and beta-gamma-delta active
regions increase in the order listed, and that the order is maintained over all
length-scales. This study demonstrates that, on average, the Mt. Wilson
classification encodes the notion of activity over all length-scales in the
active region, and not just those length-scales at which the strongest flux
gradients are found. Further, it is also shown that the average gradients in
the field, and the average length-scale at which they occur, also increase in
the same order. Finally, there are significant differences in the gradient
distribution, between flaring and non-flaring active regions, which are
maintained over all length-scales. It is also shown that the average gradient
content of active regions that have large flares (GOES class 'M' and above) is
larger than that for active regions containing flares of all flare sizes; this
difference is also maintained at all length-scales.Comment: Accepted for publication in Solar Physic
Reconstructing the 3-D Trajectories of CMEs in the Inner Heliosphere
A method for the full three-dimensional (3-D) reconstruction of the
trajectories of coronal mass ejections (CMEs) using Solar TErrestrial RElations
Observatory (STEREO) data is presented. Four CMEs that were simultaneously
observed by the inner and outer coronagraphs (COR1 and 2) of the Ahead and
Behind STEREO satellites were analysed. These observations were used to derive
CME trajectories in 3-D out to ~15Rsun. The reconstructions using COR1/2 data
support a radial propagation model. Assuming pseudo-radial propagation at large
distances from the Sun (15-240Rsun), the CME positions were extrapolated into
the Heliospheric Imager (HI) field-of-view. We estimated the CME velocities in
the different fields-of-view. It was found that CMEs slower than the solar wind
were accelerated, while CMEs faster than the solar wind were decelerated, with
both tending to the solar wind velocity.Comment: 17 pages, 10 figures, 1 appendi
Star cluster formation and star formation: the role of environment and star-formation efficiencies
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10509-009-0088-5By analyzing global starburst properties in various kinds of starburst and post-starburst galaxies and relating them to the properties of the star cluster populations they form, I explore the conditions for the formation of massive, compact, long-lived star clusters. The aim is to determine whether the relative amount of star formation that goes into star cluster formation as opposed to field star formation, and into the formation of massive long-lived clusters in particular, is universal or scales with star-formation rate, burst strength, star-formation efficiency, galaxy or gas mass, and whether or not there are special conditions or some threshold for the formation of star clusters that merit to be called globular clusters a few billion years later.Peer reviewe
Hall-conductivity sign change and fluctuations in amorphous NbGe films
The sign change in the Hall conductivity has been studied in thin amorphous
NbGe0.3) films. By changing the film thickness it is
shown that the field at which the sign reversal occurs shifts to lower values
(from above to below the mean-field transition field ) with increasing
film thickness. This effect can be understood in terms of a competition between
a positive normal and a negative fluctuation contribution to the Hall
conductivity.Comment: 5 pages, 4 figures, to appear in Phys. Rev.
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