A water vision for Johnstone

The Water Vision is based on ideas from The Netherlands which promote communication with the public on key water related issues in a local authority area. A Water Vision for Johnstone was developed in Renfrewshire, Scotland where serious flooding has occurred in the past and new, predominantly non-structural approaches to surface water management were demanded. The paper outlines the development of a ‘Water Vision for Johnstone’ which became a key outcome of the Interreg III B project ‘Urban Water’.The Water Toets (Assessments) are statutory procedures in the Netherlands which come into play from the concept stage of developments onwards to full implementation. They are undertaken jointly on behalf of the spatial planning authority and the water authorities to evaluate the impact of development on the water network. In contrast, the Water Vision is a less well-defined process to identify community needs and aspirations but in many areas the vision is essential to support the Water Toets. The Water Vision is initiated by planning officers from the municipalities asking very basic questions of their communities about what they required of the water network. It was felt that adopting such a proactive approach where virtually any question about water bodies and drainage infrastructure could be asked, would not be practicable in the UK and it was decided to assemble information about water issues in the area, the agencies involved and potential ways forward, before approaching the public.Johnstone was selected as a test area as it was felt that this locality included many of the water related problems that can be found throughout Renfrewshire. Key water issues were identified and a range of possible solutions provided. Problems, solutions and organisations responsible for different aspects of the water network are described in the document, using images and plans to facilitate the public awareness. Normally the man in the street would not be expected to be as familiar with the nature of water-related problems as the general public in the Netherlands. The Water Vision is yet to go to public consultation as it is currently primarily a planning tool in which council processes are embedded. However, it is planned that workshops including all key stakeholders involved in water management will be held. Those bodies currently responsible for water management will then be encouraged to discuss the various options and opportunities available in a creative and integrated manner. By working together as a team in addressing water related issues it will be possible to develop a vision for the future that better assists the public in moving forward together

A conventional surgical approach for removal of an ectopic tooth in the nasal cavity

A 40-year-old female patient presented to ears, nose and throat complaining of cacosmia and discharge from the left maxillary sinus. Her CT scan revealed an ectopic supplemental nasal tooth which could not be removed by nasoendoscopy. Therefore, a conventional intraoral surgical approach was taken. In this case, we discuss the indications for conventional surgical removal of teeth from the nasal cavity when a nasoendoscopic approach is not possible. We highlight the potential pitfalls of both conventional and nasoendoscopic approaches, including some essential considerations when treatment planning these cases

Dementias Platform UK (DPUK) Data Portal - supporting multi-modal data analysis, data linkage and real-world outcomes

DPUK relaunched the Data Portal in November 2017 to present openly available information on the data availability and technical capability of the Data Portal, which supports multi-modal research studies with various objectives from disease model validation to observation investigation. DPUK not only brings clinical data together from cohorts, but is now supporting multi-modal studies in genetics and imaging, as well as linkage opportunities to routine data using world-leading technical solutions to data sharing. The capacity, adaptability and sophistication of the UK Secure eResearch Platform which the Portal is housed on, allows for unprecedented levels of centralised access to rich cohort and routine data, which is consequentially leading to international collaboration and development ambition within epidemiology, bioinformatics, research methodology and technical research solutions. As of March 2018, DPUK is supporting 50 cohorts, 41 from the UK and 9 from across the rest of the world, alongside furthering links and access to routine data held in the UK and across the world. 20 research studies are underway, and the DPUK mission to enhance data science within dementia research is leading the conversation for developing a community of excellence in this field and across other research genres

Comprehensive composition of creosote using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS)

Creosote is a distillation product of coal tar and is widely used as wood preservative for railway sleepers, utility poles and for other applications. Creosote can have potentially negative effects on the environment and many of the components are toxic. This study presents the analysis of a Creosote sample from a former wood impregnation plant located in the UK. The sample was analysed using two dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS) and a database of compounds that could be detected was produced. The GCxGG-TOFMS was capable of detecting 1505 individual compounds, which is far more than previous estimates for the number of compounds present within Creosote. Post extraction derivatization using BTSFA with 1% TMCS was employed to increase the potential number of compounds detected with 255 derivatized compounds detected, 231 of which would not have been detected without prior derivatization. Selected derivatized compounds were quantified with limits of detection ranging from 0.6 mg/kg to 1.6 mg/kg from a concentrated dense non-aqueous phase liquid (DNAPL). This work presents the first published full analysis of a Creosote using GCxGC-TOFMS combined with derivatization

Urban built environment configuration and psychological distress in older men: Results from the Caerphilly study

Background Few studies have examined the impact of the built environment configuration upon mental health. The study examines the impact of objectively assessed land use and street network configuration upon psychological distress and whether this association is moderated by the natural environment and area-level deprivation. Methods In a community sample of 687 older men from the Caerphilly Prospective Study, built environment morphological metrics (morphometrics) were related to differences in psychological distress as measured by the General Health Questionnaire. Cross-sectional data were taken from the most recent (5th) phase. A multi-level analysis with individuals nested within census-defined neighbourhoods was conducted. Environmental measures comprised GIS-constructed land use and street network metrics, slope variability and a satellite derived measure of greenness. Results Reduced psychological distress was associated with residing in a terraced dwelling (OR = 0.48, p = 0.03), higher degrees of land-use mix (OR = 0.42, p = 0.03 for the high tertile) and having higher local-level street-network accessibility (‘movement potential’) (OR = 0.54, p = 0.03). Hillier topography with higher slope variability was associated with increased risks of psychological distress (OR = 1.38, p = 0.05). Conclusions The findings support our hypothesis that built environment configuration is independently associated with psychological distress. The study underscores the need for effective intervention in the planning and design of residential built environment to achieve the goal of health-sustaining communities

Comprehensive database of Manufactured Gas Plant tars – Part B Aliphatic and aromatic compounds

Rationale Coal tars are a mixture of organic and inorganic compounds and were produced as a by-product from the manufactured gas and coke making industries. The composition of the tar produced varied depending on many factors; these include the temperature of production and the type of retort used. As different production processes produce different tars, a comprehensive database of the compounds present within coal tars from different production processes is a valuable resource. Such a database would help to understand how their chemical properties differ and what hazards the compounds present within these tars might pose. This study focuses on the aliphatic and aromatic compounds present in a database of 16 different tars from 5 different production processes. Methods Samples of coal tar were extracted using accelerated solvent extraction (ASE) and derivatized post extraction using BSTFA with 1% TMCS. The derivatized samples were analysed using two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GCxGC/TOFMS). Results A total of 198 individual aliphatic and 951 individual aromatic compounds were detected within 16 tar samples produced by 5 different production processes. The PAH content of coal tars varies greatly depending on the production process used to obtain the tars and this is clearly demonstrated within the results. The aliphatic composition of the tars provided an important piece of analytical information that would have otherwise been missed with the detection of petrogenic compounds such as alkyl cyclohexanes. Conclusions The aromatic compositions of the tar samples varied greatly between the different production processes investigated and useful analytical information ws obtained about the individual production process groups. Alkyl cyclohexanes were detected in all samples from sites known to operate Carbureted Water Gas plants and not detected in those that did not. This suggests that petrogenic material may be expected at many UK gaswork sites

Comprehensive database of Manufactured Gas Plant tars – Part A Database

Rationale Coal tars are a mixture of organic and inorganic compounds and were by-products from the manufactured gas and coke making industries. Different manufacturing processes have resulted in the production of distinctly different tar compositions. This study presents a comprehensive database of compounds produced using two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GCxGC/TOFMS), analysing 16 tar samples produced by 5 distinct production processes. Methods Samples of coal tar were extracted using accelerated solvent extraction (ASE) and derivatized post extraction using N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) with 1% trimethylchlorosilane (TMCS). The derivatized samples were analysed using two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GCxGC/TOFMS). Results A total of 16 tar samples originating from 5 different production processes: Low Temperature Horizontal Retorts, Horizontal Retorts, Vertical Retorts, Carbureted Water Gas and Coke Ovens, were analysed. 2369 unique compounds were detected with 948 aromatic compounds, 196 aliphatic compounds, 380 sulphur-containing compounds, 209 oxygen-containing compounds, 262 nitrogen-containing compounds and 15 mixed heterocycles. Derivatization allowed the detection of 359 unique compounds, the majority in the form of hydroxylated polycyclic aromatic hydrocarbons, many of which would not have been detected without derivatization. Of the 2369 unique compounds detected 173 compounds were found to be present within all samples. Conclusions A unique comprehensive database of compounds detected within 16 tar samples from 5 different production processes was produced. The 173 compounds identified within every sample may be of particular importance from a regulatory standpoint. This initial study indicates that different production processes produce tars with different chemical signatures and it can be further expanded upon by in-depth analysis of the different compound types. The number of compounds presented within this database clearly demonstrates the analytical power of GCxGC/TOFMS

Dementias Platform UK (DPUK) Data Portal - World-leading infrastructure facilitating innovative multi-modal research

Introduction Modern team science requires effective sharing of data and skills. The DPUK Data Portal is a collection of tools, datasets and networks that allows for epidemiologists and specialist researchers alike to access, analyse and investigate cohort and different modalities of routine data across UK and international sources. Objectives and Approach The Portal is housed on an instance of UKSeRP (UK Secure eResearch Platform), that allows customisable infrastructure to be used for multi-modal research (thus far live in genetics, imaging and clinical data) for researchers across the world using remote access technology whilst allowing governance to remain with the data provider. A central team at Swansea University is responsible for data curation and processing, and runs an access procedure for researchers to apply to use data from multiple sources to be analysed in a central analysis environment. Other modalities are similarly hosted, with input from partner sites in Cardiff and Oxford. Results DPUK facilitates data access and research on 49 cohorts, 40 UK-based and 9 international. The centralised repository model including remote access and ability to store and make available different modalities of data, from phenotypic data, to genetic and imaging data, has allowed DPUK to begin to support research of varying topics, from those studying cognitive decline and Dementia as a disease, to those maturing analytical models. By providing access to data platforms specialising in genetics, imaging and routine clinical data, as well as to specialists in disease and biology to aid with its understanding, DPUK has realised a large-scale research exercise combining major data modalities on a central platform, and allow access to such rich data across the world under an umbrella of robust governance. Conclusion/Implications Globally, cohorts are pooling data, expertise and desire to enrich their own aims in partnership with a federated research community to enable in-depth scrutiny of the biological origins of dementia and the development and evaluation of novel approach to disease prevention and cure

Data Services for Cohort Studies: Increasing the impact of existing research studies and epidemiological readiness

Introduction The Dementias Platform UK (DPUK) Data Portal is a secure, accessible environment facilitating provision of rich data towards the largest Dementia, cognition and ageing community of cohort studies in the world. DPUK is also providing services for cohort studies and researchers to maximise the research potential of the programme’s community. Objectives and Approach As part of the engagement of DPUK cohorts with the Data Portal, cohorts will upload data onto the DPUK instance of UK Secure eResearch Platform infrastructure. The Data Portal allows access to a collaborative working space that allows cohorts to enrich their own data, perform their own analysis, and enhance the research potential of their data whilst making use of expertise at various DPUK sites, such as data linking, curation and multi-modal specialism. Cohort data divided into ontologies allows researchers to access data specific to their study needs and can be requested from multiple cohorts simultaneously. Results By utilising the Data Portal researchers have access to cohort data that has been prepared for dementia epidemiology using the agreed ontologies, providing more rapid access to cohort data that otherwise may be large and complex. The knowledge and experience of DPUK staff and collaborators can also help to guide nascent cohorts and feasibility studies into producing research-ready datasets, enabling them to achieve greater impact with their data. A range of analytical tools are provided on the Data Portal making analysis of a cohort’s own data or multiple independent datasets more accessible. Alongside data curation, DPUK also facilitates data linkage to routine sources, beginning with a Wales-wide use case that will expand to the UK over the course of the project. Conclusion/Implications Data from international sources accessible using a central platform permits international collaboration, with ontologies allowing previously disparate data to be combined and analysed to build knowledge and research impact. DPUK projects create policy leading results and operational research standards, enhancing cohort impact and discovery of benefits for Dementia patients