28 research outputs found

    The UK COVID-19 app: the failed co-production of a digital public service

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    The COVID-19 pandemic put governments under pressure to make radical and urgent decisions, and to implement new digital solutions to steer society and deliver public services. Our study analyzes social media discourse to understand the co-production of a digital public service in an emergency situation. Empirically, we mobilize Twitter netnography and discourse analysis to examine citizens’ perceptions of the contact tracing app (CTA) introduced by the UK government to tackle the pandemic and save lives. Our study contributes to research on public sector accountability for digital transformations by advancing scholarly understanding of how societal concerns and public perceptions impact the co-production of digital services. Our findings reveal a high level of public skepticism toward the app and a general distrust of the UK government among the main social challenges of the CTA's implementation. Furthermore, we evidence widespread public distress over the potential violation of democratic freedoms and misuse of the data collected by the app. Finally, we reflect on the linkages between the lack of governmental accountability and the difficulties in mitigating the expressed societal concerns, causing a corresponding resistance on the part of the public to engage in and support co-production

    Finding of the Low Molecular Weight Inhibitors of Resuscitation Promoting Factor Enzymatic and Resuscitation Activity

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    Background: Resuscitation promoting factors (RPF) are secreted proteins involved in reactivation of dormant actinobacteria, including Mycobacterium tuberculosis. They have been considered as prospective targets for the development of new antituberculosis drugs preventing reactivation of dormant tubercle bacilli, generally associated with latent tuberculosis. However, no inhibitors of Rpf activity have been reported so far. The goal of this study was to find low molecular weight compounds inhibiting the enzymatic and biological activities of Rpfs. Methodology/Principal Findings: Here we describe a novel class of 2-nitrophenylthiocyanates (NPT) compounds that inhibit muralytic activity of Rpfs with IC50 1–7 mg/ml. Fluorescence studies revealed interaction of active NPTs with the internal regions of the Rpf molecule. Candidate inhibitors of Rpf enzymatic activity showed a bacteriostatic effect on growth of Micrococcus luteus (in which Rpf is essential for growth protein) at concentrations close to IC50. The candidate compounds suppressed resuscitation of dormant (‘‘non-culturable’’) cells of M. smegmatis at 1 mg/ml or delayed resuscitation of dormant M. tuberculosis obtained in laboratory conditions at 10 mg/ml. However, they did not inhibit growth of active mycobacteria under these concentrations. Conclusions/Significance: NPT are the first example of low molecular weight compounds that inhibit the enzymatic an

    Microsatellite-based genetic diversity and population structure of domestic sheep in northern Eurasia

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    <p>Abstract</p> <p>Background</p> <p>Identification of global livestock diversity hotspots and their importance in diversity maintenance is essential for making global conservation efforts. We screened 52 sheep breeds from the Eurasian subcontinent with 20 microsatellite markers. By estimating and weighting differently within- and between-breed genetic variation our aims were to identify genetic diversity hotspots and prioritize the importance of each breed for conservation, respectively. In addition we estimated how important within-species diversity hotspots are in livestock conservation.</p> <p>Results</p> <p>Bayesian clustering analysis revealed three genetic clusters, termed Nordic, Composite and Fat-tailed. Southern breeds from close to the region of sheep domestication were more variable, but less genetically differentiated compared with more northern populations. Decreasing weight for within-breed diversity component led to very high representation of genetic clusters or regions containing more diverged breeds, but did not increase phenotypic diversity among the high ranked breeds. Sampling populations throughout 14 regional groups was suggested for maximized total genetic diversity.</p> <p>Conclusions</p> <p>During initial steps of establishing a livestock conservation program populations from the diversity hot-spot area are the most important ones, but for the full design our results suggested that approximately equal population presentation across environments should be considered. Even in this case, higher per population emphasis in areas of high diversity is appropriate. The analysis was based on neutral data, but we have no reason to think the general trend is limited to this type of data. However, a comprehensive valuation of populations should balance production systems, phenotypic traits and available genetic information, and include consideration of probability of success.</p

    The accountability of advocacy NGOs: insights from the online community of practice

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    Advocacy non-governmental organisations (NGOs) play an important role in society by keeping in check the power of corporations and governments and uncovering rights violations. They differ from other NGOs in terms of their agenda, funding structure and the stakeholders they serve, and operate in a context characterised by increasing demands for transparency, accountability and responsible advocacy. This study examines how the accountability agenda of advocacy NGOs is shaped by the need to maintain independence, preserve values and keep reputation unsullied when faced with financial and legitimacy pressures. A netnography method is employed to analyse the discussions taking place in the NGOs’ online community of practice to understand the implications of the accountability challenges faced by advocacy NGOs through the perceptions of NGO professionals. The study reveals that the accountability agenda of advocacy NGOs is determined by the interrelated threats of financial vulnerability, potential loss of independence, legitimacy challenges and the high level of public scrutiny. The findings highlight that imperfect accountability mechanisms (e.g. financial reporting and performance management systems) hinder the ability of advocacy NGOs to demonstrate their accountability

    Fund accounting : theoretical and empirical study

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    The public sector operates in the context of increasing demand for transparency and accountability and better control of financial resources spending. Governmental organizations differ from business enterprises in their missions, ways of revenue acquisition and performance evaluation. At the same time, international discussion about how to develop and improve governmental accounting uses commercial accounting as the only accounting framework and do not provide an attention to other available accounting models, such as fund accounting and cameral accounting. The thesis aims to introduce fund accounting into this international debate. The study acquires knowledge about fund accounting as an accounting platform, which is used when carrying out an empirical study, analyzing the financial statements of the City of Wolverhampton, UK. The study discusses if fund accounting, or some of its elements, could be of interest to use as a part of the accounting framework in the public sector. The study finds that even though, municipal accounting uses some elements based on the original fund approach, the fundamental fund accounting concepts changed their meanings affected by the current accounting trends of business accounting standards adoption in the public sector. The study takes into consideration the advantages of fund accounting, such as focus on budgetary control and fiduciary stewardship and suggests its improvement and simplification in order to serve the public sector better, but not the replacement by the commercial (accrual) accounting
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