Genomics-assisted breeding in four major pulse crops of developing countries: present status and prospects

The global population is continuously increasing and is expected to reach nine billion by 2050. This huge population pressure will lead to severe shortage of food, natural resources and arable land. Such an alarming situation is most likely to arise in developing countries due to increase in the proportion of people suffering from protein and micronutrient malnutrition. Pulses being a primary and affordable source of proteins and minerals play a key role in alleviating the protein calorie malnutrition, micronutrient deficiencies and other undernourishment-related issues. Additionally, pulses are a vital source of livelihood generation for millions of resource-poor farmers practising agriculture in the semi-arid and sub-tropical regions. Limited success achieved through conventional breeding so far in most of the pulse crops will not be enough to feed the ever increasing population. In this context, genomics-assisted breeding (GAB) holds promise in enhancing the genetic gains. Though pulses have long been considered as orphan crops, recent advances in the area of pulse genomics are noteworthy, e.g. discovery of genome-wide genetic markers, high-throughput genotyping and sequencing platforms, high-density genetic linkage/QTL maps and, more importantly, the availability of whole-genome sequence. With genome sequence in hand, there is a great scope to apply genome-wide methods for trait mapping using association studies and to choose desirable genotypes via genomic selection. It is anticipated that GAB will speed up the progress of genetic improvement of pulses, leading to the rapid development of cultivars with higher yield, enhanced stress tolerance and wider adaptability

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Diseño Técnico Pedagógico manejo y aprovechamiento de bosques

Programa modular de formación profesional sector agropecuario para la especialidad manejo y aprovechamiento de bosques aplicable al año de 1990 en el que se presenta el itinerario de formación, bloques modulares, módulos instruccionales e intensidad horaria.Modular program of vocational training in the agricultural sector for the specialty management and use of forests applicable to the year 1990 in which the training itinerary, modular blocks, instructional modules and hourly intensity are presented.Resumen del estudio integral del trabajo -- Resultados obtenidos -- Guia de manejo del programa modular -- Diseño técnico pedagógico de recursos forestales -- Viveros Forestales Plantaciones Forestales -- Sistemas agroforestales -- Medición Forestal -- Aprovechamiento del bosque -- Mantenimiento y/o reparación de motosierras -- Transporte Forestal -- Establecimiento y montaje del aserradero -- Procesos de preservación de la maderana147 página

Crítica y Emancipación. Revista Latinoamericana de Ciencias Sociales (Año V no. 9 primer semestre 2013)

Sumario: Asamblea General: Conferencia Latinoamericana y Caribeña. El estado de las ciencias sociales en América Latina y el Caribe. Consejo Latinoamericano de Ciencias Sociales (CLACSO)-MOST/UNESCO México DF, 6 al 9 de noviembre de 2012- Emir Sader Capitalismo corporativo y ciencias sociales - Pablo González Casanova La cuestión étnica: identidades, derechos y luchas - Rodolfo Stavenhagen Mujeres, pintura y política - Elena Poniatowska Los derechos de los trabajadores - Eduardo Galeano El horizonte ampliado de la interculturalidad - Néstor García Canclini Diálogos latinoamericanos: Entrevista a Fernando Martínez Heredia - Emir Sader Memoria: Francisco Fernández Buey: poliética, filosofía, economía, ciencia con conciencia... 4 de junio de 1943, Palencia 25 de agosto de 2012, Barcelona - Jordi Mir Garcia Hasta siempre a un pacifista Guillermo Hoyos Vázquez 1 de septiembre de 1935, Medellín 5 de enero de 2013, Bogotá - Guillermo Almeyra Chávez: la crítica y la emancipación Perspectivas: El Estado-nación visto por los sin papeles - Emmanuel Terray A proteção ao trabalho entre a realidade das crises econômicas e a normatividade da constituição - Enzo Bello Revistas de Nuestra América: Revista Brasiliense - Luiz Bernardo Pericás Lecturas Críticas: Culturas políticas, ideas e intelectuales en tensión A propósito de Peronismo y cultura de izquierda, de Carlos Altamirano - Hernán Camarero

Uso de mallas moleculares en la descontaminación de desechos líquidos

IP 1115-13-236-94v.1. Informe Final / Carlos Saldarriaga Molina ... [et al.] --v.2. Remocion de cromo de la industria de curtiembres utilizando mallas moleculares / Edison Gil Pavas --v.3. Remocion de cromo (III) de aguas residuales de curtiembres / Monica Maria Moreno Casafus, ClaudiaPatriciaRamirez Ochoa y Claudia Yanet Tamayo Martinez -- v.4. Eliminacion de Cr3+ con zeolitas naturales colombianas /Auddy Alvarez Sanchez, Jhon Kirk Walter Villareal y Jorge Hernan Chica Betancur -- v.5. Remociondel cromo3+ de aguas residuales de curtiembres utilizando modernita / Beatriz Elena Caro y CesarAugusto Quintero -- v.6. Tratamiento de aguas residuales de curtiembres con bentonita activada / Ligia IbarraPulgarin yNorman A. Lopez Ramirez -- v.7. Recuperacion de cromo de aguas residuales de curtiembres por medio de mallas moleculares tipo alpo4-5 sustituida con cobalto / Luis Fernando Duque Osorio, MauricioAlexander Carmona Gomez y Carlos Mario Aristizabal Cardona -- v.8. Fabricacion de pastillas de mallasmolecularesutilizando como aglutinantes caolin y lignosulfonato de sodio / Farith Adilson Diaz Arriaga, BorisRonald Medina y Arley David Zapata Zapata -- v.9. Remocion de cromo (III) de aguas residuales de curtiembrespor intercambio ionico / Ana Maria Calderin Lopez, Juan Fernando Hernandez Ospina y Juan Miguel MarinSepulveda -- v.10. Sintesis de la ettringita y su aplicacion en la remocion de cromo de aguas de curtiembres/ Miguel Octavio Jaramillo G. y Bernardo A. Galeano

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele