Anales de Edafología y Agrobiología Tomo 32 Número 9-10

Aportaciones para un mejor conocimiento de los suelos desarrollados sobre materiales calizos consolidados, por J. L. Moreno Alvarez y T. Badorrey Peracho.-- Estudio biológico y químico de Erica umbellata L., por M. Consolación Salas, Antonio Ballester y Ernesto Vieitez.--Contenido en metales de la nitrito reductasa del alga Chlorella, por J. Cárdenas, F. D. Pineda, F. F. de la Rosa, J. L. Barea y J. Rivas.-- Andosuelos de la provincia de Gerona. I. Estudio de sustancias minerales amorfas, por J. Rodríguez Sanchidrián y F Monturiol Rodríguez.-- Minerales de la arcilla en suelos de la provincia de Granada, por J. L. Martín Vivaldi, E. Galán Huertos y F. López Aguayo.-- Influence of foliar application of macro-nutrient on the plant growth and rnultiplication of viruses. I. Foliar application of nitrogen nutrient to tomato and its effect on host growth and potato virus X multiplication, by Rajendra Singh and Tej Pratap Mall.-- Heterodera Schachtii Schmidt, 1871 (Nematoda: Heteroderidae) en los suelos de las Islas Canarias, por A. Bello y Mª. D. Romero.-- Utiliización de una nueva fórmula de cálculo para la evaporación de Piché en regiones húmedas de España, por Jesús Seco, Angela Calvo y José Garmendía.-- Contribución al estudio de la técnica de Walkley y Black para la determinación de carbono orgánico de suelos, por Luisa Prat Pérez y Benito Sánchez.-- Estudio de la dinámica del crecimiento del limón en el sureste español, por O. Carpena, F. Romojaro, C. Alearaz y S. Llorente.-- Efecto de la aplicación de acetileno y ácido 2-cloroetilfosfónico sobre la fructificación y cosecha del olivo, por A. J. Sánchez-Raya, J. P. Donaire y L. Recalde.—Notas científicas.-- Estudio de fosfatasa ácida en plantas de A tropa belladona L. recogidas en otoño, por M. R. Felipe Antón y N. Velázquez Sánchez.—Notas.-- Nombramiento de Presidente del C. S. I. C.-- Constitución de la nueva Junta de Gobierno del Patronato Alonso de Herrera.-- Nombramiento de Consejeros de Número.-- Nombramiento de Consejeros Adjuntos.-- Designación del Comité Nacional de la Unión Internacional de Investigaciones sobre el Cuaternario.-- Rector de la Universidad de La Laguna.-- Distinción al Pro f. Zorita.-- European Grassland Federation (5th General Meeting).-- Reuniones nacionales.-- 1ª Reunión Nacional del Grupo de Trabajo del Cuaternario.-- Laboratorio de Micromorfología de Suelos.-- Próximo Congreso de Micromorfología.-- Reunión en La Mayora.-- BibliografíaPeer reviewed2019-08.- CopyBook.- Libnova.- Biblioteca ICA

Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease

Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10- (95% CI 3.3 × 10--1.1 × 10-)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD

Association of candidate gene polymorphisms with chronic kidney disease : Results of a case-control analysis in the NEFRONA cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2,445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionization-time of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD