503 research outputs found
Exploring the interplay between Buddhism and career development : a study of highly skilled women workers in Sri Lanka
This article adopts a socio cultural lens to examine the role of Buddhism in highly skilled women workers’ careers in Sri Lanka. While Buddhism enabled women’s career development by giving them strength to cope with difficult situations in work, it also seemed to restrict their agency and constrain their career advancement. Based on our findings, we argue that being perceived as a good Buddhist woman worked as a powerful form of career capital for the respondents in our sample, who used their faith to combat gender disadvantage in their work settings
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels
Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and the phosphodiesterases which degrade these compounds. In this paper, we employ a systems biology approach to develop mathematical models of these networks that, for the first time, take into account the different biochemical properties of the isoforms involved. To investigate the mechanisms underlying the joint regulation of cAMP and cGMP, we apply our models to analyse the regulation of cilia beat frequency in Paramecium by Ca(2+). Based on our analysis of these models, we propose that the diversity of isoform combinations that occurs in living cells provides an explanation for the huge variety of intracellular processes that are dependent on these networks. The inclusion of both G-protein receptor and Ca(2+)-dependent regulation of AC in our models allows us to propose a new explanation for the switching properties of G-protein subunits involved in nucleotide regulation. Analysis of the models suggests that, depending on whether the G-protein subunit is bound to AC, Ca(2+) can either activate or inhibit AC in a concentration-dependent manner. The resulting analysis provides an explanation for previous experimental results that showed that alterations in Ca(2+) concentrations can either increase or decrease cilia beat frequency over particular Ca(2+) concentration ranges
Superweakly interacting dark matter from the Minimal Walking Technicolor
We study a superweakly interacting dark matter particle motivated by minimal
walking technicolor theories. Our WIMP is a mixture of a sterile state and a
state with the charges of a standard model fourth family neutrino. We show that
the model can give the right amount of dark matter over a range of the WIMP
mass and mixing angle. We compute bounds on the model parameters from the
current accelerator data including the oblique corrections to the precision
electroweak parameters, as well as from cryogenic experiments, Super-Kamiokande
and from the IceCube experiment. We show that consistent dark matter solutions
exist which satisfy all current constraints. However, almost the entire
parameter range of the model lies within the the combined reach of the next
generation experiments.Comment: 29 pages, 6 figure
Search for Supersymmetric Dark Matter with Superfluid He3 (MACHe3)
MACHe3 (MAtrix of Cells of superfluid He3) is a project of a new detector for
direct Dark Matter search, using superfluid He3 as a sensitive medium. This
paper presents a phenomenological study done with the DarkSUSY code, in order
to investigate the discovery potential of this project of detector, as well as
its complementarity with existing and planned devices.Comment: 15 pages, 5 figures, submitted to Phys. Letters B, minor changes in
the tex
Charge amplification concepts for direction-sensitive dark matter detectors
Direction measurement of weakly interacting massive particles in
time-projection chambers can provide definite evidence of their existence and
help to determine their properties. This article demonstrates several concepts
for charge amplification in time-projection chambers that can be used in
direction-sensitive dark matter search experiments. We demonstrate
reconstruction of the 'head-tail' effect for nuclear recoils above 100keV, and
discuss the detector performance in the context of dark matter detection and
scaling to large detector volumes.Comment: 15 pages, 9 figure
First Results from the DRIFT-IIa Dark Matter Detector
Data from the DRIFT-IIa directional dark matter experiment are presented,
collected during a near continuous 6 month running period. A detailed
calibration analysis comparing data from gamma-ray, x-ray and neutron sources
to a GEANT4 Monte Carlo simulations reveals an efficiency for detection of
neutron induced recoils of 94+/-2(stat.)+/-5(sys.)%. Software-based cuts,
designed to remove non-nuclear recoil events, are shown to reject 60Co
gamma-rays with a rejection factor of better than 8x10-6 for all energies above
threshold. An unexpected event population has been discovered and is shown here
to be due to the alpha-decay of 222Rn daughter nuclei that have attached to the
central cathode. A limit on the flux of neutrons in the Boulby Underground
Laboratory is derived from analysis of unshielded and shielded data.Comment: 43 pages, 14 figures, submitted to Astroparticle Physic
Constraints on inelastic dark matter from XENON10
It has been suggested that dark matter particles which scatter inelastically
from detector target nuclei could explain the apparent incompatibility of the
DAMA modulation signal (interpreted as evidence for particle dark matter) with
the null results from CDMS-II and XENON10. Among the predictions of
inelastically interacting dark matter are a suppression of low-energy events,
and a population of nuclear recoil events at higher nuclear recoil equivalent
energies. This is in stark contrast to the well-known expectation of a falling
exponential spectrum for the case of elastic interactions. We present a new
analysis of XENON10 dark matter search data extending to E keV
nuclear recoil equivalent energy. Our results exclude a significant region of
previously allowed parameter space in the model of inelastically interacting
dark matter. In particular, it is found that dark matter particle masses
GeV are disfavored.Comment: 8 pages, 4 figure
CDMS, Supersymmetry and Extra Dimensions
The CDMS experiment aims to directly detect massive, cold dark matter
particles originating from the Milky Way halo. Charge and lattice excitations
are detected after a particle scatters in a Ge or Si crystal kept at ~30 mK,
allowing to separate nuclear recoils from the dominating electromagnetic
background. The operation of 12 detectors in the Soudan mine for 75 live days
in 2004 delivered no evidence for a signal, yielding stringent limits on dark
matter candidates from supersymmetry and universal extra dimensions. Thirty Ge
and Si detectors are presently installed in the Soudan cryostat, and operating
at base temperature. The run scheduled to start in 2006 is expected to yield a
one order of magnitude increase in dark matter sensitivity.Comment: To be published in the proceedings of the 7th UCLA symposium on
sources and detection of dark matter and dark energy in the universe, Marina
del Rey, Feb 22-24, 200
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