The Perceived Effectiveness of Women’s Pick-Up Lines: Do Age and Personality Matter?

One way to initiate a conversation for the purposes of mate attraction is to use a pickup line. While past research has addressed men’s use of pick-up lines, there has been far less research on those used by women. Here, we explored the perceived effectiveness of women’s pick-up lines, particularly with regard to one’s age but also as correlated with their Big Five personality factors. We hypothesized that both men and women would rate the same pick-up lines as effective and that older participants would rate pick-up lines as more effective than younger participants. Our results indicate that women’s use of direct pick-up lines, sharing things in common, asking for a phone number, indirectly hinting at a date, and asking if single were perceived as most effective by both sexes. We did not support our prediction about age. The results demonstrate that of the Big Five dimensions, extraversion in particular is important and was positively correlated with perceived effectiveness

Strategic analysis for the MER Cape Verde approach

The Mars Exploration Rover Opportunity has recently completed a two year campaign studying Victoria Crater. The campaign culminated in a close approach of Cape Verde in order to acquire high resolution imagery of the exposed stratigraphy in the cliff face. The close approach to Cape Verde provided significant challenges for every subsystem of the rover as the rover needed to traverse difficult, un-characterised terrain and approach a cliff face with the potential of blocking out solar energy and communications with Earth. In this paper we describe the strategic analyses performed by the science and engineering teams so that we could successfully achieve the science objectives while keeping the rover safe

Low-bandwidth authentication.

Remotely-fielded unattended sensor networks generally must operate at very low power--in the milliwatt or microwatt range--and thus have extremely limited communications bandwidth. Such sensors might be asleep most of the time to conserve power, waking only occasionally to transmit a few bits. RFID tags for tracking or material control have similarly tight bandwidth constraints, and emerging nanotechnology devices will be even more limited. Since transmitted data is subject to spoofing, and since sensors might be located in uncontrolled environments vulnerable to physical tampering, the high-consequence data generated by such systems must be protected by cryptographically sound authentication mechanisms; but such mechanisms are often lacking in current sensor networks. One reason for this undesirable situation is that standard authentication methods become impractical or impossible when bandwidth is severely constrained; if messages are small, a standard digital signature or HMAC will be many times larger than the message itself, yet it might be possible to spare only a few extra bits per message for security. Furthermore, the authentication tags themselves are only one part of cryptographic overhead, as key management functions (distributing, changing, and revoking keys) consume still more bandwidth. To address this problem, we have developed algorithms that provide secure authentication while adding very little communication overhead. Such techniques will make it possible to add strong cryptographic guarantees of data integrity to a much wider range of systems

Novel <i>IRF6 </i>mutations in families with Van Der Woude syndrome and popliteal pterygium syndrome from sub-Saharan Africa

Orofacial clefts (OFC) are complex genetic traits that are often classified as syndromic or nonsyndromic clefts. Currently, there are over 500 types of syndromic clefts in the Online Mendelian Inheritance in Man (OMIM) database, of which Van der Woude syndrome (VWS) is one of the most common (accounting for 2% of all OFC). Popliteal pterygium syndrome (PPS) is considered to be a more severe form of VWS. Mutations in the IRF6 gene have been reported worldwide to cause VWS and PPS. Here, we report studies of families with VWS and PPS in sub-Saharan Africa. We screened the DNA of eight families with VWS and one family with PPS from Nigeria and Ethiopia by Sanger sequencing of the most commonly affected exons in IRF6 (exons 3, 4, 7, and 9). For the VWS families, we found a novel nonsense variant in exon 4 (p.Lys66X), a novel splice-site variant in exon 4 (p.Pro126Pro), a novel missense variant in exon 4 (p.Phe230Leu), a previously reported splice-site variant in exon 7 that changes the acceptor splice site, and a known missense variant in exon 7 (p.Leu251Pro). A previously known missense variant was found in exon 4 (p.Arg84His) in the PPS family. All the mutations segregate in the families. Our data confirm the presence of IRF6-related VWS and PPS in sub-Saharan Africa and highlights the importance of screening for novel mutations in known genes when studying diverse global populations. This is important for counseling and prenatal diagnosis for high-risk families

Impact of the 2014–2016 marine heatwave on US and Canada West Coast fisheries: Surprises and lessons from key case studies

Marine heatwaves are increasingly affecting marine ecosystems, with cascading impacts on coastal economies, communities, and food systems. Studies of heatwaves provide crucial insights into potential ecosystem shifts under future climate change and put fisheries social-ecological systems through “stress tests” that expose both vulnerabilities and resilience. The 2014–16 Northeast Pacific heatwave was the strongest and longest marine heatwave on record and resulted in profound ecological changes that impacted fisheries, fisheries management, and human livelihoods. Here, we synthesize the impacts of the 2014–2016 marine heatwave on US and Canada West Coast fisheries and extract key lessons for preparing global fisheries science, management, and industries for the future. We set the stage with a brief review of the impacts of the heatwave on marine ecosystems and the first systematic analysis of the economic impacts of these changes on commercial and recreational fisheries. We then examine ten key case studies that provide instructive examples of the complex and surprising challenges that heatwaves pose to fisheries social-ecological systems. These reveal important insights into improving the resilience of monitoring and management and increasing adaptive capacity to future stressors. Key recommendations include: (1) expanding monitoring to enhance mechanistic understanding, provide early warning signals, and improve predictions of impacts; (2) increasing the flexibility, adaptiveness, and inclusiveness of management where possible; (3) using simulation testing to help guide management decisions; and (4) enhancing the adaptive capacity of fishing communities by promoting engagement, flexibility, experimentation, and failsafes. These advancements are important as global fisheries prepare for a changing oceanWe are grateful to Nate Mantua, Manuel Hidalgo, Kiva Oken, and Cori Lopazanski for feedback on manuscript drafts. We thank Jean Lee for sharing a non-confidential version of the Gulf of Alaska commercial fisheries landings data and Evan Damkjar and John Davidson for sharing non-confidential versions of British Columbia's commercial and recreational fisheries landings data. CMF was funded by The Nature Conservancy, California. BM was partially supported by the Future Seas II project under NOAA's Climate and Fisheries Adaptation Program (NA20OAR431050). The scientific results and conclusions, as well as any views or opinions expressed herein, are those of the author(s) and do not necessarily reflect the views of NOAA or the Department of Commerce.Ye

Optimising experimental design for high-throughput phenotyping in mice: a case study

To further the functional annotation of the mammalian genome, the Sanger Mouse Genetics Programme aims to generate and characterise knockout mice in a high-throughput manner. Annually, approximately 200 lines of knockout mice will be characterised using a standardised battery of phenotyping tests covering key disease indications ranging from obesity to sensory acuity. From these findings secondary centres will select putative mutants of interest for more in-depth, confirmatory experiments. Optimising experimental design and data analysis is essential to maximise output using the resources with greatest efficiency, thereby attaining our biological objective of understanding the role of genes in normal development and disease. This study uses the example of the noninvasive blood pressure test to demonstrate how statistical investigation is important for generating meaningful, reliable results and assessing the design for the defined research objectives. The analysis adjusts for the multiple-testing problem by applying the false discovery rate, which controls the number of false calls within those highlighted as significant. A variance analysis finds that the variation between mice dominates this assay. These variance measures were used to examine the interplay between days, readings, and number of mice on power, the ability to detect change. If an experiment is underpowered, we cannot conclude whether failure to detect a biological difference arises from low power or lack of a distinct phenotype, hence the mice are subjected to testing without gain. Consequently, in confirmatory studies, a power analysis along with the 3Rs can provide justification to increase the number of mice used

Balance Rehabilitation in Multiple Sclerosis: A Comparison of Conventional Training with Nintendo® Wii Fit Game Play

Balance and gait disturbances are commonly observed, but poorly managed, in individuals with multiple sclerosis (MS). This pilot study compared the effects of Nintendo® Wii FitTM game play (WII), conventional balance training (TRAD), and control (CON) on balance and mobility outcomes among home-dwelling persons with MS. Nineteen female and 6 male MS patients (mean age: 45.3±8.8 years) with self-reported balance deficits underwent clinical assessment using the Berg Balance Scale (BBS) before (0 weeks, PRE) and after 3 weeks of supervised balance training sessions (MID) and again after 9 weeks of at-home training (POST). Participants further completed questionnaires regarding balance confidence (ABC), walking ability (MSWS-12) and fatigue (MFIS). All training was 3 sessions per week for 30 minutes per session. Compliance varied substantially between individuals for at-home training, but was 100% for supervised training. Effect sizes from PRE to MID and PRE to POST testing were calculated for each group and outcome measure to demonstrate magnitude of change. Following supervised training, both training protocols had greater effects on BBS scores than CON (d’=-0.43), with TRAD (d’=0.84) having a larger effect than WII (d’=0.60). These effects remained following at-home training. PRE to POST effect sizes for BBS scores were as follows: CON, d’= 0.08; TRAD, d’=1.08; WII, d’= 0.75. Questionnaires showed similar trends with effect sizes from PRE to POST for ABC (d’=0.15, 1.02 and 0.34), MSWS-12 (d’=-0.34, 0.35 and 0.27) and MFIS (d’=-0.92, 0.45 and -0.04) for CON, TRAD and WII, respectively. Results suggest that balance rehabilitation training using WII and TRAD may both be effective in improving balance, confidence, perceived walking ability, and fatigue when compared to CON, with TRAD being potentially more effective than WII for this subset of individuals with MS

Provider perspectives and reach of an evidence-based intervention in community services for toddlers.

Lay abstractExpert recommendations for toddlers who are likely to develop autism include caregivers being actively involved in the services children receive. However, many services available in the community may not follow these recommendations. Evidence suggests that an intervention named Project ImPACT for Toddlers demonstrates positive parent and child outcomes for families in the community. Project ImPACT for Toddlers was designed specifically for toddlers by a group of parents, clinicians, researchers, and funders. It teaches parents of young children strategies to support their child's development in daily routines. This study reports the perspectives of early intervention providers who learned to use Project ImPACT for Toddlers on whether the intervention was a good fit for their practice and easy to use. The study also examines how many agencies are using Project ImPACT for Toddlers and how many families have received the intervention in the community. The goal of the study is to inform the continued use of Project ImPACT for Toddlers in the community and support offering the intervention in other regions. Participants include 38 community providers who participated in a training study of Project ImPACT for Toddlers and completed a survey and semi-structured interview after approximately 3 months of using Project ImPACT for Toddlers with families. Participants perceived the training model as acceptable and appropriate, and identified the group-based model of training, comprehensive materials, and agency support as strengths of the approach. Survey findings complemented the results from the interviews. Data indicate an increasing number of agencies and families accessing Project ImPACT for Toddlers. Efforts to expand evidence-based intervention in early intervention should continue to build upon the model used for Project ImPACT for Toddlers

Species relationships and phenotypes of the study species.

(A) The African clawed frog Xenopus laevis (Pipidae) is a model organism for laboratory studies and for developing in vivo techniques for testing gene function. Images by JD, the adult was photographed near Hluhluwe, KwaZulu-Natal, South Africa. (B) The glassfrog Hyalinobatrachium fleischmanni (Centrolenidae) exhibits transparent tissues, through which many organs are visible during embryonic, tadpole and adult life-stages. Fathers provide parental care to developing eggs and embryos can time hatching in response to parenting [28–31]. Images by JD, the adult was photographed near San Gabriel Mixtepec, Oaxaca, Mexico. (C) Allobates femoralis is a cryptic poison frog (Aromobatidae) whose adult behavior is well studied in the context of spatial cognition and parental behavior [32–35]. Images by DS (tadpole) and Andrius Pašukonis (adult from Nouragues Nature Reserve, French Guiana). (D) Poison frogs of the Dendrobatidae are well known for their aposematic coloration, chemical defenses, and diverse social behaviors [25–27, 36]. Images are of Dendrobates tinctorius by DS (captive animals) and Ranitomeya imitator, by DS (tadpole) and Evan Twomey (adult from near San Jose, San Martin, Peru).</p