7,124 research outputs found
Cardiovascular Health in Pregnant Women and Their Children - The Generation R Study
__Abstract__
Cardiovascular disease is a major public health problem in the general adult population.
1 Cardiovascular disease leads to over 17.3 million deaths per year and is the leading
cause of death and disability worldwide.1 In the Netherlands, cardiovascular disease
accounts for approximately 30% of current mortality rates among men and women.2
Because of the clinical impact that cardiovascular and metabolic diseases have at older
ages, research into related risk factors has mostly been focused on adults. However, in
the last decades, an accumulating body of evidence suggested that cardiovascular
health in younger age groups also has major long-term public health implications
Maternal obesity during pregnancy and cardiovascular development and disease in the offspring
Maternal obesity during pregnancy is an important public health problem in Western countries. Currently, obesity prevalence rates in pregnant women are estimated to be as high as 30 %. In addition, approximately 40 % of women gain an excessive amount of weight during pregnancy in Western countries. An accumulating body of evidence suggests a long-term impact of maternal obesity and excessive weight gain during pregnancy on adiposity, cardiovascular and metabolic related health outcomes in the offspring in fetal life, childhood and adulthood. In this review, we discuss results from recent studies, potential underlying mechanisms and challenges for future epidemiological studies
Comment on ``Inflation and flat directions in modular invariant superstring effective theories''
The inflation model of Gaillard, Lyth and Murayama is revisited, with a
systematic scan of the parameter space for dilaton stabilization during
inflation.Comment: 7 pages, 2 figure
Therapeutic Vascular Compliance Change May Cause Significant Variation in Coronary Perfusion: A Numerical Study
In some pathological conditions like aortic stiffening and calcific aortic stenosis (CAS), the microstructure of the aortic root and the aortic valve leaflets are altered in response to stress resulting in changes in tissue thickness, stiffness, or both. This aortic stiffening and CAS are thought to affect coronary blood flow. The goal of the present paper was to include the flow in the coronary ostia in the previous fluid structure interaction model we have developed and to analyze the effect of diseased tissues (aortic root stiffening and CAS) on coronary perfusion. Results revealed a significant impact on the coronary perfusion due to a moderate increase in the aortic wall stiffness and CAS (increase of the aortic valve leaflets thickness). A marked drop of coronary peak velocity occurred when the values of leaflet thickness and aortic wall stiffness were above a certain threshold, corresponding to a threefold of their normal value. Consequently, mild and prophylactic treatments such as smoking cessation, exercise, or diet, which have been proven to increase the aortic compliance, may significantly improve the coronary perfusion
Three-way electrical gating characteristics of metallic Y-junction carbon nanotubes
Y-junction based carbon nanotube (CNT) transistors exhibit interesting switching behaviors, and have the structural advantage that the electrical gate for current modulation can be formed by any of the three constituent branches. In this letter, we report on the gating characteristics of metallic Y-CNT morphologies. By measuring the output conductance and transconductance we conclude that the efficiency and gain depend on the branch diameter and is electric field controlled. Based on these principles, we propose a design for a Y-junction based CNT switching device, with tunable electrical properties
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