Cardiovascular Health in Pregnant Women and Their Children - The Generation R Study

__Abstract__ Cardiovascular disease is a major public health problem in the general adult population. 1 Cardiovascular disease leads to over 17.3 million deaths per year and is the leading cause of death and disability worldwide.1 In the Netherlands, cardiovascular disease accounts for approximately 30% of current mortality rates among men and women.2 Because of the clinical impact that cardiovascular and metabolic diseases have at older ages, research into related risk factors has mostly been focused on adults. However, in the last decades, an accumulating body of evidence suggested that cardiovascular health in younger age groups also has major long-term public health implications

Therapeutic Vascular Compliance Change May Cause Significant Variation in Coronary Perfusion: A Numerical Study

In some pathological conditions like aortic stiffening and calcific aortic stenosis (CAS), the microstructure of the aortic root and the aortic valve leaflets are altered in response to stress resulting in changes in tissue thickness, stiffness, or both. This aortic stiffening and CAS are thought to affect coronary blood flow. The goal of the present paper was to include the flow in the coronary ostia in the previous fluid structure interaction model we have developed and to analyze the effect of diseased tissues (aortic root stiffening and CAS) on coronary perfusion. Results revealed a significant impact on the coronary perfusion due to a moderate increase in the aortic wall stiffness and CAS (increase of the aortic valve leaflets thickness). A marked drop of coronary peak velocity occurred when the values of leaflet thickness and aortic wall stiffness were above a certain threshold, corresponding to a threefold of their normal value. Consequently, mild and prophylactic treatments such as smoking cessation, exercise, or diet, which have been proven to increase the aortic compliance, may significantly improve the coronary perfusion

Three-way electrical gating characteristics of metallic Y-junction carbon nanotubes

Y-junction based carbon nanotube (CNT) transistors exhibit interesting switching behaviors, and have the structural advantage that the electrical gate for current modulation can be formed by any of the three constituent branches. In this letter, we report on the gating characteristics of metallic Y-CNT morphologies. By measuring the output conductance and transconductance we conclude that the efficiency and gain depend on the branch diameter and is electric field controlled. Based on these principles, we propose a design for a Y-junction based CNT switching device, with tunable electrical properties

Is the energy status influencing dispersion in American glass eel?

International audienceThe American eel has a facultative catadromous life cycle. Spawning occurs in Sargasso Sea and growth occurs into freshwater or saltwater habitats over a wide geographical range. The selection of suitable habitat for growth begins at the glass eel stage. Based on the hypothesis of conditional dispersion strategy, energetic status would determine whether glass eels would express freshwater or saltwater preference. Glass eels were captured from two rivers from Nova Scotia and two rivers from Québec in 2011 and 2012. Following salinity preference experiments, glass eels were classified as “inactive” or as “active with preference for fresh water” and “active with preference for salt water”. They were anaesthetized in MS 222, weighed, measured and frozen in carbonic ice. Results indicate that glass eels expressing preference for freshwater had the highest condition factor. Total content of glycogen and lipids were measured in order to test whether or not the three groups of glass eels could be differentiated based on their energy status whatever the river and the year of fishing and results will be presented