GLEBA, Gudrun, Klosterleben im Mittelalter

Cet ouvrage, destiné au grand public et pourvu d’abondantes illustrations de qualité, brosse un tableau d’ensemble de la vie au cloître (pas seulement monastique, puisqu’il traite aussi des Ordres mendiants, des Béguines et des Tiers-Ordres) pendant tout le Moyen Âge, depuis les premières formes de vie solitaire et cénobitique au IVe s., jusqu’au XVe s. Le pari est ambitieux, mais réussi : le texte, quoique très synthétique, reste clair et concret et est d’une bonne tenue scientifique. Les il..

KIER, Hiltrud, GECHTER, Marianne, Frauenklöster im Rheinland und in Westphalen

Ce petit ouvrage, préparé dans le sillage des expositions Krone und Schleier d’Essen et de Bonn, se présente sous la forme d’un guide touristique des communautés religieuses de femmes en Rhénanie et Westphalie, depuis Minden au nord jusqu’à Mayence et Trèves au sud, avec une échappée aux Pays-Bas (Susteren). Il offre 13 itinéraires de découvertes avec des cartes très lisibles et utilisables en voiture. L’ensemble est précédé d’une introduction claire et précise sur l’histoire de la vie religi..

Link between Intestinal CD36 Ligand Binding and Satiety Induced by a High Protein Diet in Mice

CD36 is a ubiquitous membrane glycoprotein that binds long-chain fatty acids. The presence of a functional CD36 is required for the induction of satiety by a lipid load and its role as a lipid receptor driving cellular signal has recently been demonstrated. Our project aimed to further explore the role of intestinal CD36 in the regulation of food intake. Duodenal infusions of vehicle or sulfo-N-succinimidyl-oleate (SSO) was performed prior to acute infusions of saline or Intralipid (IL) in mice. Infusion of minute quantities of IL induced a decrease in food intake (FI) compared to saline. Infusion of SSO had the same effect but no additive inhibitory effect was observed in presence of IL. No IL- or SSO-mediated satiety occurred in CD36-null mice. To determine whether the CD36-mediated hypophagic effect of lipids was maintained in animals fed a satietogen diet, mice were subjected to a High-Protein diet (HPD). Concomitantly with the satiety effect, a rise in intestinal CD36 gene expression was observed. No satiety effect occurred in CD36-null mice. HPD-fed WT mice showed a diminished FI compared to control mice, after saline duodenal infusion. But there was no further decrease after lipid infusion. The lipid-induced decrease in FI observed on control mice was accompanied by a rise in jejunal oleylethanolamide (OEA). Its level was higher in HPD-fed mice than in controls after saline infusion and was not changed by lipids. Overall, we demonstrate that lipid binding to intestinal CD36 is sufficient to produce a satiety effect. Moreover, it could participate in the satiety effect induced by HPD. Intestine can modulate FI by several mechanisms including an increase in OEA production and CD36 gene expression. Furthermore, intestine of mice adapted to HPD have a diminished capacity to modulate their food intake in response to dietary lipids

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock

D'Hincmar à Michel Sot : jeu de miroirs autour de l'histoire de l'Église de Reims

Gaillard Michèle. D'Hincmar à Michel Sot : jeu de miroirs autour de l'histoire de l'Église de Reims. In: Revue belge de philologie et d'histoire, tome 73, fasc. 2, 1995. Histoire medievale, moderne et contemporaine - Middeleeuwse, moderne en hedendaagse geschiedenis. pp. 401-407

« Les évêques carolingiens, fideles regis et prelati.Autour du cas « lorrain » (816-vers 925) »

International audienc

Le "petit cartulaire" de Saint-Arnoul de Metz

International audienc

François Bougard, Laurent Feller, Régine Le Jan (eds.). Dots et douaires dans le haut Moyen Âge

Gaillard Michèle. François Bougard, Laurent Feller, Régine Le Jan (eds.). Dots et douaires dans le haut Moyen Âge. In: Revue belge de philologie et d'histoire, tome 82, fasc. 4, 2004. Histoire médiévale, moderne et contemporaine - Middeleeuwse. moderne en hedendaagse geschiedenis. pp. 1065-1067

L’accueil des laïcs dans les monastères (ve-ixe siècle), d’après les règles monastiques

Through the monastic rules, written between the fifth and the ninth century, we perceive little concrete data about specific buildings reserved for the reception of laymen in the monasteries; two topographic data are intangible: on the one hand, we have an hotel reserved for people from outside the community and on the other hand we find a strictly limited space for the monastic community. But there was no necessity of an absolute separation between monks and hosts. The rules are more explicit and sometimes divergent concerning the general conditions how to receive laymen and how to organize an exchange between laymen and monks; they clearly distinguish visitors and postulants, and they often entrust the control of the two categories to the Ancients