8 research outputs found
Emerging antibody therapies for pancreatic adenocarcinoma: a review of recent phase 2 trials
Pifithrin-ÎŒ induces necroptosis through oxidative mitochondrial damage but accompanies epithelialâmesenchymal transition-like phenomenon in malignant mesothelioma cells under lactic acidosis
Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling
Solid epidemiological evidences connect obesity with incidence, stage, and survival in pancreatic cancer. However, the underlying mechanistic basis linking adipocytes to pancreatic cancer progression remain largely elusive. We hypothesized that factors secreted by adipocytes could be responsible for epithelial-to-mesenchymal transition (EMT) induction and, in turn, a more aggressive phenotype in models of pancreatic preneoplastic lesions
Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling
Why is pancreatic cancer so deadly? The pathologist's view
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