The concentration of homocysteine-derived disulfides in human coronary artery

*Background* 
Based on previous findings, we have estimated that, in injured coronary artery tissue, the low molecular weight disulfides homocystine and cysteine-homocysteine, otherwise identified as oxidized homocysteine equivalents (OHcyE), may achieve a total concentration that is higher than the aqueous solubility of homocystine at room temperature. In order to verify whether or not OHcyE could reach their saturation limit in the vascular tissue, we have measured the solubility of homocystine in physiological-like condition.

*Materials and methods* 
The solubility of homocystine has been measured in aqueous sodium chloride solutions at 37 °C by differential pulse polarography based on the reduction of homocystine to homocysteine.

*Results* 
We have estimated that the concentration achieved by OHcyE in injured coronary artery tissue is at least near-saturating, because the solubility of homocystine in physiological-like condition, above which deposition of homocystine and/or cysteine-homocysteine as solid phase occurs, almost exactly matches its value. Near-saturation levels of OHcyE within the vascular tissue means that significant leakage of intracellular fluid can promote OHcyE crystallization in tissue fluids, which may serve to initiate inflammation. 

*Conclusions* 
We speculate that deposition of OHcyE crystals could damage blood vessels and act as a primer of homocysteine-triggered inflammation, thus being along the causal pathway that leads to vascular dysfunction

Graph-based analysis of textured images for hierarchical segmentation

International audienceThe Texture Fragmentation and Reconstruction (TFR) algorithm has been recently introduced to address the problem of image segmentation by textural properties, based on a suitable image description tool known as the Hierarchical Multiple Markov Chain (H-MMC) model. TFR provides a hierarchical set of nested segmentation maps by first identifying the elementary image patterns, and then merging them sequentially to identify complete textures at different scales of observation. In this work, we propose a major modification to the TFR by resorting to a graph based description of the image content and a graph clustering technique for the enhancement and extraction of image patterns. A procedure based on mathematical morphology will be introduced that allows for the construction of a color-wise image representation by means of multiple graph structures, along with a simple clustering technique aimed at cutting the graphs and correspondingly segment groups of connected components with a similar spatial context. The performance assessment, realized both on synthetic compositions of real-world textures and images from the remote sensing domain, confirm the effectiveness and potential of the proposed method

Effectiveness of the Chebyshev Approximation in Magnetic Field Line Tracking

The tracking of magnetic field lines can be very expensive, in terms of computational burden, when the field sources are numerous and have complex geometries, especially when accuracy is a priority, because an evaluation of the field is required in many situations. In some important applications, the computational cost can be significantly reduced by using a suitable approximation of the field in the integrated regions. This paper shows how Chebyshev polynomials are well-suited for field interpolation in magnetic field-line tracking, then discusses the conditions in which they are most appropriate, and quantifies the effectiveness of parallel computing in the approximation procedures

Defining structural robustness under seismic and simultaneous actions:an application to precast RC buildings

The increasing complexity of urban systems is making robustness a crucial requirement for structural design. The paper deals with the concept of robustness of civil structures against extreme events. After a brief literature survey, a novel point of view to robustness assessment is proposed, fitting the most accepted robustness definition. The proposed approach is discussed and compared with other methodologies for quantifying structural robustness. Thus, the methodology is developed and applied to an existing precast industrial building case study, assumed to be prone to seismic and wind hazards. In particular, the case study is assumed to be located in Emilia, Italy, where a significant earthquake occurred in 2012, causing relevant damage to gravity load designed industrial buildings. Three structural options are discussed, namely a simple supported beam–column connection (gravity load designed solution) and two pinned connections (seismic designed solution), where only one of them satisfies the current structural code requirements. The results are discussed in terms of robustness quantification, by means of a robustness matrix. The authors envisage that this approach can be effectively adopted for portfolios of existing structures, to prioritize retrofitting interventions, aimed at maximizing the overall risk mitigation with limited economic resources. © 2015 Springer Science+Business Media Dordrech

Seismic Performance of Sheathed Cold-formed Shear Walls

The paper presents and discusses the results of a research on the seismic behaviour of cold-formed steel stud shear walls, sheathed with wood-based (oriented strand board) and gypsum-based (wallboard) panels. Within this activity, this paper provides the outcomes of the results of experimental (capacity evaluation) and theoretical (demand evaluation) phases of the research. Moreover, a contribution is given for the .evaluation of the strength reduction factor of this structural typology

Transitional regime control in a fully developed channel flow

Friction drag reduction is one of the main topic of investigation because of the great beneficial fallout in different engineering field. Laminar transition can be efficiently controlled using suitable flow control techniques [1]. Recent studies focused on the possibility of controlling transitional regimes in wall bounded flow have shown that the generation of streaks with appropriate intensity are able to control the transition in boundary layer. The concept of such control was shown by A1 et al. [2] using small cylinder mounted in the spanwise direction of a flat plate a zero incidence. These devices were able to generate streamwise vortices that in turn gave rise to streaks of well specific amplitude able to attenuate the transition. The paper will present results of an experimental investigation related to the transition control in a fully developed channel flow. For the streaks generation couples of convergent jets are positioned in the spanwise direction. In figure 1 the channel with the injection system are shown