Current Challenges and Future Research Perspectives on Big Data

Data is being gathered on a scale never before seen in a wide range of application fields. Based on the actual data, rather than guesswork, decisions can now be made that were previously impossible. Mobile services, their manufacturing, retail, financial amenities, and life and physical sciences are just a few of the industries now benefiting from such Big Data analysis. Data heterogeneity, scalability, timeliness, and complexity are just a few of the issues this paper tackles when it comes to big data

T-wave alternans in long QT syndrome

Long QT syndrome (LQTS) is a congenital disorder characterized by prolongation of QT interval in the electrocardiogram (ECG) and a propensity to develop ventricular arrhythmias, which may lead to syncope, cardiac arrest or sudden death. T-wave alternans (TWA), a phenomenon of beat-to-beat variability in the repolarization phase of the ventricles, has been closely associated with an increased risk of ventricular tachyarrhythmic events (VTE) and sudden cardiac death (SCD)

A Survey on Filtering Unwanted Messages from Online Social Network Users Wall Using Text Classification

ABSTRACT: -Today one of the best communication between people is using the Online social network to which they can share information. Therefore the users who are using Online Social Networks(OSN) requires control over the unwanted messages that are posted on thier walls and to avoid the unwanted content which is displayed on private space of user. OSN provide us little support to the users requirement. To provide this, we propose a system which allows OSN users to have a direct control on the messages posted on users walls. This is achieved through a flexible rule based system in which users to customize the filtering criteria to be applied to their walls, and a Machine Learning (ML) based soft classification and short text classification which automatically produce membership labels in support of content-based filtering of a unwanted messages

Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype

Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin

Gastric myeloid sarcoma - A report of two cases addressing diagnostic issues

Presented herein are two cases of gastric myeloid sarcoma to highlight the diagnostic conundrum and pointers toward accurate diagnosis in such instances. The first case was a 35-year-old man with an ulceronodular mass in the body of stomach. Multiple biopsies were reported as inconclusive chiefly due to the fact that the lamina propria infiltrate was innocuous and failed to mark with CD20 or CD3. Subsequently the patient had extensive disseminated disease which was recognized as myeloid sarcoma but patient succumbed to the disease soon. The second case was a 25-year-old boy who presented with symptoms of gastric outlet obstruction since 6 months. An endoscopy revealed diffuse gastric wall thickening which on biopsy was recognized as myeloid sarcoma but patient developed intestinal obstruction and required ileal resection for symptomatic relief, postoperative patient never recovered and succumbed to the disease. Both patients had marrow involvement by acute myeloid leukemia (AML-M2) with a normal leukocyte count in peripheral blood. Thus gastric myeloid sarcomas are prone to a delayed diagnosis chiefly due to rarity. Pathologist should think of myeloid sarcoma in a hematolymphoid appearing tumor in stomach that is CD20, CD3 negative, has avid Ki67 and shows an infiltrate chiefly centered in lamina propria

Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22)

Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD) is a subtype of mastocytosis associated commonly with myeloid neoplasms, Non-Hodgkin′s lymphoma, or other hematological neoplasms. In these conditions, mastocytosis needs to be differentiated from mast cell hyperplasia or mast cell activation states. Neoplastic nature of mastocytosis is proved either by morphology, aberrant immunophenotype, or detection of point mutation at codon-816 of c-kit gene. This is a rare entity, even more so in pediatric population. Herein, we report a case of 14-year-old girl with SM associated with acute myeloid leukemia with maturation with t(8;21). Multifocal dense infiltrate of spindle-shaped mast cells on bone marrow aspirate and biopsy with coexpression of CD2 and CD25 by flow cytometric analysis proved the SM component at the time of diagnosis and persistence at post induction status also