Dating and Digging Stratified Archaeology in Circumpolar North America : A View from Nunalleq, Southwestern Alaska

The results presented in this paper were funded by a NERC Radiocarbon Facility grant (NRCF 1917.0415), while the wider project is funded by the Arts and Humanities Research Council (AH/K006029/1). The authors wish to thank all the members of the excavation crew from the 2014 field season for their hard work in the challenging weather conditions of southwest Alaska – without their attention to detail this study would not have been possible. Additional thanks are also due to Qanirtuuq Incorporated for logistical support and warm hospitality in Quinhagak. We also wish to thank Kevin Edwards and Kate Britton, who read an earlier draft of this paper, and three anonymous reviewers for highly constructive criticism that helped us to improve the final manuscript.Peer reviewedPublisher PD

Additional file 1: of Sodium restriction in patients with cirrhotic ascites: a protocol for a systematic review

Corresponds to PRISMA-P checklist. This checklist covers reporting standards for protocol of systematic reviews. The file mentions if these have been covered by the protocol, and where in the text these items are covered

The HIVSA Workshops

<p>Adverse events.</p

Pirfenidone for Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

<div><p>Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis. In the last decades pirfenidone an anti-inflammatory and anti-fibrotic agent has shown benefit in inhibit collagen production and has also demonstrated benefit in decline progression in IPF in physiological outcomes as Forced vital capacity (FVC), in clinical outcomes such as progression free survival (PFS) and a benefit in mortality but no in clinically relevant outcomes as exacerbations or worsening of IPF. Methods: We conducted a systematic review to evaluate the effectiveness of physiological and clinical outcomes of pirfenidone compared to placebo in IPF. We performed a search with no language restriction. Two researchers performed literature search, quality assessment, data extraction and analysis. And was performed a summary of findings table following the GRADE approach. Results: We included 5 RCTs (Randomized controlled trials) in analysis. The meta-analysis resulted in a decrease in all cause-mortality (RR 0.52 IC 0.32–0.88) and IPF related mortality (RR 0.32 IC 0.14–0.75); other outcomes evaluated were worsening of IPF (RR 0.64 IC 0.50–0.83) and acute exacerbation (RR: 0.72 IC 0.30–1.66 respectively). Also there was a decrease in progression free survival (PFS) (RR 0.83 IC 0.74–0.92) compared to placebo. Conclusions: We observed significant differences in physiologic and clinically relevant outcomes such as reduction in all-cause mortality, IPF related mortality, worsening and exacerbation of IPF and PFS. So pirfenidone treatment should be considered not only for its benefits in pulmonary function tests but also by its clinically relevant outcomes.</p></div

Search strategy results and description of studies selection process.

<p>Search strategy results and description of studies selection process.</p

Does Ownership Matter? An Overview of Systematic Reviews of the Performance of Private For-Profit, Private Not-For-Profit and Public Healthcare Providers

<div><p>Introduction</p><p>Ownership of healthcare providers has been considered as one factor that might influence their health and healthcare related performance. The aim of this article was to provide an overview of what is known about the effects on economic, administrative and health related outcomes of different types of ownership of healthcare providers -namely public, private non-for-profit (PNFP) and private for-profit (PFP)- based on the findings of systematic reviews (SR).</p><p>Methods and Findings</p><p>An overview of systematic reviews was performed. Different databases were searched in order to select SRs according to an explicit comprehensive criterion. Included SRs were assessed to determine their methodological quality. Of the 5918 references reviewed, fifteen SR were included, but six of them were rated as having major limitations, so they weren't incorporated in the analyses. According to the nine analyzed SR, ownership does seem to have an effect on health and healthcare related outcomes. In the comparison of PFP and PNFP providers, significant differences in terms of mortality of patients and payments to facilities have been found, both being higher in PFP facilities. In terms of quality and economic indicators such as efficiency, there are no concluding results. When comparing PNFP and public providers, as well as for PFP and public providers, no clear differences were found.</p><p>Conclusion</p><p>PFP providers seem to have worst results than their PNFP counterparts, but there are still important evidence gaps in the literature that needs to be covered, including the comparison between public and both PFP and PNFP providers. More research is needed in low and middle income countries to understand the impact on and development of healthcare delivery systems.</p></div

Comparison 4.

<p>Acute exacerbation.</p

Risk of bias summary: review authors' judgment’s about each risk of bias item for each included study.

<p>Risk of bias summary: review authors' judgment’s about each risk of bias item for each included study.</p

Summary of adverse events.

<p>Right: Pirfenidone group; left: placebo group N.D: No data.</p><p>Summary of adverse events.</p

Comparison 7.

<p>Change on 6-minutes walked test (6MWT) distance.</p