Zinc Supplementation against Eimeria acervulina-Induced Oxidative Damage in Broiler Chickens

This study was undertaken to determine the dietary supplements of Zn containing diet on the antioxidant status in chickens experimentally infected with Eimeria acervulina. The antioxidant status was monitored via determination of MDA concentrations and erythrocyte SOD and CAT activities, as well as vitamin E, vitamin C, Cu, and Zn in liver, muscle, and serum. The results showed increased MDA (P < .05), CAT (P < .001), and decreased SOD (P < .001) in the infected birds. Significant changes in Cu and Zn concentrations and dramatically reduction of vitamin C and E concentrations in the infected chickens were found. The observed deviations in the studied enzymes and nonenzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of chickens, infected with Eimeria acervulina. Our results proved the ameliorating role of CuZn(OH)3Cl (0.170 g per kg food) against Eimeria acervulina-induced oxidative damage in infected chickens

The effect of excess dietary manganese on uninfected and Ascaridia galli infected chicks

Abstract The effect of dietary manganese from two different sources on chicks (uninfected and infected with Ascaridia galli) was studied

Coccidian Infection Causes Oxidative Damage in Greenfinches

The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research

Modulation of liver antioxidant ability under chronic fasciliasis and (Znx Cu1-x)2 (OH) 3C1

1 page.-- Contributed to: Workshop on Biological activity of Metals and Metal Compounds (Sofia, Bulgaria, Nov 2-3, 2006)The aim of the study was to assess the antioxidant status (vitamin C, E, A, zinc, copper, catalase, superoxide dismutase, glutathione peroxidase and malondialdehyde) in chronic stage of fascioliasis after treatment with Zn-Cu mixed basic salt....The study was supported by the Spanish-Bulgarian Scientific Cooperation (CSIC-BAS) — 2005BG-Sp 008.Peer reviewe

The effect of excess dietary manganese on uninfected and Ascaridia galli infected chicks

The effect of dietary manganese from two different sources on chicks (uninfected and infected with Ascaridia galli) was studied. Chick diet was supplemented with 0.9 g Mn2+ kg-1 food either in the form of MnSO4.H2O or 2Gly. MnCl2.2H2O for 20 days. Chicks were divided into six groups: group 0, control; group 1, control + MnSO4.H2O; group 2, control + 2Gly.MnCl2.2H2O; group 3, infected with A. galli; group 4, infected with A. galli + MnSO4.H2O; and group 5, infected with A. galli + 2Gly.MnCl2.2H2O. Body weight, mortality, worm burden, and liver manganese content were investigated. Excess dietary manganese increased weights and manganese level, but mortality and worm burden were unaffected. A greater bioavailability of manganese from 2Gly.MnCl2.2H2O was established.Financial support of the Ministry of Education and Science, Project Ch-551.Peer Reviewe