Recognizing greenway network for quantifying students experience on campus-based universities : assessing the campus outdoor spaces at San Diego State University

This paper evaluates the potential of creating a green infrastructure – more specifically, an urban greenway – and its contribution the students’ campus experience, with emphasis on the outdoor university activities. To achieve best value for money – particularly in the current financial climate, with severe budget cuts constraining universities – justifying investments on campus outdoor spaces such as greenways, relies on a clear demonstration of their link to the overall success of the campus. Attempts of quantify the benefits from investments on such spaces are challenged by the scarcity of studies on the relationship between students’ experience and design (and related cost) of different types of campus landscape settings. This paper fills this gap by offering a thorough examination of a variety of extant campus developments and by measuring the performance of some selected open spaces against a ‘price-tag’ mechanism. The case study of the San Diego State University has been chosen as core case study and supplemented by 16 sub-cases across California State. The assessment has been conducted through three steps. First, a site inventory of the physical characteristics and landscape features has been conducted, focusing on 7 typologies of campus outdoor spaces (COS). Second, four main use patterns (Individual-customized, Group-social, Programmed-scheduled, and Active experiences) have been assessed by calculating the intensity of use (function of the frequency and duration of use) for each of them. The data collected was based on syntax observation methods with photos and maps of COS as prompts. Third, a Campus-Experience-Score (C-E-C) has been calculated and normalized to the size and population of the university, matching it against the actual development costs of each COS setting. The C-E-C allows measuring the link between types and features of COS and related students’ experience. Findings were discussed and verified through six in-depth interviews with local and international academics and developers/practitioners. This paper offers valuable benchmark to designers and planners seeking to maximize the value for money of investments on COS such as greenways

EGFR tyrosine kinase targeted compounds

In this study, we illustrate computer aided drug design of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives as epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors. Compounds 1-5 were screened at NCI, USA, for antitumor activity against non-small cell lung cancer (NCI-H522), colon cancer (HCT-116, HCT-15 and HT29) and breast cancer (MDA-MB-468 and MDA-MB-231/ATCC) cell lines in which EGFR is overexpressed in varying levels. Results indicated that these compounds are more potent antitumor agents compared to erlotinib against HT29 and MDA-MB-231/ATCC cell lines. Compound 3 showed GI50 value of 22.3 nM against NCI-H522 cell line, while erlotinib exhibited GI50 value of 1 μM against the same cell line. In addition, these compounds were studied for their EGFR tyrosine kinase inhibitory activity. Virtual screening utilizing molecular modeling and QSAR techniques enabled the understanding of the pharmacophoric requirements for antitumor activity. Docking the designed compounds into the ATP binding site of EGFR-TK domain was done to predict the analogous binding mode of these compounds to the EGFR-TK inhibitors

Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives

A new series of thiazolylcoumarin derivatives was synthesized. The designed strategy embraced a molecular hybridization approach which involves the combination of the thiazole and coumarin pharmacophores together. The new hybrid compounds were tested for in vitro antitumor efficacy over cervical (Hela) and kidney fibroblast (COS-7) cancer cells. Compounds 5f, 5h, 5m and 5r displayed promising efficacy toward Hela cell line. In addition, 5h and 5r were found to be the most active candidates toward COS-7 cell line. The four active analogs, 5f, 5h, 5m and 5r were screened for in vivo antitumor activity over EAC cells in mice, as well as in vitro cytotoxicity toward W138 normal cells. Results illustrated that 5r has the highest in vivo activity, and that the four analogs are less cytotoxic than 5-FU toward W138 normal cells. In this study, 3D pharmacophore analysis was performed to investigate the matching pharmacophoric features of the synthesized compounds with trichostatin A. In silico studies showed that the investigated compounds meet the optimal needs for good oral absorption with no expected toxicity hazards

Nonlinear Seismic Analysis of Building - Foundation Soil Systems

This paper deals with the problem of nonlinear seismic analysis of building - foundation soil systems. The building considered is modeled as a shear - type building supported on the surface of homogeneous isotropic elastic half-space. The governing nonlinear equations of motion for the structure - soil system are solved in the time domain using the step-by-step linear acceleration method of analysis with Wilson-e modification. Different nonlinear models to simulate the behaviour of reinforced concrete under cyclic loading are used. A parametric study has been performed on a single story shear-type building with different natural frequencies supported on the surface of different soils to show the effect of different parameters on the behaviour of such structures under seismic excitation. These parameters include the type of soil, the soil conditions, the structure flexibility, and the type of analysis (elastic or inelastic). The results show that the soil rigidity, the soil layer depth, and the structure period have great influence on the response of such structures

True Integer Valued Autoregressive Model with Skellam Distribution

In the present article, we introduce a new true integer valued autoregressive model of order one TPDINAR(1) for data sets on Z and either positive or negative correlations based on the Poisson difference (Skellam) marginal distribution and using a random walk variable (It). Properties of the model are derived. We consider several methods for estimating the unknown parameters of the model, and their properties are discussed. Simulations are carried out for the performance of these estimators for illustrative purposes. Finally, the analysis of real life time series data is presented, and its performance is compared to two different INAR(1) models that may also be used over the observed data

Acute pancreatitis in children: an experience with 50 cases

Background/purpose Acute pancreatitis in childhood is not common. It can be associated with severe morbidity and mortality. The role of clinical evaluation is vital as it can be misdiagnosed easily. The objective of this study was to review the etiology, presentation, diagnosis, management, and prognosis of acute pancreatitis in children and to assess the relevance of currently available prognostic criteria.Patients and methods Fifty children with acute pancreatitis admitted to the Pediatric Surgery Unit at the Al-Azhar University Hospitals, within the period January 1998 to December 2008 were retrospectively reviewed. They were diagnosed by clinical examination, laboratory, and radiological investigations, as well as by abdominal exploration.Results There were 25 boys and 25 girls. The median age was 9 years (range: 2–17 years). In the majority of cases, the main cause of acute pancreatic was idiopathic (17 patients), followed by trauma (10 patients). Most of the patients presented with abdominal pain (10 cases), vomiting (nine cases), jaundice (five cases), and an abdominal mass in computed tomography (48 cases).Conclusion Trauma is a major cause of pancreatitis in children. Early diagnosis, close monitoring, and proper intervention are mandatory to reduce the potential morbidity and mortality.Keywords: acute pancreatitis, children, morbidity, traum

SPARC 2017 retrospect & prospects : Salford postgraduate annual research conference book of abstracts

Welcome to the Book of Abstracts for the 2017 SPARC conference. This year we not only celebrate the work of our PGRs but also the 50th anniversary of Salford as a University, which makes this year’s conference extra special. Once again we have received a tremendous contribution from our postgraduate research community; with over 130 presenters, the conference truly showcases a vibrant PGR community at Salford. These abstracts provide a taster of the research strengths of their works, and provide delegates with a reference point for networking and initiating critical debate. With such wide-ranging topics being showcased, we encourage you to exploit this great opportunity to engage with researchers working in different subject areas to your own. To meet global challenges, high impact research inevitably requires interdisciplinary collaboration. This is recognised by all major research funders. Therefore engaging with the work of others and forging collaborations across subject areas is an essential skill for the next generation of researchers

Decontamination Systems Information and Research Program

The Decontamination Systems Information and Research Program at West Virginia University consists of research and development associated with hazardous waste remediation problems at the Department of Energy complex and elsewhere. This program seeks to facilitate expedited development and implementation of solutions to the nation`s hazardous waste clean-up efforts. By a unique combination of university research and private technology development efforts, new paths toward implementing technology and speeding clean-ups are achievable. Mechanisms include aggressive industrial tie-ins to academic development programs, expedited support of small business technology development efforts, enhanced linkages to existing DOE programs, and facilitated access to hazardous waste sites. The program topically falls into an information component, which includes knowledge acquisition, technology evaluation and outreach activities and an R and D component, which develops and implements new and improved technologies. Projects began in February 1993 due to initiation of a Cooperative Agreement between West Virginia University and the Department of Energy

Biomass Ashes for Acid Mine Drainage Remediation

Acid mine drainage (AMD) is the largest environmental problem facing the world mining and processing industry because it has low pH and can contain high concentrations of potential pollutants. Biomass ash (BA) can be considered as a potential material for AMD treatment. The main goal of this work was to investigate potential use of Biomass ash of CPK-LA and PK-LA types for AMD remediation. Four UK BAs from different fuels (i.e. straw, meat and bone meal, poultry litter), synthetic AMD, and raw AMDs (Belovo and Ursk) were used for the AMD treatment experiments. Batch experiments showed that in 1 h the biomass ash from straw combustion can effectively neutralise the synthetic AMD and the Belovo AMD with removal of potential pollutants at the liquid-to-solid ratio (L/S) of 100–250 and 10–50, respectively. The biomass ashes from straw and poultry litter combustion can effectively remove pollutants from the Ursk AMD at L/S 100 and adjust pH. The metal concentrations of those treated AMDs met receiving water quality standards. Potential pollutants precipitated as carbonate/hydroxide/sulphate, co-precipitated with Fe oxyhydroxides and Ca phosphates, and appeared as new phases such as Ca, Cu, Zn phosphates and Ca, Fe phosphates. This investigation is essential for development of appropriate, environmentally friendly and economically rational waste management

Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced ≥1 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with ≥1 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not ≥5. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin.This study was sponsored by F. Hoffmann-La Roche Ltd, Basel, Switzerland. Support for third-party writing assistance for this manuscript, furnished by Blair Jarvis MSc, ELS, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland