Other Places of Invention: Computer Graphics at the University of Utah

Many chapters draw on archival records of ACM's headquarters, ACM SIGs, and ACM leaders. This volume makes a permanent contribution to documenting the history of ACM and understanding its central role in the history of computing

CRITICAL UNMAKING Toward a Queer Computation

Although media studies and digital humanities are established fields, their overlaps have not been examined in depth. This comprehensive collection fills that gap, giving readers a critical guide to understanding the array of methodologies and projects operating at the intersections of media, culture, and practice. Topics include: access, praxis, social justice, design, interaction, interfaces, mediation, materiality, remediation, data, memory, making, programming, and hacking

"Biometrics and Opacity: A Conversation"

This conversation between scholar Jacob Gaboury and artist Zach Blas explores the unique challenges posed by contemporary digital media technology to the political projects of queer, feminist, critical race, and disability studies. Asking how we might negotiate the politics of visibility in an age of pervasive surveillance, Blas and Gaboury look to the work of artists and critical thinkers who offer alternate modes of veiled, obscured, or otherwise negotiated being in the world. Focusing on Blas's own work, the conversation interrogates what Blas terms “informatic opacity” through a discussion of his Facial Weaponization Suite (2011–14), a series of biometric masks that ask who and what we make visible to technology. Looking to the face as a critical site for negotiated visibility, Blas and Gaboury draw on diverse traditions of concealment and performance to frame the contemporary politics of visibility, including the actions of the Zapatista Army of National Liberation in Chiapas, Mexico, the tactics of the global hacker group Anonymous, the politics of the veil or hijab, the use of balaclavas by Pussy Riot members based in Russia, and the performance of drag. Contrasting opacity with a number of related key terms such as privacy, invisibility, and security, Blas and Gaboury propose instead that the weaponization of the face can serve as a means to escape from the oppressive logic that attempts to control it, thus transforming the face into what is unknown, unidentified, or opaque

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically. To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact of oncogenic KRAS on the cell surface of intestinal epithelial cells. Here we show that oncogenic KRAS alters the expression of a myriad of cell-surface proteins implicated in diverse biological functions, and identify many potential surface-accessible therapeutic targets. Cell surface-based loss-of-function screens reveal that ATP7A, a copper-exporter upregulated by mutant KRAS, is essential for neoplastic growth. ATP7A is upregulated at the surface of KRAS-mutated CRC, and protects cells from excess copper-ion toxicity. We find that KRAS-mutated cells acquire copper via a non-canonical mechanism involving macropinocytosis, which appears to be required to support their growth. Together, these results indicate that copper bioavailability is a KRAS-selective vulnerability that could be exploited for the treatment of KRAS-mutated neoplasms

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essential roles in cancer cell survival and proliferation