LGI1 (leucine-rich, glioma inactivated protein 1 precursor)

Review on LGI1 (leucine-rich, glioma inactivated protein 1 precursor), with data on DNA, on the protein encoded, and where the gene is implicated

NTRK2 (neurotrophic tyrosine kinase, receptor, type 2)

Review on NTRK2 (neurotrophic tyrosine kinase, receptor, type 2), with data on DNA, on the protein encoded, and where the gene is implicated

Lack of coupling of D-2 receptors to adenylate cyclase in GH-3 cells exposed to epidermal growth factor. Possible role of a differential expression of Gi protein subtypes.

Exposure of GH-3 cells to epidermal growth factor for 4 consecutive days induced the expression of both D-2(415) and D-2(444) dopamine-receptor isoforms. Epidermal growth factor also promoted a remarkable increase in the content of Gi3 protein, which is responsible for receptor-induced activation of potassium channels in GH-3 cells. D-2 receptors in this model apparently activate a specific transducing pathway, leading to opening of potassium channels and inhibition of prolactin release by cAMP-independent mechanisms. This is shown by: 1) the selective D-2 agonist quinpirole, while inactive on vasoactive intestinal peptide-induced prolactin release, strongly inhibited the hormone secretion induced by neurotensin; 2) quinpirole, up to 100 microM, did not inhibit cAMP production evoked by vasoactive intestinal peptide both in intact cells and in broken cell membrane preparations; and 3) quinpirole and other D-2 agonists strongly potentiated Rb+ efflux when measured in a nominally calcium-free reaction solution containing 100 mM potassium (voltage-dependent component), but did not modify Rb+ efflux if measured in a reaction solution containing 1 mM calcium and 5 mM potassium (calcium-activated, cAMP-dependent component)

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (K(A) values in the low micromolar range), but surprisingly none of the new compounds displayed activity on hCA II. Some derivatives (1, 3a and 22) displayed an interesting selectivity for activating hCA I over hCA II, Va, VII and XIII

SARS-COV-2 Pandemic for Patients with Chronic Obstructive Peripheral Arterial Disease: Impact of Interruption to Access According to Gender in a Single Center Experience

Background: This retrospective study aims to evaluate the impact of interrupted services for peripheral arterial disease (PAD) patients and especially women in a single north-eastern Italian center over a period of 3 months prior to the pandemic, during the first (2020) and the second (2021) wave of contagion in northern Italy. Methods: Patients with PAD at Rutherford stages 3 to 6 that required revascularization between March 2019 and March 2021 were classified into 3 groups, according to the period of treatment: the prepandemic period, the pandemic-20 period, and the pandemic-21 period. Results: Twenty-eight patients were treated in the prepandemic period, 21 in the pandemic-20 period, and 39 in the pandemic-21 period. It was observed that in the both pandemic periods patients presented with more severe stages of limb ischemia, Rutherford 5 and 6 stages. During pandemic-20, patients underwent mostly open surgery, followed by hybrid procedures. No differences were observed between the 3 groups in major amputations, length of hospital stay, type of discharge, limb salvage and mortality. During long-term follow-up, limb salvage appeared to be significantly better in the pandemic-21 group. The gender analysis revealed a significantly reduced female proportion of overall treated patients in 2020 and 2021 compared to the prepandemic period. In the pandemic-20 this difference appears even more evident since treatments on females represented 19% of the total while in the same period of the previous year the male/female percentage was comparable (54% vs. 46%). The women admitted presented higher stages of disease and tended to have a longer hospital stay than men. At 12-month follow-up, limb salvage was similar between the 2 genders but was slightly worse in women. Conclusions: An efficient reorganization of the vascular surgery services during the pandemic period guaranteed the quality and standard of treatment offered in the preceding periods. Among patients suffering from PAD the impact of the pandemic was greater for the female gender. It is therefore important that in addition to a reorganization of hospital services to provide adequate care for patients with ACOP in the pandemic period, greater information and awareness of women

Intermittency in Branching Processes

We study the intermittency properties of two branching processes, one with a uniform and another with a singular splitting kernel. The asymptotic intermittency indices, as well as the leading corrections to the asymptotic linear regime are explicitly computed in an analytic framework. Both models are found to possess a monofractal spectrum with $\varphi_{q}=q-1$. Relations with previous results are discussed.Comment: 20 pages, UCLA93/TEP/2

Dileptons from hot heavy static photons

We compute the production rate of lepton pair by static photons at finite temperature at two-loop order. We treat the infrared region of the gluon phase space carefully by using a hard thermal loop gluon propagator. The result is free of infrared and collinear divergences and exhibits an enhancement which produces a result of order $\sim e^2 g^3$ instead of $\sim e^2 g^4$ as would be expected from ordinary perturbation theory.Comment: 14 pages, 2 figure

A faint companion around CrA-9: protoplanet or obscured binary?

Understanding how giant planets form requires observational input from directly imaged protoplanets. We used VLT/NACO and VLT/SPHERE to search for companions in the transition disc of 2MASS J19005804-3645048 (hereafter CrA-9), an accreting M0.75 dwarf with an estimated age of 1-2 Myr. We found a faint point source at $\sim$0.7'' separation from CrA-9 ($\sim$108 au projected separation). Our 3-epoch astrometry rejects a fixed background star with a $5\sigma$ significance. The near-IR absolute magnitudes of the object point towards a planetary-mass companion. However, our analysis of the 1.0-3.8$\mu$m spectrum extracted for the companion suggests it is a young M5.5 dwarf, based on both the 1.13-$\mu$m Na index and comparison with templates of the Montreal Spectral Library. The observed spectrum is best reproduced with high effective temperature ($3057^{+119}_{-36}$K) BT-DUSTY and BT-SETTL models, but the corresponding photometric radius required to match the measured flux is only $0.60^{+0.01}_{-0.04}$ Jovian radius. We discuss possible explanations to reconcile our measurements, including an M-dwarf companion obscured by an edge-on circum-secondary disc or the shock-heated part of the photosphere of an accreting protoplanet. Follow-up observations covering a larger wavelength range and/or at finer spectral resolution are required to discriminate these two scenarios.Comment: 24 pages, 14 figures, 4 tables, to be published in MNRA

Tephra sedimentation and grainsize associated with pulsatory activity: the 2021 Tajogaite eruption of Cumbre Vieja (La Palma, Canary Islands, Spain)

Long-lasting eruptions are of complex characterization and are typically associated with challenging risk assessment and crisis management due to the usual occurrence of multiple interacting hazards evolving at different temporal and spatial scales (e.g., lava, tephra, and gas). The 2021 Tajogaite eruption of Cumbre Vieja (La Palma) demonstrated how even hybrid events that are mostly effusive can be associated with widespread and impacting tephra deposits as a result of a complex interplay among gas flux, conduit geometry, and magma feeding rate. In this novel study, direct observations, syn-eruptive and post-eruptive sampling, and statistical analysis of pulsatory activity have been combined to provide new insights into eruption dynamics. They show how rapid gas segregation and high magma ascent rate modulated the gas flux at multiple vents, resulting in short-time fluctuations among the different explosive styles (ash-poor gas puffing, Strombolian, violent Strombolian, and lava fountaining) and unsteady tephra ground accumulation. Various size-selective sedimentation processes were also observed, including particle aggregation and ash fingers, which have impacted the overall tephra dispersal. In fact, even though both local and total grainsize distributions of selected layers, units, and of the whole tephra blanket are unimodal with a low fine-ash content, grainsize analysis of 154 samples suggests no correlation of particles <63 μm with distance from vents. Our analyses demonstrate the need to include a detailed characterization of all products of hybrid eruptions for a comprehensive interpretation of eruptive dynamics and to use multiple classification strategies that can capture eruptive styles at different temporal scales