Torakalna hernijacija kralješnične moždine

Herniation of the spinal cord through a dural defect is a rather rare deformity and very easily misdiagnosed as retromedullary occult intraspinal arachnoid cyst or meningocele. The possible origin of the dural defect can be traumatic, iatrogenic or unknown, so in these cases, congenital with great probability. On the thoracal part of the spinal column it shows a rather characteristic and misleading appearance. The anomaly leads to progressive Brown-Sequard syndrome, and the case history can be extremely long. Surgical repair of the dural defect results in improvement, or even complete recovery, if performed in time. These are the facts that emphasize the importance of early diagnosis.Hernijacija kralježnične moždine kroz duralne defekte prilično je rijetka deformacija koja se vrlo lako pogrešno dijagnosticira kao retromedularna okultna intraspinalna arahnoidna cista ili kao meningokela. Uzrok duralnog defekta može biti traumatski, jatrogeni ili nepoznat, a u ovim je slučajevima vrlo vjerojatno prirođen. Torakalni dio kralježnice pokazuje prilično karakterističan izgled, no koji može zavarati. Poremećaj uzrokuje pojavu progresivnog Brown-Séquardova sindroma, a anamneza može biti izrazito dugotrajna. Ako se provede na vrijeme, kirurško zatvaranje duralnog defekta dovodi do poboljšanja, pa čak i do potpunog oporavka, .to upućuje na važnost rane dijagnoze

Antiviral Silencing and Suppression of Gene Silencing in Plants

RNA silencing is an evolutionary conserved sequence-specific gene inactivation mechanism that contributes to the control of development, maintains heterochromatin, acts in stress responses, DNA repair and defends against invading nucleic acids like transposons and viruses. In plants RNA silencing functions as one of the main immune systems. RNA silencing process involves the small RNAs and trans factor components like Dicers, Argonautes and RNA-dependent RNA poly- merases. To deal with host antiviral silencing responses viruses evolved mecha- nisms to avoid or counteract this, most notably through expression of viral suppressors of RNA silencing. Due to the overlap between endogenous and antiviral silencing pathways while blocking antiviral pathways viruses also impact endogenous silencing processes. Here we provide an overview of antiviral silencing pathway, host factors implicated in it and the crosstalk between antiviral and endogenous branches of silencing. We summarize the current status of knowledge about the viral counter-defense strategies acting at various steps during virus infection in plants with the focus on representative, well studied silencing suppres- sor proteins. Finally we discuss future challenges of the antiviral silencing and counter-defense research field