沿海地区dinsar形变探测 : 精度与可应用性分析

Author name used in this publication: 刘国祥Author name used in this publication: 丁晓利, DING Xiao-liTitle in Traditional Chinese: 沿海地區DInSAR形變探測:精度與可應用性分析Journal title in Traditional Chinese: 測繪通報2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

PS-DInSAR公共主影像的优化选取

Author name used in this publication: 陈强Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 刘国祥Title in Traditional Chinese: PS-DInSAR公共主影像的優化選取Journal title in Traditional Chinese: 測繪學報2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

干涉雷达永久散射体自动探测——算法与实验结果

Author name used in this publication: 陈强Author name used in this publication: 刘国祥Author name used in this publication: 李永树Author name used in this publication: 丁晓利, DING Xiao-liTitle in Traditional Chinese: 干涉雷達永久散射體自動探測——演算法與實驗結果Journal title in Traditional Chinese: 測繪學報2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

永久散射体雷达差分干涉应用于区域地表沉降探测

Author name used in this publication: 陈强Author name used in this publication: 刘国祥Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 李永树Title in Traditional Chinese: 永久散射體雷達差分干涉應用于區域地表沉降探測Journal title in Traditional Chinese: 地球物理學報2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

星载SAR复数图像的配准

Author name used in this publication: 刘国祥Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 陈永奇Author name used in this publication: 章国宝Title in Traditional Chinese: 星載SAR複數圖像的配准Journal title in Traditional Chinese: 測繪學報2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

使用InSAR建立DEM的试验研究

Author name used in this publication: 刘国祥Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 陈永奇Author name used in this publication: 李志伟, LI Zhi-weiTitle in Traditional Chinese: 使用InSAR建立DEM的試驗研究Journal title in Traditional Chinese: 測繪學報Author name used in this publication: LI Zhi-lin2001-2002 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

InSAR DEM的质量评价

Author name used in this publication: 刘国祥Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 李志林Author name used in this publication: 陈永奇Author name used in this publication: 刘文熙Author name used in this publication: 李志伟Title in Traditional Chinese: InSAR DEM的質量評價Journal title in Traditional Chinese: 遥感信息2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Testing and comparing two self-care-related instruments among older Chinese adults

Objectives The study aimed to test and compare the reliability and validity, including sensitivity and specificity of the two self-care-related instruments, the Self-care Ability Scale for the Elderly (SASE), and the Appraisal of Self-care Agency Scale-Revised (ASAS-R), among older adults in the Chinese context. Methods A cross-sectional design was used to conduct this study. The sample consisted of 1152 older adults. Data were collected by a questionnaire including the Chinese version of SASE (SASE-CHI), the Chinese version of ASAS-R (ASAS-R-CHI) and the Exercise of Self-Care Agency scale (ESCA). Homogeneity and stability, content, construct and concurrent validity, and sensitivity and specificity were assessed. Results The Cronbach's alpha (α) of SASE-CHI was 0.89, the item-to-total correlations ranged from r = 0.15 to r = 0.81, and the test-retest correlation coefficient (intra-class correlation coefficient, ICC) was 0.99 (95% CI, 0.99±1.00; P<0.001). The Cronbach's α of ASAS-R-CHI was 0.78, the item-to-total correlations ranged from r = 0.20 to r = 0.65, and the test-retest ICC was 0.95 (95% CI, 0.92±0.96; P<0.001). The content validity index (CVI) of SASE-CHI and ASAS-R-CHI was 0.96 and 0.97, respectively. The findings of exploratory and confirmatory factor analyses (EFA and CFA) confirmed a good construct validity of SASE-CHI and ASAS-R-CHI. The Pearson's rank correlation coefficients, as a measure of concurrent validity, between total score of SASE-CHI and ESCA and ASAS-R-CHI and ESCA were assessed to 0.65 (P<0.001) and 0.62 (P<0.001), respectively. Regarding ESCA as the criterion, the area under the receiver operator characteristic (ROC) curve for the cut-point of SASE-CHI and ASAS-R-CHI were 0.93 (95% CI, 0.91±0.94) and 0.83 (95% CI, 0.80±0.86), respectively. Conclusion There is no significant difference between the two instruments. Each has its own characteristics, but SASE-CHI is more suitable for older adults. The key point is that the users can choose the most appropriate scale according to the specific situation.publishedVersionNivå

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic ß-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabolism, we aimed to address the hypothesis that GLP-1 receptor (GLP-1R) signalling can modulate glucose uptake and utilization in ß-cells. We have assessed various metabolic parameters after short and long exposure of clonal BRIN-BD11 ß-cells and rodent islets to the GLP-1R agonist Exendin-4 (50 nM). Here we report for the first time that prolonged stimulation of the GLP-1R for 18 hours promotes metabolic reprogramming of ß-cells. This is evidenced by up-regulation of glycolytic enzyme expression, increased rates of glucose uptake and consumption, as well as augmented ATP content, insulin secretion and glycolytic flux after removal of Exendin-4. In our model, depletion of Hypoxia-Inducible Factor 1 alpha (HIF-1a) impaired the effects of Exendin-4 on glucose metabolism, while pharmacological inhibition of Phosphoinositide 3-kinase (PI3K) or mTOR completely abolished such effects. Considering the central role of glucose catabolism for stimulus-secretion coupling in ß-cells, our findings suggest that chronic GLP-1 actions on insulin secretion include elevated ß-cell glucose metabolism. Moreover, our data reveal novel aspects of GLP-1 stimulated insulin secretion involving de novo gene expression