748 research outputs found
Rotating Higher Spin Partition Functions and Extended BMS Symmetries
We evaluate one-loop partition functions of higher-spin fields in thermal
flat space with angular potentials; this computation is performed in arbitrary
space-time dimension, and the result is a simple combination of Poincar\'e
characters. We then focus on dimension three, showing that suitable products of
one-loop partition functions coincide with vacuum characters of higher-spin
asymptotic symmetry algebras at null infinity. These are extensions of the
bms_3 algebra that emerges in pure gravity, and we propose a way to build their
unitary representations and to compute the associated characters. We also
extend our investigations to supergravity and to a class of gauge theories
involving higher-spin fermionic fields.Comment: 58 pages; clarifications and references added; version to be
published in JHE
Infections with Avian Pathogenic and Fecal Escherichia coli Strains Display Similar Lung Histopathology and Macrophage Apoptosis
The purpose of this study was to compare histopathological changes in the lungs of chickens infected with avian
pathogenic (APEC) and avian fecal (Afecal) Escherichia coli strains, and to analyze how the interaction of the bacteria with
avian macrophages relates to the outcome of the infection. Chickens were infected intratracheally with three APEC strains,
MT78, IMT5155, and UEL17, and one non-pathogenic Afecal strain, IMT5104. The pathogenicity of the strains was assessed by
isolating bacteria from lungs, kidneys, and spleens at 24 h post-infection (p.i.). Lungs were examined for histopathological
changes at 12, 18, and 24 h p.i. Serial lung sections were stained with hematoxylin and eosin (HE), terminal deoxynucleotidyl
dUTP nick end labeling (TUNEL) for detection of apoptotic cells, and an anti-O2 antibody for detection of MT78 and
IMT5155. UEL17 and IMT5104 did not cause systemic infections and the extents of lung colonization were two orders of
magnitude lower than for the septicemic strains MT78 and IMT5155, yet all four strains caused the same extent of
inflammation in the lungs. The inflammation was localized; there were some congested areas next to unaffected areas. Only
the inflamed regions became labeled with anti-O2 antibody. TUNEL labeling revealed the presence of apoptotic cells at 12 h
p.i in the inflamed regions only, and before any necrotic foci could be seen. The TUNEL-positive cells were very likely dying
heterophils, as evidenced by the purulent inflammation. Some of the dying cells observed in avian lungs in situ may also be
macrophages, since all four avian E. coli induced caspase 3/7 activation in monolayers of HD11 avian macrophages. In
summary, both pathogenic and non-pathogenic fecal strains of avian E. coli produce focal infections in the avian lung, and
these are accompanied by inflammation and cell death in the infected areas
Distributions of charged massive scalars and fermions from evaporating higher-dimensional black holes
A detailed numerical analysis is performed to obtain the Hawking spectrum for
charged, massive brane scalars and fermions on the approximate background of a
brane charged rotating higher-dimensional black hole constructed in
arXiv:0907.5107. We formulate the problem in terms of a "spinor-like" first
order system of differential wave equations not only for fermions, but for
scalars as well and integrate it numerically. Flux spectra are presented for
non-zero mass, charge and rotation, confirming and extending previous results
based on analytic approximations. In particular we describe an inverted charge
splitting at low energies, which is not present in four or five dimensions and
increases with the number of extra dimensions. This provides another signature
of the evaporation of higher-dimensional black holes in TeV scale gravity
scenarios.Comment: 19 pages, 6 figures, minor typos corrected, 1 page added with a
discussion on higher spins, added reference
Fine mapping of genetic polymorphisms of pulmonary tuberculosis within chromosome 18q11.2 in the Chinese population: a case-control study
<p>Abstract</p> <p>Background</p> <p>Recently, one genome-wide association study identified a susceptibility locus of rs4331426 on chromosome 18q11.2 for tuberculosis in the African population. To validate the significance of this susceptibility locus in other areas, we conducted a case-control study in the Chinese population.</p> <p>Methods</p> <p>The present study consisted of 578 cases and 756 controls. The SNP rs4331426 and other six tag SNPs in the 100 Kbp up and down stream of rs4331426 on chromosome 18q11.2 were genotyped by using the Taqman-based allelic discrimination system.</p> <p>Results</p> <p>As compared with the findings from the African population, genetic variation of the SNP rs4331426 was rare among the Chinese. No significant differences were observed in genotypes or allele frequencies of the tag SNPs between cases and controls either before or after adjusting for age, sex, education, smoking, and drinking history. However, we observed strong linkage disequilibrium of SNPs. Constructed haplotypes within this block were linked the altered risks of tuberculosis. For example, in comparison with the common haplotype AA<sub>(rs8087945-rs12456774)</sub>, haplotypes AG<sub>(rs8087945-rs12456774) </sub>and GA<sub>(rs8087945-rs12456774) </sub>were associated with a decreased risk of tuberculosis, with the adjusted odds ratio(95% confidence interval) of 0.34(0.27-0.42) and 0.22(0.16-0.29), respectively.</p> <p>Conclusions</p> <p>Susceptibility locus of rs4331426 discovered in the African population could not be validated in the Chinese population. None of genetic polymorphisms we genotyped were related to tuberculosis in the single-point analysis. However, haplotypes on chromosome 18q11.2 might contribute to an individual's susceptibility. More work is necessary to identify the true causative variants of tuberculosis.</p
Membranes by the Numbers
Many of the most important processes in cells take place on and across
membranes. With the rise of an impressive array of powerful quantitative
methods for characterizing these membranes, it is an opportune time to reflect
on the structure and function of membranes from the point of view of biological
numeracy. To that end, in this article, I review the quantitative parameters
that characterize the mechanical, electrical and transport properties of
membranes and carry out a number of corresponding order of magnitude estimates
that help us understand the values of those parameters.Comment: 27 pages, 12 figure
Optimal electromagnetic hybrid negative current compensation method for high-speed railway power supply system
Variational Methods for Biomolecular Modeling
Structure, function and dynamics of many biomolecular systems can be
characterized by the energetic variational principle and the corresponding
systems of partial differential equations (PDEs). This principle allows us to
focus on the identification of essential energetic components, the optimal
parametrization of energies, and the efficient computational implementation of
energy variation or minimization. Given the fact that complex biomolecular
systems are structurally non-uniform and their interactions occur through
contact interfaces, their free energies are associated with various interfaces
as well, such as solute-solvent interface, molecular binding interface, lipid
domain interface, and membrane surfaces. This fact motivates the inclusion of
interface geometry, particular its curvatures, to the parametrization of free
energies. Applications of such interface geometry based energetic variational
principles are illustrated through three concrete topics: the multiscale
modeling of biomolecular electrostatics and solvation that includes the
curvature energy of the molecular surface, the formation of microdomains on
lipid membrane due to the geometric and molecular mechanics at the lipid
interface, and the mean curvature driven protein localization on membrane
surfaces. By further implicitly representing the interface using a phase field
function over the entire domain, one can simulate the dynamics of the interface
and the corresponding energy variation by evolving the phase field function,
achieving significant reduction of the number of degrees of freedom and
computational complexity. Strategies for improving the efficiency of
computational implementations and for extending applications to coarse-graining
or multiscale molecular simulations are outlined.Comment: 36 page
Synthesis and Photoluminescence Property of Silicon Carbide Nanowires Via Carbothermic Reduction of Silica
Silicon carbide nanowires have been synthesized at 1400 °C by carbothermic reduction of silica with bamboo carbon under normal atmosphere pressure without metallic catalyst. X-ray diffraction, scanning electron microscopy, energy-dispersive spectroscopy, transmission electron microscopy and Fourier transformed infrared spectroscopy were used to characterize the silicon carbide nanowires. The results show that the silicon carbide nanowires have a core–shell structure and grow along <111> direction. The diameter of silicon carbide nanowires is about 50–200 nm and the length from tens to hundreds of micrometers. The vapor–solid mechanism is proposed to elucidate the growth process. The photoluminescence of the synthesized silicon carbide nanowires shows significant blueshifts, which is resulted from the existence of oxygen defects in amorphous layer and the special rough core–shell interface
Gender-based acute outcome in percutaneous coronary intervention of chronic total coronary occlusion
A Variational Deduction of Second Gradient Poroelasticity Part I: General Theory
Second gradient theories have to be used to capture how local micro
heterogeneities macroscopically affect the behavior of a continuum. In this
paper a configurational space for a solid matrix filled by an unknown amount of
fluid is introduced. The Euler-Lagrange equations valid for second gradient
poromechanics, generalizing those due to Biot, are deduced by means of a
Lagrangian variational formulation. Starting from a generalized Clausius-Duhem
inequality, valid in the framework of second gradient theories, the existence
of a macroscopic solid skeleton Lagrangian deformation energy, depending on the
solid strain and the Lagrangian fluid mass density as well as on their
Lagrangian gradients, is proven.Comment: 20 page
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