The past, present, and future of the Brain Imaging Data Structure (BIDS)

The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, the mechanisms by which it has been extended, and some of the challenges being addressed as it evolves. We also discuss the lessons learned through the project, with the aim of enabling researchers in other domains to learn from the success of BIDS

Online learning and adaptation of patient support during ADL training

Neurological patients with impaired upper limbs often receive arm therapy to restore or relearn lost motor functions. During the last years robotic devices were developed to assist the patient during the training. In daily life the diversity of movements is large because the human arm has many degrees of freedom and is used as a manipulandum to interact with the environment. To support a patient during the training the amount of support should be adapted in an assist-as-needed manner. We propose a method to learn the arm support needed during the training of activities of daily living (ADL) with an arm rehabilitation robot. The model learns the performance of the patient and creates an impairment space with a radial basis function network that can be used to assist the patient together with a patient-cooperative control strategy. Together with the arm robot ARMin the learning algorithm was evaluated. The results showed that the proposed model is able to learn the required arm support for different movements during ADL training. © 2011 IEEE

Cellular mechanisms underlying the interaction between cannabinoid and opioid system

Recently, the presence of functional interaction between the opioid and cannabinoid system has been shown in various pharmacological responses. Although there is an increasing interest for the feasible therapeutic application of a co-administration of cannabinoids and opioids in some disorders (i.e. to manage pain, to modulate immune system and emotions) and the combined use of the two drugs by drug abusers is becoming largely diffuse, only few papers focused on cellular and molecular mechanisms underlying this interaction. This review updates the biochemical and molecular underpinnings of opioid and cannabinoid interaction, both within the central nervous system and periphery. The most convincing theory for the explanation of this reciprocal interaction involves (i) the release of opioid peptides by cannabinoids or endocannabinoids by opioids, (ii) the existence of a direct receptor-receptor interaction when the receptors are co-expressed in the same cells, and (iii) the interaction of their intracellular pathways. Finally, the cannabinoid/opioid interaction might be different in the brain rewarding networks and in those accounting for other pharmacological effects (antinociception, modulation of emotionality and cognitive behavior), as well as between the central nervous system and periphery. Further insights about the cannabinoid/opioid interaction could pave the way for new and promising therapeutic approaches