Food metabolomics applied in cohorts to accelerate the discovery of nutritional biomarkers

communication orale : Claudine ManachThe Second International Congress of Translational Research in Human Nutrition is organised by the Research Centre in Human Nutrition (CRNH) of Auvergne, of which INRA is a member, in collaboration with NuGO, European Association of universities and research institutes in the field of nutrigenomics.The purpose of dietary assessment is to estimate usual and recent intake of foods, nutrients, bioactive compounds and food contaminants for exploration of associations with health outcomes and monitoring of population nutritional status. These data are still extremely difficult to obtain. Methods currently used are based on dietary questionnaires which have inherent limitations linked to self-reporting. A complementary approach to questionnaires is the use of biomarkers. However, only a few biomarkers have been properly validated, which do not cover the wide range offoods consumed. Metabolomics has emerged as a promising approach to discover nutritional biomarkers. Typically, plasma or urine samples collected before and after acute intake of a specific food are profiled using NMR or high resolution Mass Spectrometry (MS) and compared usingmultivariate statistics to pinpoint the signals reflecting the consumption of the target food. In a proof-of-concept study on citrus, we showed that urine profiling of cohort subjects stratified by consumption could be a more effective strategy for discovery of sensitive biomarkers of intake

Use of high resolution mass spectrometry for identification of specific biomarkers of coffee consumption

Présentation poster : Y. FillâtreThe Second International Congress of Translational Research in Human Nutrition is organised by the Research Centre in Human Nutrition (CRNH) of Auvergne, of which INRA is a member, in collaboration with NuGO, European Association of universities and research institutes in the field of nutrigenomicsANR Phenomenep ALIA-2010-007 Conseil Regional Auvergne-FEDER post-doc grantAs part of the ANR PhenoMeNEp project, non-targeted profiling is used to identify potential biomarkers of plant food consumption. Using 24 hour dietary recall and food frequency questionnaire data, 144 high (median 974 grams/day) and 66 low (median 305 grams/day) consumers of fruit and vegetables were selected from the French SU.VI.MAX2 cohort. Morning spot urine samples from each subjec

A metabolomics approach to identify biomarkers of coffee consumption in subjects from the SU.VI.MAX2 cohort

National audienc

Advances in food metabolomics on SU.VI.MAX2 cohort for discovery of plant food intake biomarkers

International audienc

Comparison of the urine metabolomes of stratified SUVIMAX2 subjects to identify biomarkers of fruit and vegetable intake

International audienc

New biomarkers of coffee consumption identified by non targeted metabolomic profiling in cohort study subjects

International audienc