Modular hybrid total hip arthroplasty. Experimental study in dogs

Background: This prospective experimental study evaluated the surgical procedure and results of modular hybrid total hip arthroplasty in dogs.Methods: Ten skeletally mature healthy mongrel dogs with weights varying between 19 and 27 kg were used. Cemented modular femoral stems and uncemented porous-coated acetabular cups were employed. Clinical and radiographic evaluations were performed before surgery and at 30, 60, 90, 120, 180 and 360 days post-operation.Results: Excellent weight bearing was noticed in the operated limb in seven dogs. Dislocation followed by loosening of the prosthesis was noticed in two dogs, which were therefore properly treated with a femoral head osteotomy. Femoral fracture occurred in one dog, which was promptly treated with full implant removal and femoral osteosynthesis.Conclusions: The canine modular hybrid total hip arthroplasty provided excellent functionality of the operated limb

Functional MRI evidence for the decline of word retrieval and generation during normal aging

International audienceThis fMRI study aimed to explore the effect of normal aging on word retrieval and generation. The question addressed is whether lexical production decline is determined by a direct mechanism, which concerns the language operations or is rather indirectly induced by a decline of executive functions. Indeed, the main hypothesis was that normal aging does not induce loss of lexical knowledge, but there is only a general slowdown in retrieval mechanisms involved in lexical processing , due to possible decline of the executive functions. We used three tasks (verbal fluency, object naming , and semantic categorization). Two groups of participants were tested (Young, Y and Aged, A), without cognitive and psychiatric impairment and showing similar levels of vocabulary. Neuropsychological testing revealed that older participants had lower executive function scores, longer processing speeds, and tended to have lower verbal fluency scores. Additionally, older participants showed higher scores for verbal automa-tisms and overlearned information. In terms of behav-ioral data, older participants performed as accurate as younger adults, but they were significantly slower for the semantic categorization and were less fluent for verbal fluency task. Functional MRI analyses suggested that older adults did not simply activate fewer brain regions involved in word production, but they actually showed an atypical pattern of activation. Significant correlations between the BOLD (Blood Oxygen Level Dependent) signal of aging-related (A > Y) regions and cognitive scores suggested that this atypical pattern of the activation may reveal several compensatory mechanisms (a) to overcome the slowdown in retrieval, due to the decline of executive functions and processing speed and (b) to inhibit verbal automatic processes. The BOLD signal measured in some other aging-dependent regions did not correlate with the behavioral and neuro-psychological scores, and the overactivation of these uncorrelated regions would simply reveal dedifferentia-tion that occurs with aging. Altogether, our results suggest that normal aging is associated with a more difficult access to lexico-semantic operations and representations by a slowdown in executive functions, without any conceptual loss

Swing-through gait with free-knees produced by surface functional electrical stimulation

The swing-through gait is often the gait of choice for those crutch walkers who can perform it. However, a practical (sufficiently low energy and sufficiently fast) gait is usually not achievable by paraplegic individuals with thoracic lesions. Functional electrical stimulation (FES) was used to assist three spinal cord injured (SCI) subjects with complete thoracic lesions at T11, T11 and T6 to ambulate with a swing-through gait patten. Eight channels of surface stimulation were used to bilaterally stimulate knee extensors, knee flexors, hip extensors and hip flexors. The stimulation sequence was controlled by a computer that implemented a finite-state, rule-based control strategy according to sensor inputs. Over a long, level walkway, the T11 subjects averaged 0.40 m/s and 0.38 m/s for distances of 56 m and 51 m; the T6 subject averaged 0.30 m/s for 43 m. Using a motion analysis system, the gait patterns of two of the subjects were compared to those of a trained, non-impaired subject. The SCI subjects spent more time in both double support phases (when both crutches and both feet contact the floor) than did the non-impaired subjects, leading to a loss of momentum and hence a slower and less efficient gait. In conclusion, an FES assisted swing-through gait is shown to be a potentially useful mode of FES gait