How Observations of Circumstellar Disk Asymmetries Can Reveal Hidden Planets: Pericenter Glow and its Application to the HR 4796 Disk

Recent images of the disks of dust around the young stars HR 4796A and Fomalhaut show, in each case, a double-lobed feature that may be asymmetric (one lobe may be brighter than the other). A symmetric double-lobed structure is that expected from a disk of dust with a central hole that is observed nearly edge-on (i.e., close to the plane of the disk). This paper shows how the gravitational influence of a second body in the system with an eccentric orbit would cause a brightness asymmetry in such a disk by imposing a "forced eccentricity" on the orbits of the constituent dust particles, thus shifting the center of symmetry of the disk away from the star and causing the dust near the forced pericenter of the perturbed disk to glow. Dynamic modeling of the HR 4796 disk shows that its 5% brightness asymmetry could be the result of a forced eccentricity as small as 0.02 imposed on the disk by either the binary companion HR 4796B, or by an unseen planet close to the inner edge of the disk. Since it is likely that a forced eccentricity of 0.01 or higher would be imposed on a disk in a system in which there are planets, but no binary companion, the corresponding asymmetry in the disk's structure could serve as a sensitive indicator of these planets that might otherwise remain undetected.Comment: 61 pages, 10 figures, accepted for publication in the Astrophysical Journal (scheduled for January 10, 2000

Deep 10 and 18 micron Imaging of the HR 4796A Circumstellar Disk: Transient Dust Particles & Tentative Evidence for a Brightness Asymmetry

We present new 10.8 and 18.2 micron images of HR 4796A, a young A0V star that was recently discovered to have a spectacular, nearly edge-on, circumstellar disk prominent at ~20 microns (Jayawardhana et al. 1998; Koerner et al. 1998). These new images, obtained with OSCIR at Keck II, show that the disk's size at 10 microns is comparable to its size at 18 microns. Therefore, the 18 micron-emitting dust may also emit some, or all, of the 10 micron radiation. Using these multi-wavelength images, we determine a "characteristic" diameter of 2-3 microns for the mid-infrared-emitting dust particles if they are spherical and composed of astronomical silicates. Particles this small are expected to be blown out of the system by radiation pressure in a few hundred years, and therefore these particles are unlikely to be primordial. Dynamical modeling of the disk (Wyatt et al. 2000) indicates that the disk surface density is relatively sharply peaked near 70 AU, which agrees with the mean annular radius deduced by Schneider et al. (1999) from their NICMOS images. We present evidence (~1.8 sigma significance) for a brightness asymmetry that may result from the presence of the hole and the gravitational perturbation of the disk particle orbits by the low-mass stellar companion or a planet. This "pericenter glow," which must still be confirmed, results from a very small (a few AU) shift of the disk's center of symmetry relative to the central star HR 4796A; one side of the inner boundary of the annulus is shifted towards HR 4796A, thereby becoming warmer and more infrared-emitting. The possible detection of pericenter glow implies that the detection of even complex dynamical effects of planets on disks is within reach.Comment: 18 pages. 9 GIF images. Total size ~800 kB. High resolution images available upon request. Accepted for publication in the Astrophysical Journal (scheduled for January 10, 2000

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Spitzer Mid-IR Spectra of Dust Debris Around A and Late B Type Stars: Asteroid Belt Analogs and Power-Law Dust Distributions

Using the Spitzer/Infrared Spectrograph (IRS) low-resolution modules covering wavelengths from 5 to 35 μm, we observed 52 main-sequence A and late B type stars previously seen using Spitzer/Multiband Imaging Photometer (MIPS) to have excess infrared emission at 24 μm above that expected from the stellar photosphere. The mid-IR excess is confirmed in all cases but two. While prominent spectral features are not evident in any of the spectra, we observed a striking diversity in the overall shape of the spectral energy distributions. Most of the IRS excess spectra are consistent with single-temperature blackbody emission, suggestive of dust located at a single orbital radius—a narrow ring. Assuming the excess emission originates from a population of large blackbody grains, dust temperatures range from 70 to 324 K, with a median of 190 K corresponding to a distance of 10 AU. Thirteen stars however, have dust emission that follows a power-law distribution, F_ν = F 0λ^α, with exponent α ranging from 1.0 to 2.9. The warm dust in these systems must span a greater range of orbital locations—an extended disk. All of the stars have also been observed with Spitzer/MIPS at 70 μm, with 27 of the 50 excess sources detected (signal-to-noise ratio > 3). Most 70 μm fluxes are suggestive of a cooler, Kuiper Belt-like component that may be completely independent of the asteroid belt-like warm emission detected at the IRS wavelengths. Fourteen of 37 sources with blackbody-like fits are detected at 70 μm. The 13 objects with IRS excess emission fit by a power-law disk model, however, are all detected at 70 μm (four above, three on, and six below the extrapolated power law), suggesting that the mid-IR IRS emission and far-IR 70 μm emission may be related for these sources. Overall, the observed blackbody and power-law thermal profiles reveal debris distributed in a wide variety of radial structures that do not appear to be correlated with spectral type or stellar age. An additional 43 fainter A and late B type stars without 70 μm photometry were also observed with Spitzer/IRS; results are summarized in Appendix B

Language control and parallel recovery of language in individuals with aphasia

Background: The causal basis of the different patterns of language recovery following stroke in bilingual speakers is not well understood. Our approach distinguishes the representation of language from the mechanisms involved in its control. Previous studies have suggested that difficulties in language control can explain selective aphasia in one language as well as pathological switching between languages. Here we test the hypothesis that difficulties in managing and resolving competition will also be observed in those who are equally impaired in both their languages even in the absence of pathological switching. Aims: To examine difficulties in language control in bilingual individuals with parallel recovery in aphasia and to compare their performance on different types of conflict task. Methods & procedures: Two right-handed, non-native English-speaking participants who showed parallel recovery of two languages after stroke and a group of non-native English-speaking, bilingual controls described a scene in English and in their first language and completed three explicit conflict tasks. Two of these were verbal conflict tasks: a lexical decision task in English, in which individuals distinguished English words from non-words, and a Stroop task, in English and in their first language. The third conflict task was a non-verbal flanker task. Outcomes & Results: Both participants with aphasia were impaired in the picture description task in English and in their first language but showed different patterns of impairment on the conflict tasks. For the participant with left subcortical damage, conflict was abnormally high during the verbal tasks (lexical decision and Stroop) but not during the non-verbal flanker task. In contrast, for the participant with extensive left parietal damage, conflict was less abnormal during the Stroop task than the flanker or lexical decision task. Conclusions: Our data reveal two distinct control impairments associated with parallel recovery. We stress the need to explore the precise nature of control problems and how control is implemented in order to develop fuller causal accounts of language recovery patterns in bilingual aphasia

New Debris Disks Around Nearby Main Sequence Stars: Impact on The Direct Detection of Planets

Using the MIPS instrument on the Spitzer telescope, we have searched for infrared excesses around a sample of 82 stars, mostly F, G, and K main-sequence field stars, along with a small number of nearby M stars. These stars were selected for their suitability for future observations by a variety of planet-finding techniques. These observations provide information on the asteroidal and cometary material orbiting these stars - data that can be correlated with any planets that may eventually be found. We have found significant excess 70um emission toward 12 stars. Combined with an earlier study, we find an overall 70um excess detection rate of $13 \pm 3$% for mature cool stars. Unlike the trend for planets to be found preferentially toward stars with high metallicity, the incidence of debris disks is uncorrelated with metallicity. By newly identifying 4 of these stars as having weak 24um excesses (fluxes $\sim$10% above the stellar photosphere), we confirm a trend found in earlier studies wherein a weak 24um excess is associated with a strong 70um excess. Interestingly, we find no evidence for debris disks around 23 stars cooler than K1, a result that is bolstered by a lack of excess around any of the 38 K1-M6 stars in 2 companion surveys. One motivation for this study is the fact that strong zodiacal emission can make it hard or impossible to detect planets directly with future observatories like the {\it Terrestrial Planet Finder (TPF)}. The observations reported here exclude a few stars with very high levels of emission, $>$1,000 times the emission of our zodiacal cloud, from direct planet searches. For the remainder of the sample, we set relatively high limits on dust emission from asteroid belt counterparts

Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages.

BackgroundM2-like macrophages are associated with the pathogenesis of castrate-resistant prostate cancer (CRPC). We sought to determine if dietary omega-3 fatty acids (ω-3 FAs) delay the development and progression of CRPC and inhibit tumor-associated M2-like macrophages.MethodsMycCap cells were grown subcutaneously in immunocompetent FVB mice. Mice were castrated when tumors reached 300 mm2. To study effects of dietary ω-3 FAs on development of CRPC, ω-3 or ω-6 diets were started 2 days after castration and mice sacrificed after early regrowth of tumors. To study ω-3 FA effects on progression of CRPC, tumors were allowed to regrow after castration before starting the diets. M2 (CD206+) macrophages were isolated from allografts to examine ω-3 FA effects on macrophage function. Omega-3 fatty acid effects on androgen-deprived RAW264.7 M2 macrophages were studied by RT-qPCR and a migration/ invasion assay.ResultsThe ω-3 diet combined with castration lead to greater MycCap tumor regression (tumor volume reduction: 182.2 ± 33.6 mm3) than the ω-6 diet (tumor volume reduction: 148.3 ± 35.2; p = 0.003) and significantly delayed the time to CRPC (p = 0.006). Likewise, the ω-3 diet significantly delayed progression of established castrate-resistant MycCaP tumors (p = 0.003). The ω-3 diet (as compared to the ω-6 diet) significantly reduced tumor-associated M2-like macrophage expression of CSF-1R in the CRPC development model, and matrix metallopeptidase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in the CRPC progression model. Migration of androgen-depleted RAW264.7 M2 macrophages towards MycCaP cells was reversed by addition of docosahexaenoic acid (ω-3).ConclusionsDietary omega-3 FAs (as compared to omega-6 FAs) decreased the development and progression of CRPC in an immunocompetent mouse model, and had inhibitory effects on M2-like macrophage function. Clinical trials are warranted evaluating if a fish oil-based diet can delay the time to castration resistance in men on androgen deprivation therapy, whereas further preclinical studies are warranted evaluating fish oil for more advanced CRPC