Economic and Human Features for Energy and Environmental Indicators: A Tool to Assess Countries’ Progress towards Sustainability

Energy and environmental data represent fundamental information for the analysis of sustainable development. On the other hand, these aspects should be associated with economic and human dimensions in order to obtain a more holistic vision. From this perspective, some indicators are discussed and analyzed in this paper in order to assess the performance of a country. As regards the energetic aspects, the data of total primary energy supply and exergy losses were considered. The environmental aspects were taken into account by considering the greenhouse gas emissions and the particulate matter emissions. These energy and environmental data were put in relation to the GDP (gross domestic product) and HDI (human development index, a multidimensional index proposed by United Nations), respectively. So, two sets of indicators were introduced—the set E for economic properties and the set H for human aspects. A case study was conducted by analyzing a group of countries that meet two criteria: the same macro-geographical area and comparable numbers of citizens. The European area—in particular, its six most populous countries—was chosen. From the results obtained, it is possible to point out that some countries present different rankings depending on whether set E or set H is considered. Another important aspect discussed is the temporal evolution of the indicators (the interval from 1990 to 2017 was considered). Political decision-makers can be supported by the use of the indicators of set H in order to evaluate well-being related to their choices on actions related to the energy and environment. These indicators can be used both to analyze the trends of a country and to compare them with the performance of some other similar countries

Thermal Physics and Glaucoma II: Preliminary Evidences for a Thermophysical Design of a Possible Visible-Light-Photons Therapy

Recently, a non-equilibrium thermodynamic approach has been developed in order to model the fundamental role of the membrane electric potential in the cell behaviour. A related new viewpoint is introduced, with a design of a photobiomodulation treatment in order to restore part of the visual field. Here, a first step in experimental evidence of the validity of the thermodynamic approach is developed. This result represents the starting point for future experimental improvements for light stimulation in order to improve the quality of life of the patients. The future possible therapy will be in addition to the pharmacological treatments

The impact of service and government-policy attributes on consumer preferences for electric vehicles in China

This research focuses on the effects of different types of service attributes and context-based government policies, along with product attributes, on Chinese consumers’ adoption of electric vehicles (EVs). Based on a stated choice experiment involving over 1,000 respondents in different cities of China, a mixed logit (MXL) model shows that typical product attributes are consistently important for potential car buyers, but that charging service has a mixed effect, depending on the level of service provision and speed. Specifically, the availability of a home charging facility has the strongest influence on consumers’ choice to purchase EVs, and the service speed of public fast service stations is also significant. In relation to government policies, this study finds that in addition to government subsidy, free licensing policy for EVs is very attractive for consumers, compared to the lottery-based licensing for conventional petrol vehicles (PVs). We find that Chinese consumers have the highest willingness to pay for obtaining a free vehicle license for EVs (106,144 RMB on average) and being permitted to install a home charging post (91,039 RMB on average). Our findings imply the importance of considering consumers’ perceived inconvenience associated with using EVs compared to buying and using conventional PVs. Furthermore, policy makers should consider the heterogeneous preference towards EVs when designing intervention policies in the Chinese market

Profile of idursulfase for the treatment of Hunter syndrome

Simona Sestito, Ferdinando Ceravolo, Michele Grisolia, Elisa Pascale, Licia Pensabene, Daniela Concolino Department of Pediatrics, University Magna Graecia of Catanzaro, Catanzaro, Italy Abstract: Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked lysosomal storage disorder caused by deficiency of the enzyme iduronate-2-sulfatase (IDS). Enzyme replacement therapy (ERT) with recombinant human IDS, available since 2005, is currently the most appropriate treatment for this progressive, multisystemic, chronic, and life-threatening disease. Efficacy and safety of therapy with idursulfase have been assessed in several clinical trials, and confirmed in many clinical reports. Long-term follow-up of patients receiving ERT has demonstrated the importance of an early onset of treatment with idursulfase, before irreversible pathological changes occur. Intravenously administered idursulfase is not able to cross the blood–brain barrier, so neurological signs and symptoms cannot benefit from ERT, still remaining a major challenge in the treatment of MPS II. Keywords: MPS II, glycosaminoglycans, enzyme replacement therapy, ER

Relação entre polimorfismos no gene da leptina, ganho de peso e concentração sérica de leptina em bovinos de corte.

O objetivo do trabalho é estabelecer a relação de polimorfismos no gene da leptina com a quantidade de leptina sérica e ganho de peso durante o confinamento, visando a utilização de dados obtidos em programas de seleção animal. Os bovinos confinados utilizados na pesquisa serão provenientes da Fazenda Tuju Puitan. Serão objetos da pesquisa 100 animais com idade média de 12 meses

The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection

Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group of eye conditions that progressively damage the optic nerve and impair vision. The aim of this review is to gain insight into potentially exploitable molecular mechanisms to slow down the death of retinal ganglion cells (RGCs), a fundamental element in the pathophysiology of all forms of glaucoma, and to stimulate adult optic nerve repair. For this purpose, we focus our analysis on both visible and far-red to near-infrared light photobiomodulation (PBM) as phototherapeutic agents, which were recently proposed in RGCs, and on the nerve lamina region neural progenitor cell (ONLR-NPC) niche. Both are suggested as potential strategies in glaucoma neuroprotection. We discuss the impact of beneficial molecular effects of PBM on both mitochondrial derangement and the alteration of ion fluxes that are considered important causes of RGC damage, as well as on the stimulation of progenitor cells. We suggest these are the most promising approaches to prevent excessive neuronal cell loss. We describe the experimental evidence supporting the validity of PBM therapy which, despite being a safe, non-invasive, inexpensive, and easy to administer procedure, has not yet been fully explored in the clinical practice of glaucoma treatment

Toxicity and genotoxicity of wastewater from gasoline stations

The toxicity and genotoxicity of wastewater from eight gasoline stations in Brasília, Brazil's capital city, was studied by assessing chromosomal aberrations, chromosomal malsegregation and the mitotic index in Alliumcepa root cells, and the occurrence of micronucleus and nuclear abnormalities in peripheral erythrocytes of tilapia fish (Oreochromis niloticus). The content of gasoline station effluents was also analyzed based on several physico-chemical parameters. None of the wastewater samples was genotoxic to A. cepa root cells, although cell proliferation was significantly inhibited, especially at the highest concentrations. Likewise, no micronuclei were observed in O. niloticus peripheral erythrocytes, even after exposure to high concentrations, but there was an increase in the number of nuclear abnormalities and fish mortality. These results show that although the effluent from gasoline stations is processed by an oil/water separation system before being discharged into the main sewage system, the wastewater still contains toxic compounds

Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study

BACKGROUND AND PURPOSE: Agenesis of the corpus callosum, even when isolated, may be characterized by anatomic variability. The aim of this study was to describe the types of other forebrain commissures in a large cohort of randomly enrolled fetuses with apparently isolated agenesis of the corpus callosum at prenatal MR imaging. MATERIALS AND METHODS: All fetuses with apparent isolated agenesis of the corpus callosum undergoing prenatal MR imaging from 2004 to 2014, were evaluated for the presence of the anterior or a vestigial hippocampal commissure assessed in consensus by 2 pediatric neuroradiologists. RESULTS: Overall, 62 cases of agenesis of the corpus callosum were retrieved from our data base. In 3/62 fetuses (4.8%), no forebrain commissure was visible at prenatal MR imaging, 23/62 fetuses (37.1%) presented with only the anterior commissure, and 20/62 fetuses (32.3%) showed both the anterior commissure and a residual vestigial hippocampal commissure, whereas in the remaining 16/62 fetuses (25.8%), a hybrid structure merging a residual vestigial hippocampal commissure and a rudiment of the corpus callosum body was detectable. Postnatal MR imaging, when available, confirmed prenatal forebrain commissure findings. CONCLUSIONS: Most fetuses with apparent isolated agenesis of the corpus callosum showed at least 1 forebrain commissure at prenatal MR imaging, and approximately half of fetuses also had a second commissure: a vestigial hippocampal commissure or a hybrid made of a hippocampal commissure and a rudimentary corpus callosum body. Whether such variability is the result of different genotypes and whether it may have any impact on the long-term neurodevelopmental outcome remains to be assessed. AC : anterior commissure ACC : agenesis of the corpus callosum CC : corpus callosum GA : gestational age HC : hippocampal commissure HS : hybrid structur