Tissue transglutaminase in normal and abnormal wound healing: review article

A complex series of events involving inflammation, cell migration and proliferation, ECM stabilisation and remodelling, neovascularisation and apoptosis are crucial to the tissue response to injury. Wound healing involves the dynamic interactions of multiple cells types with components of the extracellular matrix (ECM) and growth factors. Impaired wound healing as a consequence of aging, injury or disease may lead to serious disabilities and poor quality of life. Abnormal wound healing may also lead to inflammatory and fibrotic conditions (such as renal and pulmonary fibrosis). Therefore identification of the molecular events underlying wound repair is essential to develop new effective treatments in support to patients and the wound care sector. Recent advances in the understating of the physiological functions of tissue transglutaminase a multi functional protein cross-linking enzyme which stabilises tissues have demonstrated that its biological activities interrelate with wound healing phases at multiple levels. This review describes our view of the function of tissue trasnglutaminase in wound repair under normal and pathological situations and highlights its potential as a strategic therapeutic target in the development of new treatments to improve wound healing and prevent scarring

Effect on smoking quit rate of telling patients their lung age: the Step2quit randomised controlled trial

Objective To evaluate the impact of telling patients their estimated spirometric lung age as an incentive to quit smoking.Design Randomised controlled trial.Setting Five general practices in Hertfordshire, England.Participants 561 current smokers aged over 35.Intervention All participants were offered spirometric assessment of lung function. Participants in intervention group received their results in terms of "lung age" (the age of the average healthy individual who would perform similar to them on spirometry). Those in the control group received a raw figure for forced expiratory volume at one second (FEV1). Both groups were advised to quit and offered referral to local NHS smoking cessation services.Main outcome measures The primary outcome measure was verified cessation of smoking by salivary cotinine testing 12 months after recruitment. Secondary outcomes were reported changes in daily consumption of cigarettes and identification of new diagnoses of chronic obstructive lung disease.Results Follow-up was 89%. Independently verified quit rates at 12 months in the intervention and control groups, respectively, were 13.6% and 6.4% (difference 7.2%, P=0.005, 95% confidence interval 2.2% to 12.1%; number needed to treat 14). People with worse spirometric lung age were no more likely to have quit than those with normal lung age in either group. Cost per successful quitter was estimated at 280 pound ((euro) 365, $556). A new diagnosis of obstructive lung disease was made in 17% in the intervention group and 14% in the control group; a total of 16% (89/561) of participants.Conclusion Telling smokers their lung age significantly improves the likelihood of them quitting smoking, but the mechanism by which this intervention achieves its effect is unclear.Trial registration National Research Register N0096173751

SCHEDULING INPUTS WITH PRODUCTION FUNCTIONS: OPTIMAL NITROGEN PROGRAMS FOR RICE

The problem of scheduling input applications can be examined by extending conventional production function analysis. Using appropriately designed agricultural experiments, it is possible to estimate production function parameters with alternative specifications for input timing (and amount). A study of nitrogen applications to rice is employed to illustrate scheduling via production functions. Alternative specifications and functional forms are simultaneously examined to determine the sensitivity of economic results to these factors. Sensitivity is found to be high, and this finding is hypothesized to be critical for other approaches to input scheduling as well.Crop Production/Industries,

A submillimetre wavelength spectral line search of the Orion molecular cloud core

A submillimetre wavelength molecular line search of the Orion molecular cloud has been made covering a total of about 5 percent of the frequency range 342.8 - 358.6 GHz. This search, coupled with the authors' previous observations of submillimetre transitions in this cloud, has led to the detection of 22 transitions of 14 molecular species, of which 16 are reported here for the first time. No unidentified lines have been detected in the present search. Mapping observations have been obtained for several of the lines and, in the case of H2CO the authors have been able to compare the present data with that obtained from other telescopes, to estimate the density and abundance in the emitting region

Single-particle excitations in the BCS-BEC crossover region II: Broad Feshbach resonance

We apply the formulation developed in a recent paper [Y. Ohashi and A. Griffin, Phys. Rev. A {\bf 72}, 013601, (2005)] for single-particle excitations in the BCS-BEC crossover to the case of a broad Feshbach resonance. At T=0, we solve the Bogoliubov-de Gennes coupled equations taking into account a Bose condensate of bound states (molecules). In the case of a broad resonance, the density profile $n(r)$, as well as the profile of the superfluid order parameter ${\tilde \Delta}(r)$, are spatially spread out to the Thomas-Fermi radius, even in the crossover region. This order parameter ${\tilde \Delta}(r)$ suppresses the effects of low-energy Andreev bound states on the rf-tunneling current. As a result, the peak energy in the rf-spectrum is found to occur at an energy equal to the superfluid order parameter ${\tilde \Delta}(r=0)$ at the center of the trap, in contrast to the case of a narrow resonance, and in agreement with recent measurements. The LDA is found to give a good approximation for the rf-tunneling spectrum.Comment: 14 pages, 8 figure