Proposal of a Nomenclature for Hydrogeological Instability Risks and Case Studies of Conservative Soil Tillage for Environmental Protection

In order to implement environmental protection, within the Soil Cadastre, previously proposed as a multipurpose inventory that aims to promote sustainable soil uses, the hydrogeological instability caused by human activities is the focus of this work. These activities can be aimed at sustainable agricultural soil use or the building of roads to allow the access to the fields. The soil’s hydrogeological instability causes the unsustainable use and management of a cadastral parcel. Therefore, the aim of this work is to propose a nomenclature for hydrogeological instability risks, as well as the best practices of conservative soil tillage in case studies, in order to reduce environmental impact. According to the proposed Soil Cadastre, the missing environmental sustainability of a parcel and the reason for this must be communicated to the field owner or manager. In a hilly area of inland Western Sicily, four main risk types of hydrogeological instability were identified: hydrogeological instability (caused only by natural factors); hydraulic-pedological-farming instability (crop not suitable for the field for missing or insufficient soil drainage and landslides); hydraulic-infrastructural instability (built up infrastructures unsuitable for the site); hydraulic-infrastructural-pedological-management instability (field improvements changing the downflow line and crop operations not suitable for the soil and climate parameters). The farm owner or manager must be informed about the risk type affecting their fields in order to perform the best practices (i.e., conservative soil tillage), for implementing or restoring a sustainable soil use or management in each cadastral parcel

Nomenclature for Hydrogeological Instability Risks

The nomenclature for hydrogeological instability risks includes four main risks, which are distinguished according to the risk causes : 1) hydrogeological risk, that is slowly caused by natural factors (e.g. collapse landslides in a calcareous cliff in uninhabited areas and erosion along a marly-calcareous slope) in environments where human activities are minimal, i.e. woods, forests and mountain pastures; 2) hydraulic-pedological farming risk, that implies the occurrence of landslides in every winter and is caused by incorrect crop selection, not suitable for the soil and climate parameters (e.g. on a hilly slope with a clay vertisol type with a landslide having different fronts, when the arable land is cultivated with a cereal-legume crop rotation), or the presence of springs with missing drainage in clay soils with a high gradient; 3) hydraulic-infrastructural risk, that is caused by the building up of infrastructures not suitable for the surrounding environment, as they change the downflow of shallow water; 4) hydraulic-infrastructural-pedological-management risk, that is caused by crop operations not suitable for soil and crop parameters, where the selected cultivated plant species are suitable for the environment and field improvements change water downflow (e.g. in soils along hilly calcarenite slopes cultivated with olive orchards, where up-down soil tillage causes shallow water erosion)

The von Kármán street behind a circular cylinder: flow control through synthetic jet placed at the rear stagnation point

Abstrac

Influence of Machine Learning-based active flow control on the turbulent statistics of the flow over a circular cylinder

The aim of the present paper is to investigate the capabilities of Machine Learning (ML) to reduce the aerodynamic drag of a circular cylinder in cross flow, by actively controlling its wake with a synthetic jet

Effects of the stroke length and nozzle-to-plate distance on synthetic jet impingement heat transfer

This study focuses on the combined e ect of the nozzle-to-plate distance andof the stroke length on the cooling performances of impinging synthetic jets.Infrared thermography is used as temperature transducer in conjunction withthe heated thin foil heat transfer sensor to measure time- and phase-averagedconvective heat transfer...The authors wish to thank Mr. G. Sicardi for contributing the realization of the experimental setup. Carlo Salvatore Greco, Andrea Ianiro and Gennaro Cardone have been partially supported by Grant DPI2016-79401-R funded by the Spanish State Research Agency (SRA) and European Regional Development Fund (ERDF).Publicad

The Impact of GLP-1 RAs and DPP-4is on Hospitalisation and Mortality in the COVID-19 Era: A Two-Year Observational Study

Novel antidiabetic drugs have the ability to produce anti-inflammatory effects regardless of their glucose-lowering action. For this reason, these molecules (including GLP-1 RAs and DPP-4is) were hypothesized to be effective against COVID-19, which is characterized by cytokines hyperactivity and multiorgan inflammation. The aim of our work is to explore the potential protective role of GLP-1 RAs and DPP-4is in COVID-19 (with the disease intended to be a model of an acute stressor) and non-COVID-19 patients over a two-year observation period. Retrospective and one-versus-one analyses were conducted to assess the impact of antidiabetic drugs on the need for hospitalization (in both COVID-19- and non-COVID-19-related cases), in-hospital mortality, and two-year mortality. Logistic regression analyses were conducted to identify the variables associated with these outcomes. Additionally, log-rank tests were used to plot survival curves for each group of subjects, based on their antidiabetic treatment. The performed analyses revealed that despite similar hospitalization rates, subjects undergoing home therapy with GLP-1 RAs exhibited significantly lower mortality rates, even over a two-year period. These individuals demonstrated improved survival estimates both within hospital and non-hospital settings, even during a longer observation period

Apparent Treatment Resistant Hypertension, Blood Pressure Control and the Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes

Background/Aims: Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The impact of aTRH and achievement of recommended blood pressure (BP) values on the rate of glomerular filtration rate (eGFR) loss in CKD patients is poorly known. To assess the role of aTRH and time-updated BP control (BPC) on the progression of CKD in patients with T2D and hypertension (HT) in real life clinical practice. Methods: Clinical records from a total of 2,778 diabetic patients with HT and stage 3 CKD (i.e. baseline eGFR values between 30 and 60 ml/min) and regular visits during a four-year follow-up were analyzed. The association between BPC (i.e. 75% of visits with BP <140/90 mmHg) and eGFR loss (i.e. a >30% reduction from baseline) or worsening of albuminuria status over time was assessed. Results: At baseline 33% of patients had aTRH. Over the 4-year follow-up, 20% had a >30% eGFR reduction. Patients with aTRH had an increased risk of eGFR loss >30% (OR 1.31; P<0.007). In patients with aTRH, BPC was associated with a 79% (P=0.029) greater risk of eGFR reduction despite a 58% (P=0.001) lower risk of albuminuria status worsening. In non-aTRH, no association was found between BPC and renal outcome. Conclusion: In patients with stage 3 CKD the presence of aTRH entails a faster loss of eGFR. More effective prevention of aTRH should be implemented as this condition is associated with a burden of risk not modifiable by tight BP reduction

Acute Esophageal Necrosis as a Rare Complication of Metabolic Acidosis in a Diabetic Patient: A Case Report

Objective: Challenging differential diagnosisBackground: Acute esophageal necrosis, or Gurvits syndrome, is a rare clinical process often secondary to a systemic low -flow state. It can be caused by several medical conditions, and it is thought to arise from a combination of impaired mucosal barrier and chemical and ischemic insults to the esophagus. Acute esophageal necrosis usually presents with severe complications due to delayed diagnosis and only rarely has surgical indications. We present a case of Gurvits syndrome, presumably triggered by metabolic acidosis in a diabetic patient.Case Report: A 61-year-old man with history of hypertension and type 2 diabetes mellitus treated with metformin, canagliflozin, glimepiride, and pioglitazone came to our attention with persistent vomiting, odynophagia, chest pain after each meal, and progressive weight loss. Arterial blood analysis showed mild metabolic acidosis, while the first esophagogastroduodenoscopy performed revealed a circumferential black appearance of the esophageal mucosa, as in concentric necrosis of the distal esophagus with possible fungal superinfection. Brushing cytology confirmed the infection by Candida spp. and the patient was treated with intravenous fluconazole. The second esophagogastroduodenoscopy, performed after 2 weeks, showed almost complete healing of the esophageal mucosa; in this case, biopsy confirmed mucosal ischemia and necrosis, without showing deep impairment of the mucosa by fungal agents.Conclusions: Due to its high lethality, often caused by the underlying medical diseases, acute esophageal disease should be considered in the differential diagnosis of digestive symptoms, even without upper gastrointestinal bleeding. Prompt diagnosis and treatment of contextual collateral conditions can help clinicians to avoid the worst out-comes of the disease. Among the causative factors of metabolic acidosis leading to esophageal necrosis we recognized metformin and dapagliflozin

Advances in molecular preclinical therapy mediated by imaging.

Several advances have been made toward understanding the biology of cancer and most of them are due to robust genetic studies that led to the scientific recognition that although many patients have the same type of cancer their tumors may have harbored different molecular alterations. Personalized therapy and the development of advanced techniques of preclinical imaging and new murine models of disease are emerging concepts that are allowing mapping of disease markers in vivo and in some cases also receptor targeted therapy. Aim of this review is to illustrate some emerging models of disease that allow patient tumor implantation in mice for subsequent drug testing and advanced approaches for therapy mediated by preclinical imaging. In particular we discuss targeted therapy mediated by high frequency ultrasound and magnetic resonance, two emerging techniques in molecular preclinical therapy