Plasticity and learning in a network of coupled phase oscillators

A generalized Kuramoto model of coupled phase oscillators with slowly varying coupling matrix is studied. The dynamics of the coupling coefficients is driven by the phase difference of pairs of oscillators in such a way that the coupling strengthens for synchronized oscillators and weakens for non-synchronized pairs. The system possesses a family of stable solutions corresponding to synchronized clusters of different sizes. A particular cluster can be formed by applying external driving at a given frequency to a group of oscillators. Once established, the synchronized state is robust against noise and small variations in natural frequencies. The phase differences between oscillators within the synchronized cluster can be used for information storage and retrieval.Comment: 10 page

Synchronization in a System of Globally Coupled Oscillators with Time Delay

We study the synchronization phenomena in a system of globally coupled oscillators with time delay in the coupling. The self-consistency equations for the order parameter are derived, which depend explicitly on the amount of delay. Analysis of these equations reveals that the system in general exhibits discontinuous transitions in addition to the usual continuous transition, between the incoherent state and a multitude of coherent states with different synchronization frequencies. In particular, the phase diagram is obtained on the plane of the coupling strength and the delay time, and ubiquity of multistability as well as suppression of the synchronization frequency is manifested. Numerical simulations are also performed to give consistent results

Regulation of ciliated cell differentiation in cultures of rat tracheal epithelial cells.

The cellular pathway of ciliated cell differentiation and its regulation is poorly defined. To begin to understand the process of ciliated cell differentiation, we sought to identify factors regulating ciliated cell development in vitro. Rat tracheal epithelial (RTE) cells were cultured on collagen gel-coated membranes at an air-liquid interface in hormone- and growth factor-supplemented medium (complete medium [CM]). Under these conditions, RTE cells first proliferate and then differentiate into a pseudostratified mucociliary epithelium. Ciliated cell differentiation was measured using a monoclonal antibody, RTE3, which was shown to specifically react with the plasma membrane of ciliated cells. Cultures were immunostained in situ, and the percentage of the culture surface covered with ciliated cells was estimated using videomicroscopy and an image analysis program. If an air-liquid interface was not created and the cells were maintained in the submerged state, ciliated cell differentiation was suppressed 25-fold. Culture in the absence of mitogenic components present in CM, including epidermal growth factor (EGF), cholera toxin (CT), or bovine pituitary extract, resulted in 2- to 4-fold increases in the percentage of ciliated cells. When both EGF and CT were removed from the media, DNA synthesis and total cell number was reduced, while ciliated cell differentiation increased as much as 5-fold. These results demonstrate that submersion inhibits, while withdrawal of mitogenic compounds promotes, ciliated cell differentiation in vitro

Quantum Coherence in a Single Ion due to strong Excitation of a metastable Transition

We consider pump-probe spectroscopy of a single ion with a highly metastable (probe) clock transition which is monitored by using the quantum jump technique. For a weak clock laser we obtain the well known Autler-Townes splitting. For stronger powers of the clock laser we demonstrate the transition to a new regime. The two regimes are distinguished by the transition of two complex eigenvalues to purely imaginary ones which can be very different in magnitude. The transition is controlled by the power of the clock laser. For pump on resonance we present simple analytical expressions for various linewidths and line positions.Comment: 6 figures. accepted for publication in PR

Collective behavior of "electronic fireflies"

A simple system composed of electronic oscillators capable of emitting and detecting light-pulses is studied. The oscillators are biologically inspired, their behavior is designed for keeping a desired light intensity, W, in the system. From another perspective, the system behaves like modified integrate and fire type neurons that are pulse-coupled with inhibitory type interactions: the firing of one oscillator delays the firing of all the others. Experimental and computational studies reveal that although no driving force favoring synchronization is considered, for a given interval of W phase-locking appears. This weak synchronization is sometimes accompanied by complex dynamical patterns in the flashing sequence of the oscillators.Comment: 4 pages, 4 figures include

Associated production of charged Higgs bosons and top quarks with POWHEG

The associated production of charged Higgs bosons and top quarks at hadron colliders is an important discovery channel to establish the existence of a non-minimal Higgs sector. Here, we present details of a next-to-leading order (NLO) calculation of this process using the Catani-Seymour dipole formalism and describe its implementation in POWHEG, which allows to match NLO calculations to parton showers. Numerical predictions are presented using the PYTHIA parton shower and are compared to those obtained previously at fixed order, to a leading order calculation matched to the PYTHIA parton shower, and to a different NLO calculation matched to the HERWIG parton shower with MC@NLO. We also present numerical predictions and theoretical uncertainties for various Two Higgs Doublet Models at the Tevatron and LHC.Comment: 36 page

Synchronization and resonance in a driven system of coupled oscillators

We study the noise effects in a driven system of globally coupled oscillators, with particular attention to the interplay between driving and noise. The self-consistency equation for the order parameter, which measures the collective synchronization of the system, is derived; it is found that the total order parameter decreases monotonically with noise, indicating overall suppression of synchronization. Still, for large coupling strengths, there exists an optimal noise level at which the periodic (ac) component of the order parameter reaches its maximum. The response of the phase velocity is also examined and found to display resonance behavior.Comment: 17 pages, 3 figure

Phase synchronization and noise-induced resonance in systems of coupled oscillators

We study synchronization and noise-induced resonance phenomena in systems of globally coupled oscillators, each possessing finite inertia. The behavior of the order parameter, which measures collective synchronization of the system, is investigated as the noise level and the coupling strength are varied, and hysteretic behavior is manifested. The power spectrum of the phase velocity is also examined and the quality factor as well as the response function is obtained to reveal noise-induced resonance behavior.Comment: to be published in Phys. Rev.

Meson screening masses from lattice QCD with two light and the strange quark

We present results for screening masses of mesons built from light and strange quarks in the temperature range of approximately between 140 MeV to 800 MeV. The lattice computations were performed with 2+1 dynamical light and strange flavors of improved (p4) staggered fermions along a line of constant physics defined by a pion mass of about 220 MeV and a kaon mass of 500 MeV. The lattices had temporal extents Nt = 4, 6 and 8 and aspect ratios of Ns / Nt \geq 4. At least up to a temperature of 140 MeV the pseudo-scalar screening mass remains almost equal to the corresponding zero temperature pseudo-scalar (pole) mass. At temperatures around 3Tc (Tc being the transition temperature) the continuum extrapolated pseudo-scalar screening mass approaches very close to the free continuum result of 2 \pi T from below. On the other hand, at high temperatures the vector screening mass turns out to be larger than the free continuum value of 2 \pi T. The pseudo-scalar and the vector screening masses do not become degenerate even for a temperature as high as 4Tc. Using these mesonic spatial correlation functions we have also investigated the restoration of chiral symmetry and the effective restoration of the axial symmetry. We have found that the vector and the axial-vector screening correlators become degenerate, indicating chiral symmetry restoration, at a temperature which is consistent with the QCD transition temperature obtained in previous studies. On the other hand, the pseudo-scalar and the scalar screening correlators become degenerate only at temperatures larger than 1.3Tc, indicating that the effective restoration of the axial symmetry takes place at a temperature larger than the QCD transition temperature.Comment: Published versio

Injection site vaccinology of a recombinant vaccinia-based vector reveals diverse innate immune signatures

Poxvirus systems have been extensively used as vaccine vectors. Herein a RNA-Seq analysis of intramuscular injection sites provided detailed insights into host innate immune responses, as well as expression of vector and recombinant immunogen genes, after vaccination with a new multiplication defective, vaccinia-based vector, Sementis Copenhagen Vector. Chikungunya and Zika virus immunogen mRNA and protein expression was associated with necrosing skeletal muscle cells surrounded by mixed cellular infiltrates. The multiple adjuvant signatures at 12 hours post-vaccination were dominated by TLR3, 4 and 9, STING, MAVS, PKR and the inflammasome. Th1 cytokine signatures were dominated by IFNγ, TNF and IL1β, and chemokine signatures by CCL5 and CXCL12. Multiple signatures associated with dendritic cell stimulation were evident. By day seven, vaccine transcripts were absent, and cell death, neutrophil, macrophage and inflammation annotations had abated. No compelling arthritis signatures were identified. Such injection site vaccinology approaches should inform refinements in poxvirus-based vector design.Jessamine E. Hazlewood, Troy Dumenil, Thuy T. Le, Andrii Slonchak, Stephen H. Kazakoff, Ann-Marie Patch ... et al