Certain subclasses of multivalent functions defined by new multiplier transformations

In the present paper the new multiplier transformations \mathrm{{\mathcal{J}% }}_{p}^{\delta }(\lambda ,\mu ,l) (\delta ,l\geq 0,\;\lambda \geq \mu \geq 0;\;p\in \mathrm{% }%\mathbb{N} )} of multivalent functions is defined. Making use of the operator $\mathrm{{\mathcal{J}}}_{p}^{\delta }(\lambda ,\mu ,l),$ two new subclasses $\mathcal{P}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$ and $\widetilde{\mathcal{P}}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$\textbf{\ }of multivalent analytic functions are introduced and investigated in the open unit disk. Some interesting relations and characteristics such as inclusion relationships, neighborhoods, partial sums, some applications of fractional calculus and quasi-convolution properties of functions belonging to each of these subclasses $\mathcal{P}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$ and $\widetilde{\mathcal{P}}_{\lambda ,\mu ,l}^{\delta }(A,B;\sigma ,p)$ are investigated. Relevant connections of the definitions and results presented in this paper with those obtained in several earlier works on the subject are also pointed out

Recovering Joys Law as a Function of Solar Cycle, Hemisphere, and Longitude

Bipolar active regions in both hemispheres tend to be tilted with respect to the East West equator of the Sun in accordance with Joys law that describes the average tilt angle as a function of latitude. Mt. Wilson observatory data from 1917 to 1985 are used to analyze the active-region tilt angle as a function of solar cycle, hemisphere, and longitude, in addition to the more common dependence on latitude. Our main results are as follows: i) We recommend a revision of Joys law toward a weaker dependence on latitude (slope of 0.13 to 0.26) and without forcing the tilt to zero at the Equator. ii) We determine that the hemispheric mean tilt value of active regions varies with each solar cycle, although the noise from a stochastic process dominates and does not allow for a determination of the slope of Joys law on an 11-year time scale. iii) The hemispheric difference in mean tilt angles, 1.1 degrees + 0.27, over Cycles 16 to 21 was significant to a three-sigma level, with average tilt angles in the northern and southern hemispheres of 4.7 degrees + 0.26 and 3.6 degrees + 0.27 respectively. iv) Area-weighted mean tilt angles normalized by latitude for Cycles 15 to 21 anticorrelate with cycle strength for the southern hemisphere and whole-Sun data, confirming previous results by Dasi-Espuig, Solanki, Krivova, et al. (2010, Astron. Astrophys. 518, A7). The northern hemispheric mean tilt angles do not show a dependence on cycle strength. vi) Mean tilt angles do not show a dependence on longitude for any hemisphere or cycle. In addition, the standard deviation of the mean tilt is 29 to 31 degrees for all cycles and hemispheres indicating that the scatter is due to the same consistent process even if the mean tilt angles vary.Comment: 13 pages, 4 figures, 3 table

Incidence, predictors and clinical impact of permanent pacemaker insertion in women following transcatheter aortic valve implantation: insights from a prospective multinational registry

To describe the incidence, predictors, and clinical impact of permanent pacemaker insertion (PPI) following transcatheter aortic valve replacement (TAVR) in women. Background: Data on pacemaker insertion complicating TAVR in women are scarce. Methods: The Women''s International Transcatheter Aortic Valve implantation (WIN-TAVI) is a prospective registry evaluating the safety and efficacy of TAVR in women. We included patients without preprocedural pacemakers and divided them into two groups: (1) PPI and (2) no-PPI. We identified PPI predictors using logistic regression and studied its clinical impact on the Valve Academic Research Consortium (VARC)-2 efficacy and safety endpoints. Results: Out of 1019 patients, 922 were included in the analysis. Post-TAVR PPI occurred in 132 (14.3%) patients. Clinical and procedural characteristics were similar in both groups. Pre-existing right bundle branch block (RBBB) was associated with a high risk of post-TAVR PPI (OR 3.62, 95% CI 1.85–7.06, p < 0.001), while implantation of balloon-expandable prosthesis was associated with a lower risk (OR 0.47, 95% CI 0.30–0.74, p < 0.001). Post-TAVR PPI prolonged in-hospital stay by a median of 2 days (11 [9–16] days in PPI vs. 9 [7–14] days in no-PPI, p = 0.005), yet risks of VARC-2 efficacy and safety endpoints at 1 year were similar in both groups (adjHR 0.95, 95% CI 0.60–1.52, p = 0.84 and adjHR 1.22, 95% CI 0.83–1.79, p = 0.31, respectively). Conclusion: Pacemaker implantation following TAVR is frequent among women and is associated with pre-existing RBBB and valve type. PPI prolongs hospital stay, albeit without any significant impact on 1-year outcomes

The influence of seat backrest angle on perceived discomfort during exposure to vertical whole-body vibration

This article was published in the journal, Ergonomics [© Taylor & Francis Ltd.] and the definitive version is available at: http://dx.doi.org/10.1080/00140139.2012.684889National and International Standards (e.g. BS 6841 and ISO 2631-1) provide methodologies for the measurement and assessment of whole-body vibration in terms of comfort and health. The EU Physical Agents (Vibration) Directive (PAVD) provides criteria by which vibration magnitudes can be assessed. However, these standards only consider upright seated (90°) and recumbent (0°) backrest angles, and do not provide guidance for semi-recumbent postures. This article reports an experimental programme that investigated the effects of backrest angle on comfort during vertical whole-body vibration. The series of experiments showed that a relationship exists between seat backrest angle, whole-body vibration frequency and perceived levels of discomfort. The recumbent position (0°) was the most uncomfortable and the semi-recumbent positions of 67.5° and 45° were the least uncomfortable. A new set of frequency weighting curves are proposed which use the same topology as the existing BS and ISO standards. These curves could be applied to those exposed to whole-body vibration in semi-recumbent postures to augment the existing standardised methods. Practitioner Summary: Current vibration standards provide guidance for assessing exposures for seated, standing and recumbent positions, but not for semi-recumbent postures. This article reports new experimental data systematically investigating the effect of backrest angle on discomfort experienced. It demonstrates that most discomfort is caused in a recumbent posture and that least was caused in a semi-recumbent posture

Effect of microstructure on the stability of retained austenite in transformation-induced-plasticity steels

Two Fe-0.2C-1.55Mn-1.5Si (in wt pet) steels, with and without the addition of 0.039Nb (in wt pet), were studied using laboratory rolling-mill simulations of controlled thermomechanical processing. The microstructures of all samples were characterized by optical metallography, X-ray diffraction (XRD), and transmission electron microscopy (TEM). The microstructural behavior of phases under applied strain was studied using a heat-tinting technique. Despite the similarity in the microstructures of the two steels (equal amounts of polygonal ferrite, carbide-free bainite, and retained austenite), the mechanical properties were different. The mechanical properties of these transformation-induced-plasticity (TRIP) steels depended not only on the individual behavior of all these phases, but also on the interaction between the phases during deformation. The polygonal ferrite and bainite of the C-Mn-Si steel contributed to the elongation more than these phases in the C-Mn-Si-Nb-steel. The stability of retained austenite depends on its location within the microstructure, the morphology of the bainite, and its interaction with other phases during straining. Granular bainite was the bainite morphology that provided the optimum stability of the retained austenite.<br /

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Review of the untapped potentials of antimicrobial materials in the construction sector

Damage caused by microbes results in compromised structural integrity. One key example is that of microbiologically induced concrete corrosion (MICC) due to the bacteria in concrete sewerage pipes which leads to reduced lifespan of sewer pipes. Antimicrobial materials provide a biocidal approach for eradicating the microbes either by inhibiting their growth, or by actively killing them. An ideal antimicrobial material should possess qualities such as sustainability, durability, eco-friendliness, economic viability to avoid the growing issue of antimicrobial resistance (AMR). The literature covering these topics vital to the construction sector is rather scarce. Therefore, this review paper summarises various types of antimicrobial materials currently used in the construction sector detailing their mode of biocidal activity, and their application in structures. This paper also addresses recent developments, and future scope that may aid in employing antimicrobial material in the construction sector, particularly to benefit plumbing and sanitation used in hospitals and high traffic areas and public places including airports, schools, and other educational establishments. Overall, the study draws attention to newer antimicrobial mechanisms and provides recommendations for developing new, efficient antimicrobial materials that can provide sustainability and a safe environment to the construction sector