Multiple familial trichoepithelioma: A case report and review of literature

No Abstract

Relation Between Helicobacter Pylori, Inflammatory (neutrophil) Activity, Chronic Gastritis, Gastric Atrophy And Intestinal Metaplasia

Background: To determine the relation of Helicobacter pylori infection with chronic inflammation, atrophy, activity level and intestinal metaplasia. Patients and Methods: A cross-sectional study of 100 consecutive patients with dyspepsia. These patients were fasted for 12 hours and gastroscopic biopsy specimens were obtained from their gastric mucosae. The specimens were histologically evaluated for H. pylori, inflammatory activity, chronic inflammation, gastric atrophy and intestinal metaplasia. Results: There were 50(50%) females and 50(50%) males. The average ages of women and men were 36.3±11.5 and 42.9±12.8 respectively. Helicobacter pylori was found in 79%. Neutrophil activity was observed in 83%. Inflammation was found in 95%, glandular atrophy in 38%, intestinal metaplasia in 28% of the cases. Incidental (early gastric) cancer was found in 3%, dysplasia in 2% and reactive gastropathy in 7% of the cases. A statistically significant relationship was found between Helicobacter pylori colonization intensity and the degrees of neutrophil activity, chronic inflammation and intestinal metaplasia. Conclusion: We concluded that Helicobacter pylori infection results in neutrophil activation and chronic gastritis, and that it has a role in the development of intestinal metaplasia. The greater the intensity of Helicobacter pylori infection, the greater the degrees of neutrophil activation, chronic gastritis and intestinal metaplasia. Keywords: Helicobacter pylori, Gastritis, atrophy, Intestinal metaplasia, Gastric cancer, Jos Nigerian Journal of Clinical Practice Vol. 11 (3) 2008: pp. 270-27

The Prevalence and Drug Sensitivity of Tuberculosis among Patients Dying in Hospital in KwaZulu-Natal, South Africa: A Postmortem Study

A postmortem study by Ted Cohen and colleagues reveals a huge toll of tuberculosis among patients dying in hospitals in KwaZulu-Natal, South Africa

Descriptive pattern of Benign Salivary Gland Tumours in Jos University Teaching Hospital (JUTH), Jos: A ten-year retrospective study.

Background Salivary gland tumours are common head and neck tumours which account for 2.8 to 10% of all head and neck tumours in most African studies and 8.0 to 10.5 % in most western literature. Benign salivary gland tumours are the commonest form of salivary gland neoplasm, with the ratio of benign to malignant tumours ranging from 1.2:1 to 2:1. Objectives: This study is aimed at describing the histological pattern, age, sex and site distribution of benign salivary gland tumours in Jos University Teaching Hospital from January 1997 to December 2006. Methods: This was a descriptive study of all histotogically confirmed benign salivary gland tumours over a period of ten years. The slides were reported independently by four pathologists. Diagnosis was made and classification done according to the World Health Organization (WHO) classification of salivary gland tumours. Data such as age, sex and site of distribution of these tumours were obtained from the patient's case files. Results: Results show that benign salivary gland tumours had a higher distribution than malignant salivary gland tumours with a ratio of 1.7:1. Of these benign salivary gland tumours, male predominance over females was generally observed. Benign salivary gland tumours occurred more within the age range 4 to 49 years (table 1), with pleomorphic Adenoma accounting for the highest frequency (115) and basal cell adenoma for the lowest frequency (1) [table 2]. Parotid gland was also the commonest site of occurrence of most of these lesions except for basal cell adenoma which was found in the sublingual gland

Patterns of malignant salivary gland tumours in Jos University Teaching Hospital (JUTH), Jos: A ten-year retrospective study

No Abstract

Histopathological Analysis of Breast Cancers in Makurdi, North Central Nigeria

Background: This retrospective study was undertaken to analyse histologically diagnosed breast cancers in the Federal Medical Centre Makurdi which serves not only Benue State but also four neighbouring states of Nassarawa, Kogi, Taraba and Cross-Rivers.Methodology: Archival records of all breast biopsies from January, 1997 to December, 2006 were retrieved and the following data extracted; age, sex, history/clinical features, and histological diagnosis. Where the record of the diagnosis was missing, fresh sections (3-5ì) were obtained from the formalin fixed, paraffin embedded tissue blocks and stained with haematoxylin and eosin. Results were analysed using Epi Info version 3.5.1 and results displayed in tables and figures.Results: Malignant breast lesions constituted 104 (33%) of a total 315 breast biopsies, of which invasive ductal carcinoma was the commonest histological type, 96 (92.3%). The age range of the patients was 17 -75 years with mean age of 44.8 years. The most prevalent age group was 31-50 years which accounted for 70.2% of cases. Features of advanced diseases such as positive axillary lymph nodes, ulceration wide of tumour were seen in 57.6% and 23.O% of cases respectively.Conclusion: This study shows that breast cancer is prevalent in this environment, relatively affecting younger age groups and most of the patients presenting late for evaluation

Hepatocellular carcinoma in Jos, Nigeria

Background: Hepatocellular carcinoma (HCC) is the most common abdominal malignancy, representing 80- 90% of primary liver malignancies around the world. There is a disturbing trend of increased incidence of HCC around the world. We therefore, determined the trend of HCC in Jos. Methods: A ten-year retrospective review was done of all cases of HCC which diagnoses were histologically confirmed as recorded in the Cancer Registry of Jos University Teaching Hospital. The patients\' clinical case notes (including surgical and radiological findings) were also reviewed. Results: A total of 71 cases of HCC (31.3% 0f 227 liver biopsies in the same period) were diagnosed within the 10-year period. There were 46 males and 25 females with a male/female ratio of 1.8:1. The age range of the patients was 23 years to 75 years, with a mean age of 45.4±13.1 years. Seventy two percent (72%) of them were between ages 21 years and 50 years. Only 28% were between 51 years and 80 years. The highest rate of 12(17.1%) was seen in the year 2004. Conclusion: The study showed that there was a high prevalence of HCC in Jos, and that HCC was more prevalent in the younger age group compared to what obtains in developed nations. Keywords: Liver, Hepatocellular carcinoma, age, sex, trend.Nigerian Journal of Medicine Vol. 17 (2) 2008: pp. 211-21

Gastric histopathological findings in mucosal biopsies of symptomatic patients in Jos central Nigeria

No Abstract. Nigerian Journal of Medicine Vol.16 (2) 2007: pp.113-11