A graphic method for depicting basin evolution and changes in the dominant hydrodynamic process from paleocurrent data

Abstract Paleocurrent data measured on depositional elements and sedimentary structures (e.g., channels, cross-strata) are commonly utilized in the description of sedimentary strata. Paleocurrent data provide information about the depositional setting and in some cases can be useful for immediately detecting specific depositional processes (e.g., herringbone cross-strata for bimodal tidal currents). The typical graphical representation used to report paleocurrent data is the rose diagram. However, rose diagrams are not able to disclose all information contained in paleocurrent data, limiting the potentiality of such a representation method. In particular, there is presently no method to highlight changes in the paleogeographic configuration that can ultimately have an impact on the evolution of depositional processes and paleocurrent direction through time. Here, we present a graphic method that permits instant visualization of anomalies in paleocurrent distributions of the stratigraphic record that can be linked to changes in the paleogeography due to tectonic evolution or in the dominant hydrodynamic process. It is important to highlight that the proposed method does not aspire to replace rose diagrams but to provide an additional tool to be used before and in combination with rose diagrams in order to extrapolate as much information as possible from paleocurrent data

Fully Flexible Binding of Taxane-Site Ligands to Tubulin via Enhanced Sampling MD Simulations

Microtubules (MTs) are cytoskeleton components involved in a plenty of cellular functions such as transport, motility, and mitosis. Being polymers made up of α/β-tubulin heterodimers, in order to accomplish these functions, they go through large variations in their spatial arrangement switching between polymerization and depolymerization phases. Because of their role in cellular division, interfering with MTs dynamic behavior has been proven to be suitable for anticancer therapy as tubulin-binding agents induce mitotic arrest and cell death by apoptosis. However, how microtubule-stabilizing agents like taxane-site ligands act to promote microtubule assembly and stabilization is still argument of debate. As in the case of tubulin, traditional docking techniques lack the necessary capabilities of treating protein flexibility that are central to certain binding processes. For this reason, the aim of this project is to put in place a protocol for dynamic docking of taxane-site ligands to β-tubulin by means of enhanced sampling MD simulation techniques. Firstly, the behavior of the binding pocket has been investigated with classical MD simulations. It has been observed that the most flexible part of the taxane site is the so-called “M-loop”, the one involved into the lateral associations of tubulin heterodimers and that is supposed to be stabilized by taxane-site ligands. Secondly, the protocol for the dynamic docking has been put in place using the MD-Binding technique developed by BiKi Technologies. It showed to be effective in reproducing the binding mode of epothilone A and discodermolide as in their X-ray crystal structures. Finally, the protocol has been tested against paclitaxel, a drug for which no X-ray crystal structure is currently available. These results showed the potential of such an approach and strengthen the belief that in the future dynamic docking will replace traditional static docking in the drug discovery and development process

Patients' and caregivers' perspectives: assessing an intensive rehabilitation programme and outcomes in Huntington's disease

Aim: To investigate the subjective evaluation of an intensive rehabilitation programme and outcomes by people with Huntington’s disease (HD) and their caregivers. Subjects and methods: A written questionnaire was mailed to people with mild-moderate HD (n = 40) who had completed at least one course of the intensive, inpatient rehabilitation protocol carried out at a facility of the Italian National Welfare System in the previous 3 years (on average 8.6 months before). Descriptive and inferential statistics were used. Thematic analyses were also conducted on written texts. Results: The response rate was 93%. A general improvement after discharge was perceived by all of the respondents. Improvements were reported on gait, balance, motor control, and fall reduction. Duration of benefits was estimated to last from 1 to 3 months by 71% of informants with no carry over to the next admission, which occurred on average 5.7 months later. Ameliorations were also reported in speech and swallowing, and several psychosocial aspects: mood, apathy, familiar and social relationships (binomial test, p < 0.05). As far as organisational aspects of structure and programme are concerned, all respondents expressed a positive evaluation (binomial test, p < 0.05). The mean vote given to the whole rehabilitation experience by patients on a 10-point scale was 7.3, confirmed by caregivers’ mean vote of 7.4. Additional free comments were added by the majority of respondents (n = 35). From caregivers’ and patient’s perspectives, relevant themes emerged. Conclusion: An intensive rehabilitation programme in people with HD is perceived to produce relevant improvements beyond bodily motor and functional performance. Patients’ and caregivers’ evaluations are relevant in health-care research in order to assess the worth of a programme and to define new ones

A geoarchaeological study of the metaponto coastal belt, southern Italy, based on geomorphological mapping and gis-supported classification of landforms

In this work we tried to infer the settlement rules and archaeological site patterns in pilot coastal area with high “archaeological potential” through the analysis of the spatial relationships between landform unit maps deriving from a GIS-supported procedure of landform extraction integrated with geomorphological analyses and archaeological evidence. This approach has been tested in the coastal Ionian sector of the Basilicata region, where a detailed geoarchaeological research has been carried out in the frame of the multidisciplinary MeTIBas project (the Italian acronyms for Innovative Methods and Technologies for the Cultural Heritages in the Basilicata region), funded by the European Community. The study area extends on the southernmost part of the Bradano Foredeep, southern Italy, and roughly coincides with the Greek settlement territory of Metaponto and its Chora (the area of influence of Greek colonists). Archaeological investigations, regarding about 1400 sites, consisted of a re-examination of literature data and new field surveys. The relationships between landscape elements deriving from the procedure here proposed and archaeological sites have been statistically investigated to derive settlement patterns and rules. Results highlight a preferential distribution of the identified categories of archaeological sites on gently-dipping marine terrace surfaces and near their edges, thus implying that settlement dynamics of the Metaponto territory partially driven by the topographic position

Post-lacustrine evolution of a tectonically-controlled intermontane basin: Drainage network analysis of the Mercure basin, southern Italy

Topographic analysis, drainage network morphometry, river profile analysis, and spatial distribution of fluvio-lacustrine terraces have been used to reconstruct the drainage network evolution in the Mercure River basin, a large intermontane tectonic basin of the axial zone of southern Apennines. Morphotectonic evolution of the study area is mainly controlled by poly-kinematics high-angle WNW-ESE and NE-SW faults, which promoted the development of a complex landscape with relict landscapes and/or low-relief erosional surfaces that occurred in a staircase arrangement at the top of the landscapes or at higher altitudes than the basin infill. The creation of the accommodation space for the deposition of the thick basin infill was related to an important tectonic phase of block-faulting along N120°-trending normal faults, which occurred in the final part of the Lower Pleistocene. Such an evolution strongly controls the longitudinal profile forms of channels draining the northern sector of the study area, which are featured by a well-developed concave-up segment in river profiles of these channels between an upward trait with lower values of channel steepness and the trace of the master fault. River profiles in north-western and south-east sectors of the Mercure River basin exhibit clear knickpoints at altitudes comparable with those of the superimposed orders of relict landscapes related to the initial formation of the tectonic basin and the subsequent evolution of the endorheic basin, with a post-lacustrine geomorphological evolution of the drainage network that is controlled by fluvial incision occurring at rates comparable than those reconstructed by independent morphotectonic markers. The erosion of the threshold of the endorheic basin occurring during the base-level fall of the MIS 12 promoted a dramatic base-level fall of about 150 m, which corresponds to a mean incision rate of about 0.35 mm/yr. Post-lacustrine evolution of the Mercure basin strongly controls the morphometric features of the drainage network, which preserves a centripetal pattern with several planimetric anomalies such as counterflow and high-angle confluences, local-scale fluvial capture phenomena and drainage divide migrations

Sedimentological and morpho-evolution maps of the 'Bosco Pantano di Policoro' coastal system (Gulf of Taranto, southern Italy)

This paper presents the results of a sedimentological study performed to characterize the ‘Bosco Pantano di Policoro e Costa Ionica Foce Sinni’ coastal system, in Basilicata (southern Italy), as part of the PROVIDUNE LIFE Project. The study was focused on the morpho-sedimentological characterization of both the emerged and submerged sectors of the beach system developed along a 3.5 km-long segment of the Ionian coast. A multitemporal comparison of historical aerial photos of the studied coastline concerning the last 100 years was executed. A geomorphological survey was carried out along 36 topographic profiles (each up to 200-m long); these were coupled with bathymetric profiles, reaching a depth of 213 m. Both topographic and bathymetric profiles were measured on three occasions (July, October, December 2010). Textural and compositional analyses of sediments were also performed. The results of this study were synthesized in a series of maps illustrating a schematic geological outline of the study area, a reconstruction of the Sinni river course and shoreline changes from 1908 to 2010 (1:2,400 scale), significant topographic (1:1,300 scale) and bathymetric (1:5,000 scale) profiles, three bathymetric charts (1:31,000 scale) and morpho-sedimentological features of both the coastal and nearshore sectors (1:15,000 scale). This study provides a geological background that is crucial for any intervention planning, as well as for any coastal zone management projects. The results should be also used in order to protect coastal habitats, which is the ultimate goal of the LIFE project

SEMI-AUTOMATIC CLASSIFICATION OF LANDFORMS AS A TOOL TO STRESS GEOARCHAEOLOGICAL ISSUES: AN EXAMPLE FROM THE METAPONTO COASTAL BELT, SOUTHERN ITALY

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long to short term denudation rates in the southern apennines geomorphological markers and chronological constraints

Long- to short-term denudation rates in the southern Apennines: geomorphological markers and chronological constraints Age constraints of geomorphological markers and consequent estimates of long- to short-term denudation rates from southern Italy are given here. Geomorphic analysis of the valley of the Tanagro River combined with apatite fission track data and radiometric dating provided useful information on the ages and evolution of some significant morphotectonic markers such as regional planated landscapes, erosional land surfaces and fluvial terraces. Reconstruction of paleotopography and estimation of the eroded volumes were perfomed starting from the plano-altimetric distribution of several orders of erosional land surfaces surveyed in the study area. Additional data about denudation rates related to the recent and/or active geomorphological system have been obtained by estimating the amount of suspended sediment yield at the outlet of some catchments using empirical relationships based on the hierarchical arrangement of the drainage network. Denudation rates obtained through these methods have been compared with the sedimentation rates calculated for two adjacent basins (the Pantano di San Gregorio and the Vallo di Diano), on the basis of published tephrochronological constraints. These rates have also been compared with those calculated for the historical sediment accumulation in a small catchment located to the north of the study area, with long-term exhumation data from thermochronometry, and with uplift rates from the study area. Long- and short-term denudation rates are included between 0.1 and 0.2 mm/yr, in good agreement with regional data and long-term sedimentation rates from the Vallo di Diano and the Pantano di San Gregorio Magno basins. On the other hand, higher values of exhumation rates from thermochronometry suggest the existence of past erosional processes faster than the recent and present-day exogenic dismantling. Finally, the comparison between uplift and denudation rates indicates that the fluvial erosion did not match the tectonic uplift during the Quaternary in this sector of the chain. The axial zone of the southern Apennines should therefore be regarded as a landscape in conditions of geomorphological disequilibrium

A discrete-time localization method for capsule endoscopy based on on-board magnetic sensing

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