Independent predictors of breast malignancy in screen-detected microcalcifications: biopsy results in 2545 cases

Background: Mammographic microcalcifications are associated with many benign lesions, ductal carcinoma in situ (DCIS) and invasive cancer. Careful assessment criteria are required to minimise benign biopsies while optimising cancer diagnosis. We wished to evaluate the assessment outcomes of microcalcifications biopsied in the setting of population-based breast cancer screening. Methods: Between January 1992 and December 2007, cases biopsied in which microcalcifications were the only imaging abnormality were included. Patient demographics, imaging features and final histology were subjected to statistical analysis to determine independent predictors of malignancy. Results: In all, 2545 lesions, with a mean diameter of 21.8 mm (s.d. 23.8 mm) and observed in patients with a mean age of 57.7 years (s.d. 8.4 years), were included. Using the grading system adopted by the RANZCR, the grade was 3 in 47.7%; 4 in 28.3% and 5 in 24.0%. After assessment, 1220 lesions (47.9%) were malignant (809 DCIS only, 411 DCIS with invasive cancer) and 1325 (52.1%) were non-malignant, including 122 (4.8%) premalignant lesions (lobular carcinoma in situ, atypical lobular hyperplasia and atypical ductal hyperplasia). Only 30.9% of the DCIS was of low grade. Mammographic extent of microcalcifications >15 mm, imaging grade, their pattern of distribution, presence of a palpable mass and detection after the first screening episode showed significant univariate associations with malignancy. On multivariate modeling imaging grade, mammographic extent of microcalcifications >15 mm, palpable mass and screening episode were retained as independent predictors of malignancy. Radiological grade had the largest effect with lesions of grade 4 and 5 being 2.2 and 3.3 times more likely to be malignant, respectively, than grade 3 lesions. Conclusion: The radiological grading scheme used throughout Australia and parts of Europe is validated as a useful system of stratifying microcalcifications into groups with significantly different risks of malignancy. Biopsy assessment of appropriately selected microcalcifications is an effective method of detecting invasive breast cancer and DCIS, particularly of non-low-grade subtypes.G Farshid, T Sullivan, P Downey, P G Gill, and S Pieters

Hybrid Superconductor-Quantum Point Contact Devices using InSb Nanowires

Proposals for studying topological superconductivity and Majorana bound states in nanowires proximity coupled to superconductors require that transport in the nanowire is ballistic. Previous work on hybrid nanowire-superconductor systems has shown evidence for Majorana bound states, but these experiments were also marked by disorder, which disrupts ballistic transport. In this letter, we demonstrate ballistic transport in InSb nanowires interfaced directly with superconducting Al by observing quantized conductance at zero-magnetic field. Additionally, we demonstrate that the nanowire is proximity coupled to the superconducting contacts by observing Andreev reflection. These results are important steps for robustly establishing topological superconductivity in InSb nanowires

Unique Mass Texture for Quarks and Leptons

Texture specific quark mass matrices which are hermitian and hierarchical are examined in detail . In the case of texture 6 zeros matrices, out of sixteen possibilities examined by us, none is able to fit the low energy data (LED), for example, $V_{us} = 0.2196 \pm 0.0023$, $V_{cb} = 0.0395 \pm 0.0017$, $\frac{V_{ub}}{V_{cb}} = 0.08 \pm 0.02$, $V_{td}$ lies in the range $0.004 - 0.013$ (PDG). Similarly none of the 32 texture 5 zeros mass matrices considered is able to reproduce LED. In particular, the latest data from LEP regarding $|V_{ub}|/|V_{cb}|(=0.093\pm0.016)$ rules out all of them. In the texture 4 zeros case, we find that there is a unique texture structure for $U$ and $D$ mass matrices which is able to fit the data.Comment: 12 pages, LaTeX,some changes in the references,minor changes in the text,to appear in Phys Rev D(Rapid communications

Robustness of Planar Fourier Capture Arrays to Colour Changes and Lost Pixels

Planar Fourier capture arrays (PFCAs) are optical sensors built entirely in standard microchip manufacturing flows. PFCAs are composed of ensembles of angle sensitive pixels (ASPs) that each report a single coefficient of the Fourier transform of the far-away scene. Here we characterize the performance of PFCAs under the following three non-optimal conditions. First, we show that PFCAs can operate while sensing light of a wavelength other than the design point. Second, if only a randomly-selected subset of 10% of the ASPs are functional, we can nonetheless reconstruct the entire far-away scene using compressed sensing. Third, if the wavelength of the imaged light is unknown, it can be inferred by demanding self-consistency of the outputs.Comment: 15 pages including cover page, 12 figures, associated with the 9th International Conference on Position Sensitive Detector

Analytic Representation of The Dirac Equation

In this paper we construct an analytical separation (diagonalization) of the full (minimal coupling) Dirac equation into particle and antiparticle components. The diagonalization is analytic in that it is achieved without transforming the wave functions, as is done by the Foldy-Wouthuysen method, and reveals the nonlocal time behavior of the particle-antiparticle relationship. We interpret the zitterbewegung and the result that a velocity measurement (of a Dirac particle) at any instant in time is, as reflections of the fact that the Dirac equation makes a spatially extended particle appear as a point in the present by forcing it to oscillate between the past and future at speed c. From this we infer that, although the form of the Dirac equation serves to make space and time appear on an equal footing mathematically, it is clear that they are still not on an equal footing from a physical point of view. On the other hand, the Foldy-Wouthuysen transformation, which connects the Dirac and square root operator, is unitary. Reflection on these results suggests that a more refined notion (than that of unitary equivalence) may be required for physical systems

Texture Specific Mass Matrices and CP violating asymmetry in B^o_d({\bar B}^o_d) -> \psi K_S

In the context of texture 4 - zero and texture 5 - zero hierarchical quark mass matrices, CP violating asymmetry in $B^o_d({\bar B}^o_d) \to \psi K_S$ (sin2$\beta$) has been evaluated by considering quark masses at $m_Z$ scale. For a particular viable texture 4 - zero mass matrix the range of sin2\beta is: 0.27 - 0.60 and for the corresponding texture 5 - zero case it is 0.31 - 0.59. Further our calculations reveal a crucial dependence of sin2$\beta$ on light quark masses as well as the phase in this sector.Comment: 10 latex pages, 4 EPS figure

The ‘Ombuds Watchers’: Collective Dissent and Legal Protest Among Users of Public Services Ombuds

This article examines the phenomenon of the ‘ombuds watchers’. These are groups of dissatisfied users of public service ombuds schemes who engage in legal protest against the current system of redress for citizen-state complaints. Through the lens of legal consciousness scholarship we propose a framework that conceptualizes the collectivized protest of the ombuds watchers. Based on an empirical dataset, our analysis has shown that the ombuds watchers meet each of the defining characteristics of dissenting collectivism and demonstrates the existence of forms of legal consciousness which present ‘opportunities to build alternative imaginaries and institutions’ (Morgan and Kutch 2015, p. 567). Our case study provides an insight into the potential for dissenting collectives to challenge the hegemonic structures of state law, while at the same time emphasising the continuing power of legal ideology in shaping popular understandings of justice. The article also suggests a pathway for future empirical research into ombuds

Ion-Acoustic Solitons in Bi-Ion Dusty Plasma

The propagation of ion-acoustic solitons in a warm dusty plasma containing two ion species is investigated theoretically. Using an approach based on the Korteveg-de-Vries equation, it is shown that the critical value of the negative ion density that separates the domains of existence of compressi- on and rarefaction solitons depends continuously on the dust density. A modified Korteveg-de Vries equation for the critical density is derived in the higher order of the expansion in the small parameter. It is found that the nonlinear coefficient of this equation is positive for any values of the dust density and the masses of positive and negative ions. For the case where the negative ion density is close to its critical value, a soliton solution is found that takes into account both the quadratic and cubic nonlinearities. The propagation of a solitary wave of arbitrary amplitude is investigated by the quasi-potential method. It is shown that the range of the dust densities around the critical value within which solitary waves with positive and negative potentials can exist simultaneously is relatively wide.Comment: 17 pages, 5 figure

Texture of Yukawa coupling matrices in general two-Higgs-doublet model

We discuss possible parallel textures of the Yukawa coupling matrices in the generaltwo-Higgs-doublet model (2HDM). In those textures the flavor changing neutral currentsare naturally suppressed. Motivated by a phenomenologically successful texturewith four texture zeros in the standard model, we propose a predictive ansatz for the Yukawa coupling matrices with the same texture in the general 2HDM. Compared with the six texture-zero based ansatz proposed by Cheng and Sher, it is in a better agreement with the data of quark mixings and CP violation. The four texture-zero based ansatz predicts a different hierarchy in the Yukawa coupling matrix elements. As a consequence, in the lepton sector, the related Yukawa couplings are less constrained by the experimental upper bound of $\mu\to e\gamma$, which allows significantly larger predictions for other processes. The contributions from neutral scalar interactions to the lepton number violation decay modes $\ell\to \ell_{1}\ell_{2}\ell_{3}$ are calculated in both ansatz. It is shown that the predictions from the four texture-zero based ansatz could be two order of magnitude greater than that from the six texture-zero based one. The branching ratio of $\mu\to 3e$ and $\tau\to 3\mu$ can reach $7.5 \times 10^{-17}$ and 1.3\tiems 10^{-10} respectively. The predicted ratio of $Br(\mu\to 3e)/Br(\tau\to 3e)$ is also larger and almost parameter independent. Those differences make the two ansatz to be easily distinguished by the future experiments.Comment: 12 pages, 2 figure