Trends in knowledge of HIV status and efficiency of HIV testing services in sub-Saharan Africa, 2000-20: a modelling study using survey and HIV testing programme data.

BACKGROUND: Monitoring knowledge of HIV status among people living with HIV is essential for an effective national HIV response. This study estimates progress and gaps in reaching the UNAIDS 2020 target of 90% knowledge of status, and the efficiency of HIV testing services in sub-Saharan Africa, where two thirds of all people living with HIV reside. METHODS: For this modelling study, we used data from 183 population-based surveys (including more than 2·7 million participants) and national HIV testing programme reports (315 country-years) from 40 countries in sub-Saharan Africa as inputs into a mathematical model to examine trends in knowledge of status among people living with HIV, median time from HIV infection to diagnosis, HIV testing positivity, and proportion of new diagnoses among all positive tests, adjusting for retesting. We included data from 2000 to 2019, and projected results to 2020. FINDINGS: Across sub-Saharan Africa, knowledge of status steadily increased from 5·7% (95% credible interval [CrI] 4·6-7·0) in 2000 to 84% (82-86) in 2020. 12 countries and one region, southern Africa, reached the 90% target. In 2020, knowledge of status was lower among men (79%, 95% CrI 76-81) than women (87%, 85-89) across sub-Saharan Africa. People living with HIV aged 15-24 years were the least likely to know their status (65%, 62-69), but the largest gap in terms of absolute numbers was among men aged 35-49 years, with 701 000 (95% CrI 611 000-788 000) remaining undiagnosed. As knowledge of status increased from 2000 to 2020, the median time to diagnosis decreased from 9·6 years (9·1-10) to 2·6 years (1·8-3·5), HIV testing positivity declined from 9·0% (7·7-10) to 2·8% (2·1-3·9), and the proportion of first-time diagnoses among all positive tests dropped from 89% (77-96) to 42% (30-55). INTERPRETATION: On the path towards the next UNAIDS target of 95% diagnostic coverage by 2025, and in a context of declining positivity and yield of first-time diagnoses, disparities in knowledge of status must be addressed. Increasing knowledge of status and treatment coverage among older men could be crucial to reducing HIV incidence among women in sub-Saharan Africa, and by extension, reducing mother-to-child transmission. FUNDING: Steinberg Fund for Interdisciplinary Global Health Research (McGill University); Canadian Institutes of Health Research; Bill & Melinda Gates Foundation; Fonds the recherche du Québec-Santé; UNAIDS; UK Medical Research Council; MRC Centre for Global Infectious Disease Analysis; UK Foreign, Commonwealth & Development Office

Normal zone propagation in various REBCO tape architectures

The normal zone propagation velocity (NZPV) of three families of REBCO tape architectures designed for superconducting fault current limiters and to be used in high voltage direct current transmission systems has been measured experimentally in liquid nitrogen at atmospheric pressure. The measured NZPVs span more than three orders of magnitude depending on the tape architectures. Numerical simulations based on finite elements allow us to reproduce the experiments well. The dynamic current transfer length (CTL) extracted from the numerical simulations was found to be the dominating characteristic length determining the NZPV instead of the thermal diffusion length. We therefore propose a simple analytical model, whose key parameters are the dynamic CTL, the heat capacity and the resistive losses in the metallic layers, to calculate the NZPV.The authors acknowledge the funding of this research by FASTGRID Project (EU-H2020, 721019), the Projects COACHSUPENERGY (MAT2014-51778-C2-1-R), SUMATE (RTI2018-095853-BC21 and RTI2018-095853-B-C22) from the Spanish Ministry of Economy and Competitiveness which were cofunded by the European Regional Development Fund, the Project 2017-SGR 753 from Generalitat de Catalunya and the COST Action NANOCOHYBRI (CA16218). Polytechnique Montréal authors also acknowledge NSERC (Canada), FRQNT (Québec), the RQMP infrastructure and CMC microsystems for financial support. ICMAB authors also acknowledge the Center of Excellence awards Severo Ochoa SEV-2015-0496 and CEX2019-000917-S.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).Peer reviewe

A glycan-based plasmonic sensor for prostate cancer diagnosis

Prostate cancer affects thousands of men who undergo clinical screening tests every year. The main biomarker used for the diagnosis of prostate cancer, prostate specific antigen (PSA), presents limitations that justify investigating new biomarkers to improve reliability. Antibodies against the tumor-associated carbohydrate antigen (Tn), or TACA, develop early in carcinogenesis, making them an interesting alternative as a target for prostate cancer diagnostics. In this work, the Tn antigen was synthesized and immobilized on a surface plasmon resonance sensor coated with a polydopamine/polyethylene oxide mixed layer used both as an anchoring surface for Tn capture moieties and to minimize surface fouling. The sensor could be regenerated and reused at least 60 times without any significant loss in sensitivity. Anti-Tn antibodies were detected in the 0-10 nM concentration range with detection limits of 0.1 and 0.3 nM in spiked buffer solutions and diluted human blood serum samples, respectively. Finally, as a proof-of-concept, this carbohydrate-based sensor was used to successfully discriminate blood serum samples from prostate cancer-free and prostate cancer patients

N 2 O ionization and dissociation dynamics in intense femtosecond laser radiation, probed by systematic pulse length variation from 7 to 500 fs

International audienc

Coulomb imaging of the concerted and stepwise break up processes of OCS ions in intense femtosecond laser radiation

International audienceWe study the break up of OCS in intense femtosecond laser radiation using the FEMPULS technique to vary the laser pulse duration from 7 fs to 200 fs. Newton and Dalitz plots show the progression of molecular deformation and break up for OCS$^{3+}$ and OCS$^{4+}$. For increasing pulse length, the concerted three body dissociation exhibits increasing bending, and the amount of stepwise dissociation decreases. For the longest pulses however the stepwise process increases again. Both phenomena can be interpreted in terms of the effect of the laser field on lower charge states and the behaviour of a wave packet on a saddle point potential. The experiment illustrates the ability of the Coulomb imaging method to track molecular geometry and dynamics and indicates a new path to laser control of molecular parameters