Entrepreneurial Potential of Brazilian Computing Undergraduates At A Mobile App Development Program

Digital entrepreneurship has been one of the chief drivers of world economy.nbsp In this context, the present research is intended to assess the entrepreneurial profile of students who participate in a program for development of mobile apps at Universidade Presbiteriana Mackenzie in Brazil. For such, this research used the Carland scale to measure the entrepreneurial potential of 32 youth from MackMobile project, also considering their choices in defining the project. The results obtained show that, although participants presented good entrepreneurial aptness in personality traits and innovation dimensions, they need to develop entrepreneurial skills for risk propension and strategic posture to become entrepreneurs. The study indicates opportunities for improvement in programs and projects focused on technical qualification in technology programs, complementing them with methodologies turned to the development of personal entrepreneurial competences

Carbodiimide versus Click Chemistry for Nanoparticle Surface Functionalization: A Comparative Study for the Elaboration of Multimodal Superparamagnetic Nanoparticles Targeting αvβ3 Integrins.

International audienceSuperparamagnetic fluorescent nanoparticles targeting αvβ3 integrins were elaborated using two methodologies: carbodiimide coupling and click chemistries (CuACC and thiol-yne). The nanoparticles are first functionalized with hydroxymethylenebisphonates (HMBP) bearing carboxylic acid or alkyne functions. Then, a large number of these reactives functions were used for the covalent coupling of dyes, poly(ethylene glycol) (PEG), and cyclic RGD. Several methods were used to characterize the nanoparticle surface functionalization, and the magnetic properties of these contrast agents were studied using a 1.5 T clinical MRI. The affinity toward integrins was evidenced by solid-phase receptor-binding assay. In addition to their chemoselective natures, click reactions were shown to be far more efficient than the carbodiimide coupling. The grafting increase was shown to enhance targeting affinity to integrin without imparing MRI and fluorescent properties