135 research outputs found
Remote ischaemic preconditioning in the settings of cardiac bypass surgery and coronary angioplasty
Myocardial revascularisation in the form of coronary artery bypass surgery (CABG) and percutaneous coronary interventions (PCI) are the two important treatment strategies in combating ischaemic heart disease. There have been tremendous improvements in many aspects of these revascularisation methods over the years. However both these forms of revascularisation can have a deleterious effect on the myocardium while its vascularity is re-established. This revascularisation induced myocardial injury is one of the prognostically important deleterious effects. Consequently, many therapeutic strategies are being studied which can cardioprotect and reduce peri-operative myocardial injury during CABG and peri-procedural myocardial injury during PCI. We evaluate Remote ischaemic preconditioning, a cardioprotective strategy, for its effect on myocardial revascularisation methods of PCI and CABG. In the PCI settings, the beneficial effect of remote ischaemic preconditioning in patients undergoing elective PCI has now been established. However its role in patients admitted with Non ST elevation acute coronary syndrome (NSEACS) and undergoing urgent PCI is still unknown. This group of patients particularly has increased peri-procedural myocardial injury due to their soft coronary plaque and thrombi. In the CABG settings, remote preconditioning has been shown reduce perioperative myocardial injury in non diabetic patients. There are no clinical studies looking at the beneficial effect of remote preconditioning in diabetic cohort of patients undergoing CABG. In animal models, diabetic myocardium is known to possess higher threshold for preconditioning, albeit still possible to precondition. As diabetic patients, are more vulnerable for myocardial injury during CABG and also tolerate the injury relatively poorly compared to their non diabetic counterparts, it is important to explore for cardioprotective strategies to be applied to this high risk diabetic population. The two clinical studies in this thesis evaluate the effect of remote ischemic preconditioning in a) reducing peri-procedural myocardial injury in patients with NSTEACS undergoing urgent percutaneous intervention and b) reducing peri-operative myocardial injury in type 2 diabetic patients undergoing coronary artery bypass surgery
Vacuum Alignment in SUSY A4 Models
In this note we discuss the vacuum alignment in supersymmetric models with
spontaneously broken flavour symmetries in the presence of soft supersymmetry
(SUSY) breaking terms. We show that the inclusion of soft SUSY breaking terms
can give rise to non-vanishing vacuum expectation values (VEVs) for the
auxiliary components of the flavon fields. These non-zero VEVs can have an
important impact on the phenomenology of this class of models, since they can
induce an additional flavour violating contribution to the sfermion soft mass
matrix of right-left (RL) type. We carry out an explicit computation in a class
of SUSY A4 models predicting tri-bimaximal mixing in the lepton sector. The
flavour symmetry breaking sector is described in terms of flavon and driving
supermultiplets. We find non-vanishing VEVs for the auxiliary components of the
flavon fields and for the scalar components of the driving fields which are of
order m_{SUSY} x and m_{SUSY}, respectively. Thereby, m_{SUSY} is the
generic soft SUSY breaking scale which is expected to be around 1 TeV and
is the VEV of scalar components of the flavon fields. Another effect of these
VEVs can be the generation of a mu term.Comment: 23 pages; added a new section on the relation to Supergravity;
version accepted for publication in JHE
Ultraviolet Completion of Flavour Models
Effective Flavour Models do not address questions related to the nature of
the fundamental renormalisable theory at high energies. We study the
ultraviolet completion of Flavour Models, which in general has the advantage of
improving the predictivity of the effective models. In order to illustrate the
important features we provide minimal completions for two known A4 models. We
discuss the phenomenological implications of the explicit completions, such as
lepton flavour violating contributions that arise through the exchange of
messenger fields.Comment: 18 pages, 8 figure
R-parity violation in SU(5)
We show that judiciously chosen R-parity violating terms in the minimal
renormalizable supersymmetric SU(5) are able to correct all the
phenomenologically wrong mass relations between down quarks and charged
leptons. The model can accommodate neutrino masses as well. One of the most
striking consequences is a large mixing between the electron and the Higgsino.
We show that this can still be in accord with data in some regions of the
parameter space and possibly falsified in future experiments.Comment: 30 pages, 1 figure. Revised version. To appear in JHE
On the nature of the fourth generation neutrino and its implications
We consider the neutrino sector of a Standard Model with four generations.
While the three light neutrinos can obtain their masses from a variety of
mechanisms with or without new neutral fermions, fourth-generation neutrinos
need at least one new relatively light right-handed neutrino. If lepton number
is not conserved this neutrino must have a Majorana mass term whose size
depends on the underlying mechanism for lepton number violation. Majorana
masses for the fourth generation neutrinos induce relative large two-loop
contributions to the light neutrino masses which could be even larger than the
cosmological bounds. This sets strong limits on the mass parameters and mixings
of the fourth generation neutrinos.Comment: To be published. Few typos corrected, references update
Dynamical R-parity Breaking at the LHC
In a class of extensions of the minimal supersymmetric standard model with
(B-L)/left-right symmetry that explains the neutrino masses, breaking R-parity
symmetry is an essential and dynamical requirement for successful gauge
symmetry breaking. Two consequences of these models are: (i) a new kind of
R-parity breaking interaction that protects proton stability but adds new
contributions to neutrinoless double beta decay and (ii) an upper bound on the
extra gauge and parity symmetry breaking scale which is within the large hadron
collider (LHC) energy range. We point out that an important prediction of such
theories is a potentially large mixing between the right-handed charged lepton
() and the superpartner of the right-handed gauge boson (), which leads to a brand new class of R-parity violating interactions of
type and \widetilde{d^c}^\dagger\u^c
e^c. We analyze the relevant constraints on the sparticle mass spectrum and
the LHC signatures for the case with smuon/stau NLSP and gravitino LSP. We note
the "smoking gun" signals for such models to be lepton flavor/number violating
processes: (or ) and
(or ) without
significant missing energy. The predicted multi-lepton final states and the
flavor structure make the model be distinguishable even in the early running of
the LHC.Comment: 30 pages, 13 figures, 6 tables, reference adde
Dark matter scenarios in the minimal SUSY B-L model
We perform a study of the dark matter candidates of a constrained version of
the minimal R-parity-conserving supersymmetric model with a gauged
. It turns out that there are four additional candidates for dark
matter in comparison to the MSSM: two kinds of neutralino, which either
correspond to the gaugino of the or to a fermionic bilepton, as
well as "right-handed" CP-even and -odd sneutrinos. The correct dark matter
relic density of the neutralinos can be obtained due to different mechanisms
including new co-annihilation regions and resonances. The large additional
Yukawa couplings required to break the radiatively often lead to
large annihilation cross sections for the sneutrinos. The correct treatment of
gauge kinetic mixing is crucial to the success of some scenarios. All
candidates are consistent with the exclusion limits of Xenon100.Comment: 45 pages, 22 figures; v2: extended discussion of direct detection
cross section, matches published versio
Single-Scale Natural SUSY
We consider the prospects for natural SUSY models consistent with current
data. Recent constraints make the standard paradigm unnatural so we consider
what could be a minimal extension consistent with what we now know. The most
promising such scenarios extend the MSSM with new tree-level Higgs interactions
that can lift its mass to at least 125 GeV and also allow for flavor-dependent
soft terms so that the third generation squarks are lighter than current bounds
on the first and second generation squarks. We argue that a common feature of
almost all such models is the need for a new scale near 10 TeV, such as a scale
of Higgsing or confinement of a new gauge group. We consider the question
whether such a model can naturally derive from a single mass scale associated
with supersymmetry breaking. Most such models simply postulate new scales,
leaving their proximity to the scale of MSSM soft terms a mystery. This
coincidence problem may be thought of as a mild tuning, analogous to the usual
mu problem. We find that a single mass scale origin is challenging, but suggest
that a more natural origin for such a new dynamical scale is the gravitino
mass, m_{3/2}, in theories where the MSSM soft terms are a loop factor below
m_{3/2}. As an example, we build a variant of the NMSSM where the singlet S is
composite, and the strong dynamics leading to compositeness is triggered by
masses of order m_{3/2} for some fields. Our focus is the Higgs sector, but our
model is compatible with a light stop (with the other generation squarks heavy,
or with R-parity violation or another mechanism to hide them from current
searches). All the interesting low-energy mass scales, including linear terms
for S playing a key role in EWSB, arise dynamically from the single scale
m_{3/2}. However, numerical coefficients from RG effects and wavefunction
factors in an extra dimension complicate the otherwise simple story.Comment: 32 pages, 3 figures; version accepted by JHE
Ventricular Arrhythmia Burden in Patients With Heart Failure and Cardiac Resynchronization Devices: The Importance of Renal Function
Background:
Chronic kidney disease (CKD) is a risk factor for arrhythmias in patients with heart failure (HF). However, the effects of CKD on ventricular arrhythmia (VA) burden in patients with cardiac resynchronization therapy and defibrillator (CRTâD) devices in a primary prevention setting are unknown.
Objective:
To determine whether baseline CKD is associated with increased risk of VA in patients implanted with primary prevention CRTâD devices.
Methods and Results:
In this retrospective study, 199 consecutive primary prevention CRTâD recipients (2005â2010) were stratified by estimated glomerular filtration rate (eGFR) levels prior to device implantation with 106 (53.2%) â„CKD III (eGFR III as the only predictor of sustained VA in this group (adjusted hazard ratio [HR] 2.92, CI = 1.39â6.1, P = 0.004).
Conclusion:
Baseline CKD is a strong independent risk factor for VA in primary prevention CRTâD recipients. Further understanding of the underlying arrhythmogenic mechanisms relating to CKD may be of interest to allow appropriate correction and prevention. Device programming in this cohort may need to reflect this increased risk
The Interplay Between GUT and Flavour Symmetries in a Pati-Salam x S4 Model
Both Grand Unified symmetries and discrete flavour symmetries are appealing
ways to describe apparent structures in the gauge and flavour sectors of the
Standard Model. Both symmetries put constraints on the high energy behaviour of
the theory. This can give rise to unexpected interplay when building models
that possess both symmetries. We investigate on the possibility to combine a
Pati-Salam model with the discrete flavour symmetry that gives rise to
quark-lepton complementarity. Under appropriate assumptions at the GUT scale,
the model reproduces fermion masses and mixings both in the quark and in the
lepton sectors. We show that in particular the Higgs sector and the running
Yukawa couplings are strongly affected by the combined constraints of the Grand
Unified and family symmetries. This in turn reduces the phenomenologically
viable parameter space, with high energy mass scales confined to a small region
and some parameters in the neutrino sector slightly unnatural. In the allowed
regions, we can reproduce the quark masses and the CKM matrix. In the lepton
sector, we reproduce the charged lepton masses, including bottom-tau
unification and the Georgi-Jarlskog relation as well as the two known angles of
the PMNS matrix. The neutrino mass spectrum can present a normal or an inverse
hierarchy, and only allowing the neutrino parameters to spread into a range of
values between and , with .
Finally, our model suggests that the reactor mixing angle is close to its
current experimental bound.Comment: 62 pages, 4 figures; references added, version accepted for
publication in JHE
- âŠ