46 research outputs found
Current knowledge on threatened plant species of French Guiana
The elaboration of
a first list of the most threatened species of the overseas territory of French Guyana was undertaken in 2009
by the Association for Botanical Conservation in French Guiana in collaboration with the National Botanical
Conservatory of Brest. Carried out in synergy with the updating of the species list for Natural Areas of Ecological,
Faunistic and Floritic Interests supervised by the Region Science Council for Natural Heritage, this work
includes 97 vascular plants, 18 of which can be considered as threatened in the state of current knowledge,
according to the IUCN criteria which are recommended by the Federation of National Botanical Conservatories.
Among these 18 taxa, threatened because of their rarity and the fragility of their natural habitats, 17
are already protected by a 2001 ministry decree and one is from a new genus, Hekkingia bordenavei; nine of
these appear to be of high concern for conservation: Cleistes grandiflora (Orchidaceae), Cornutia pubescens
(Verbenaceae), Antirhea triflora (Rubiaceae), Himathantus drasticus (Apocynaceae), Axonopus oiapocensis
(Poaceae), Psychotria granvillei (Rubiaceae), Eriocaulon guyanense (Eriocaulaceae) along with two palm
species subject to National Action Plans for their conservation since 2009, Astrocaryum minus and Bactris
nancibaensis. This study also contributes to the on-going âregional Red Listâ of the French Guiana floraLâĂ©laboration dâune premiĂšre liste des espĂšces de plantes les plus menacĂ©es de Guyane,
dĂ©partement français dâoutre-mer situĂ© en AmĂ©rique du Sud, a Ă©tĂ© entreprise en 2009 par lâAssociation pour
la conservation botanique en Guyane (ACBG) avec lâaide du Conservatoire botanique national de Brest.
Mené de concert avec la réactualisation de la liste des espÚces déterminantes pour les ZNIEFF, coordonnée
par le Conseil scientifique rĂ©gional du patrimoine naturel, ce travail portant sur 97 taxons a abouti Ă
la dĂ©signation dâune premiĂšre liste de 18 espĂšces pouvant ĂȘtre considĂ©rĂ©es comme menacĂ©es en lâĂ©tat des
connaissances et dâaprĂšs les critĂšres de lâUICN, prĂ©conisĂ©s par la fĂ©dĂ©ration des Conservatoires botaniques
nationaux. Parmi ces 18 espÚces considérées comme les plus menacées du fait de la rareté de leurs populations
ou de la vulnĂ©rabilitĂ© de leur habitat restreint, 17 sont protĂ©gĂ©es par lâarrĂȘtĂ© ministĂ©riel de 2001 et une
appartient Ă un genre nouveau, Hekkingia bordenavei. Deux de ces espĂšces font lâobjet depuis 2009 de Plans
nationaux dâaction en faveur de leur conservation. Il sâagit de palmiers particuliĂšrement rares, Astrocaryum
minus et Bactris nancibaensis. Neuf de ces espÚces apparaissent comme prioritaires. Ce travail prépare également
lâĂ©tablissement de la « Liste rouge » rĂ©gionale de la flore de Guyane français
Ligand-Induced Tyrosine Phosphorylation of Cysteinyl Leukotriene Receptor 1 Triggers Internalization and Signaling in Intestinal Epithelial Cells
Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer
Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study
Background Approximately 450â000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings Of 63â093 individuals in the FHSC registry, 11â848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11â476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11â848 individuals. Median age at registry entry was 9·6 years (IQR 5·8â13·2). 10â099 (89·9%) of 11â235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11â848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10â202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10â804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10â428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05â6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50â75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life. Funding Pfizer, Amgen, Merck Sharp & Dohme, SanofiâAventis, Daiichi Sankyo, and Regeneron
Affinamento di un indice per la valutazione della funzionalitĂ dei suoli: lâindice pedoergonico
Affinamento di un indice per la valutazione della funzionalitĂ dei suoli: lâindice pedoergonico
La Pedotecnica nelle strategie di recupero strutturale e culturale della funzionalitĂ del territorio: il paradigma âOrto di San Lorenzoâ.
Small-scale patterns of plant functional types and soil features within Mediterranean temporary ponds.
Temporary ponds (TPs) are shallow water bodies characterized by alternating phases of drought and flooding. They exhibit a small-scale zonation with a central belt (CB), an intermediate belt, and an outer belt (OB). Starting from the hypothesis that plant assemblage composition is affected by the position within TPs, our aims were to define the small-scale patterns of plant functional types, soil evolution, and soil physicochemical properties and to analyze their relationships and how they were affected by pond characteristics (i.e., elevation, substratum, total size, belt size, maximum water depth, and hydroperiod). Our results pointed out that patterns of plant functional types and soil evolution followed the position within the pond, soil physicochemical properties were weakly affected, and there was a relationship between plant functional types, soil small-scale patterns, and pond characteristics. Principal component analysis showed a positive correlation of Alfisols with CB, aquatic and amphibious species, maximum water depth, and hydroperiod, and of Entisols with OB and terrestrial species. A combined microtopography-hydrology effect was the primary factor controlling soil evolution and plant functional type patterns. As a consequence, modification in topographic shape and/or hydrologic parameters could alter TP environments. The results provide information for management strategies as an answer to the concerns surrounding continued worldwide TP declin