Effect of maternal ABO blood type on birth weight and preeclampsia

Background: ABO blood group has been recognized as a risk factor for distinct disease states. The association between ABO blood group and adverse pregnancy outcomes has not been extensively studied, especially in relation to birth weight and preeclampsia (PE). The aim of the present study is to determine whether ABO blood group contributes to the adverse pregnancy outcomes including low birth weight and PE.Methods: Medical data including ABO phenotypes were collected from hospital electronic database and retrospectively reviewed. Adverse pregnancy outcomes included PE and low birth weight. Birth week was also noted for each subject.Results: 2177 charts of mothers who had given birth in our hospital were studied. Overall 605 (27.8%) women had type O blood, 1056 (48.5%) had type A blood, 369 (16.9%) had type B blood and 147 (6.8%) had type AB blood. Pregnant women with type B blood group had significantly lower birth weights compared with type O, A and AB. Birth weeks of all groups were found to be similar with no statistically significant difference. A total of 167 mothers were recorded as having PE. No association was observed between PE and ABO blood groups of study participants.Conclusions: Although maternal ABO phenotype is associated with low birth weight, no association was found between blood type and preeclampsia. We postulate that maternal/fetal immune system genes which are directly associated with ABO blood groups could affect pregnant with a resulting birth weight alterations

The prevelance of human papillomavirus (HPV) genotypes detected by PCR in women with normal and abnormal cervico-vaginal cytology

Objectives: Cervical cancer is the second most common type of cancer for women worldwide with a great proportion proved to be related to human papillomavirus (HPV) infection. As infection with HPV is the strongest risk factor for cervical neoplasia, detection of HPV genotypes in cervical and vaginal specimens of women with normal and abnormal cytology seems to be of paramount importance in cervical cancer screening. The objective of the study is to evaluate the prevalence and HPV genotypes among women with normal or abnormal Pap smear tests. Material and methods: This retrospective study was conducted in a tertiary care university hospital in western Turkey. A total of 201 patients in whom both HPV typing and Pap test was performed between 2012 and 2016 in our obstetrics and gynecology department were enrolled in this study. Clinical and laboratory data were obtained for all participants. Cervical smears of the patients were classified by the Bethesda system and HPV analyses were done using the polymerase chain reaction (PCR) method. Results: This study included 201 women, 72 of whom had normal and 129 of whom had abnormal Pap smear results. HPV DNA was detected in 91 (45.2%) of the 201 investigated women. Out of 72 patients with normal cervico-vaginal cytology, HPV positivity was detected in 35 (49%) patients, whereas 33 (35%) patients out of 94 with ASCUS , 18 (62%) patients out of 29 with LSIL and 5 (83%) patients out of 6 with HSIL had HPV positivity. Out of 35 HPV positive women that had normal pap test results, 25 (75%) were found to have high risk HPV (HR-HPV) genotypes. In women with ASCUS, LSIL and HSIL, HR-HPV genotype rates were found to be 94%, 89% and 100% respectively. The most common identified HPV types were HPV58, HPV16, HPV31, HPV33, HPV11 and HPV35. Conclusions: The frequency of HPV infection was found to be higher in our study compared to previous reports. Moreover, although HR-HPV genotypes were also detected in patients with normal cervical cytology, a majority of patients with HR-HPV genotypes were associated with abnormal cervical smear cytology including high rates of atypical squamous cells of undetermined significance, low-grade squamous intraepithelial lesion, and high-grade squamous intraepithelial lesion

Retrospective ınvestigation of ınpatients with urinary ınfection in an university medical center

Adnan Menderes Üniversitesi Tıp Fakültesi Arastırma ve Uygulama Hastanesi Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Klinigi'nde yatırılarak tedavi edilen üriner sistem infeksiyonlu hastalar geriye dönük olarak incelenerek tanı ve tedavi yaklasımlarınındegerlendirilmesi amaçlandı. Adnan Menderes Üniversitesi Tıp Fakültesi Arastırma ve Uygulama Hastanesi Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Klinigi'nde 01.01.200101.01.2009 tarihleri arasında yatırılarak tedavi edilen 73'ü kadın (%68,2), 34'ü erkek (%31,8) toplam 107 hasta geriye dönük olarak degerlendirildi. Hastalarda en sık rastlanılan belirtiler ates, dizüri ve kostavertebral açı hassasiyeti olarak saptandı. Alınan idrar kültürlerinde %68.2, kan kültürlerinde ise % 35.7 oranında üreme saptandı. Idrar ve kan kültürlerinde en sık üreyen mikroorganizma . Hastaların 79'unda (%74,7) tedaviye empirik olarak, diger hastalara ise (n=27 %25,3) kültür-antibiyogram sonucu ile baslanmıstı. Empirik tedavide birinci seçenek olarak seftriaksonun (n=65, %83) kullanıldıgı tespit edildi. Çalısmamızda tedaviye empirik olarak baslama oranının yüksek oldugu dikkatimizi çekmistir. Bu durumun düzeltilebilmesi için empirik tedavi baslama ölçütlerinin belirlenmesi önemlidir.It was aimed to evaluate the diagnostic and therapeutic approaches to urinary infections by retrospectively investigating the data belonged to inpatients with urinary infection treated in the clinic of Infectious Diseases and Clinical Microbiology ofAdnan Menderes University Medical Center. 107 patients (73 female and 34 male) treated in the Clinic of Infectious Diseases and Clinical Microbiology of Adnan Menderes University Medical Center between 01.01.2001 and 01.01.2009 were retrospectively investigated. The most commonly observed symptoms in the patients were fever, dysuria and costovertebral angle tenderness. Germinal reproduction was detected in the urinary and blood cultures in a ratio of 68.2% and 35.7%, respectively. was the most commonly detected microorganism in the blood and urine cultures. While 74.7 % of the patients (n=79) were treated by empiric antibiotics due to urgency, 25,3 % of the patients were treated based on culture and antibiogram results. Ceftriaxone was the first choice in the empiric treatment (n=65; 83%). We observed that the rate of starting to therapy empirically was higher. That's why it is important to determine the starting criteria of empiric treatment

Post-discharge heart failure monitoring program in Turkey: Hit-PoinT

Objective: The aim of this study was to assess the efficacy and feasibility of an enhanced heart failure (HF) education with a 6-month telephone follow- up program in post-discharge ambulatory HF patients. Methods: The Hit-Point trial was a multicenter, randomized, controlled trial of enhanced HF education with a 6-month telephone follow-up program (EHFP) vs routine care (RC) in patients with HF and reduced ejection fraction. A total of 248 patients from 10 centers in various geographical areas were randomized: 125 to EHFP and 123 to RC. Education included information on adherence to treatment, symptom recognition, diet and fluid intake, weight monitoring, activity and exercise training. Patients were contacted by telephone after 1, 3, and 6 months. The primary study endpoint was cardiovascular death. Results: Although all-cause mortality didn't differ between the EHFP and RC groups (p=NS), the percentage of cardiovascular deaths in the EHFP group was significantly lower than in the RC group at the 6-month follow up (5.6% vs. 8.9%, p=0.04). The median number of emergency room visits was one and the median number of all cause hospitalizations and heart failure hospitalizations were zero. Twenty-tree percent of the EHFP group and 35% of the RC group had more than a median number of emergency room visits (p=0.05). There was no significant difference regarding the median number of all-cause or heart failure hospitalizations. At baseline, 60% of patients in EHFP and 61% in RC were in NYHA Class III or IV, while at the 6-month follow up only 12% in EHFP and 32% in RC were in NYHA Class III or IV (p=0.001). Conclusion: These results demonstrate the potential clinical benefits of an enhanced HF education and follow up program led by a cardiologist in reducing cardiovascular deaths and number of emergency room visits with an improvement in functional capacity at 6 months in post-discharge ambulatory HF patients.Türk Kardiyoloji Derneği Kalp Yetmezliği Çalışma Grub

A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review

Chorioangioma, or hemangioma of the placenta, is the most frequent non-trophoblastic tumor of the placenta consisting of blood vessels and stroma. A great proportion of these tumors are small and well delineated within the placental parenchyma and have no or minimal adverse impact on the fetus. Unfortunately, large tumor size is linked to serious complications such as fetal anemia, hydrops and intrauterine death. This is probably because of arteriovenous shunts leading to progressive heart failure of the fetus. With the increasing rates of antenatal screenings with ultrasonography, prenatal diagnosis of these tumors is widely achieved. Here we report a case of giant placental chorioangioma diagnosed in the second trimester of pregnancy. The size of the tumor minimally increased during follow-up and at term, uncomplicated labor was achieved. Macroscopic and histologic examination confirmed the diagnosis. [Med-Science 2016; 5(4.000): 1037-9

Atrial conduction time, and left atrial mechanical and electromechanical functions in patients with polycystic ovary syndrome: interatrial conduction delay

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women during the reproductive period. Cardiovascular risk factors are more frequent in patients with PCOS. We aimed to investigate the P-wave dispersion (Pd), inter-and intra-atrial conduction time and mechanical functions of the left atrium (LA) in patients with PCOS

Prenatal maternal risk factors for infantile colic

To examine maternal prenatal risk factors for infantile colic (IC). Mothers were asked to complete a standard pre-coded questionnaire form. Inclusion in the study consisted of four criteria. The case group comprised healthy children with infantile colic according to Wessel's definition. The control group comprised healthy children with no history of IC. Prenatal period characteristics of mothers were examined to determine associations with IC. Children with mothers who had prophylactic iron supplementation therapy during pregnancy suffered more from IC. Postpartum depression was found to be more frequent in the case group than in the control group. Gynaecological history, including suffering from migraine, presence of any premenstrual symptoms, dysmenorrhea and high pre-pregnancy body mass index, was associated with development of IC. Pre-gestational gynaecological complaints and pregnancy characteristics may point to IC. These characteristics should be investigated and families should be informed