Aquatic Environmental Contamination: The fate of Asejire Lake in South-Western Nigeria

In Nigeria major cities face serious water pollution crises, in which lack of environmental control of water-dependent activities play an important part. This generates unpleasant implications for health and economic development since most urban and rural areas depend upon lakes and rivers for their water supplies. A study of catfish from Asejire Lake (located at the outskirt of Ibadan, a major city in Oyo State of South-West Nigeria) was carried out to assess the level of contamination due to effluents from various industries in Ibadan, Oyo State particularly the Nigerian Bottling Company, Plc (NBC). The industrial site is located close to the lake and is known to be passing effluent to it. Heavy metals analysis was carried out by the use of an atomic absorption spectrophotometer (AAS) using an airacetylene flame in the Alpha-4 ChemTech spectrophotometer. The result shows that Fe had the highest concentration (11.9 ppm), this was evidenced by an absorption peak at 406 nm and the high level of Fe after its AAS metal determination experiment. The other metals gave the following concentration: Ni (0.9 ppm), Mg (0.47 ppm), Mn (0.45 ppm), Zn (0.35 ppm), Ca (0.06 ppm), Cu and Co (0.00 ppm). These metals had a threshold in which the body can take before they will be lethal, as a result, accumulation and continuous consumption of these aquatics and drinking of the water can lead to coma or death. Fish stocks are at the upper end of the food chains and are vital food supplies to local populations and thus they present a major source of contaminants to local communities. Therefore this project highlights the need for environmental regulation and policy intervention in other to prevent the risk attached to accumulation of these contaminants via the water and the aquatic life. This paper focused on the instruments needed by the policy maker to be better informed and understand how to create a cleaner environment for people so as to increase the economy, health and well being of the people.Key words: Asejire lake, pollution, contamination, catfish

Prevalence and clinical value of IgA and hidden rheumatoid factors in juvenile rheumatoid arthritis

Background: Juvenile rheumatoid arthritis (JRA) is so difficult to be diagnosed early and a small subgroup of patients has positive IgM rheumatoid factor (RF) detected by the standard agglutination techniques.Objective: To investigate the prevalence of IgA and hidden RFs among patients with JRA, to evaluate their diagnostic value in comparison to classic RF and to outline their relation to disease activity, severity as well as to therapy.Methods: The study included 46 patients with JRA (31 females and 15 males). Thirty patients had polyarticular JRA, 9 had oligoarticular JRA and 7 had systemic-onset JRA. Twelve patients had active disease. Thirteen systemic lupus erythematosus patients and 32 healthy subjects were studied as controls. Evaluation was carried out clinically and radiologically (using modified Larsen scoring). Laboratory investigations included CBC, ESR, classic IgM RF (latex agglutination), ANA (indirect  immunofluorescence), IgA-RF (ELISA) and hidden RF seropositivity (ion exchange chromatography).Results: All JRA patients had significantly higher IgA-RF (121.5 ± 195.4 mg/dL) and positivity of hidden RF (56.5%) than lupus (14 ± 6.6 mg/dL and 7.7% respectively) and healthy controls (13.7 ± 6.2 mg/dL and 0% respectively). Classic IgM RF had only 10.9% sensitivity in diagnosing JRA. IgA and hidden RFs had higher sensitivities (50% and 56.5% respectively). Specificity, positive and negative predictive values of IgA-RF were 97.7%, 95.8% and 65.7% and for hidden RF, they were 95.5%, 92.9% and 68.3%. Interestingly, combined positivity of IgA and hidden RFs had 100% specificity and positive predictive value for JRA. Classic RF did not correlate with disease activity and severity in terms of ESR, activity score and Larsen Index. In contrast, patients with active disease had significantly higher value of IgA-RF and positivity of hidden RF than those with quiescent disease. Also, IgA-RF had significant positive correlation with ESR, activity score and Larsen index. Similarly, patients with positive hidden RF had significantly higher values of ESR, activity score and Larsen index than those with negative hidden RF. Steroid therapy was associated with significantly higher level of IgA-RF and positivity of hidden RF, perhaps related to disease severity.Conclusion: IgA and hidden RFs are more sensitive tests in diagnosing JRA than classic IgM RF. Also, the combined positivity of IgA and hidden RFs can confirm the diagnosis of JRA in doubtful cases. The fact that IgA and hidden RFs gave positive results in the meantime that classic RF was negative, together with their significant relation to disease activity and severity highlights their clinical value as reliable laboratory markers of JRA.Key words: juvenile rheumatoid arthritis, rheumatoid factors, IgA-RF, hidden RF, SLE

Sink mechanism for significantly low level of ozone over the Arabian Sea during monsoon

Measurement of surface ozone over the Arabian Sea during the southwest monsoon season (June-September) of 2002 has shown an unusually low level of ozone with an overall average of 9 nmol/mol. Such a low level of ozone could not be explained by simulations using a three-dimensional chemistry transport model, Model for Ozone and Related Tracers (MOZART), which accounts for the known processes of advective transport and includes a standard photochemical mechanism. Thus, for the Arabian Sea region, we propose for the first time that destruction of ozone by reactive halides released from sea salt aerosols is the sink mechanism which played a crucial role in ensuring the significantly low ozone level over the Arabian Sea. Theoretical calculations constrained by observations have shown that, on average, ozone losses due to catalytic action of halogens and due to photolysis plus chemical reaction amount to 2.15 nmol mol-1d-1 and 4.64 nmol mol-1d-1, respectively

Characteristics of aerosols at traffic junctions in Pune city

Vehicular emissions are one of the potential sources of air pollution in the urban regions. Pune, one of the rapidly growing cities of India, faces the severe threat from this problem. Observations of total suspended particulates and Aitken nuclei were conducted at 4 traffic junctions in Pune city during summer (May 2000) and winter (Jan-Feb. 2001). Concentrations of TSP crossed the CPCB limit, recommended for commercial zone, at all the traffic junctions and also the number density of Aitken nuclei was very high. However, aerosols were alkaline in nature, in spite of high concentrations of SO4 and NO3, mainly due to the neutralizing effect of Ca, NH4, Na, Mg and K

Invasive weed optimization algorithm optimized fuzzy logic scaling parameters in controlling a lower limb exoskeleton

© 2016 IEEE. This paper describes a new modified versions of invasive weed optimization algorithm with exponential seeds-spread factor. The modified invasive weed optimization algorithm (MIWO) is employed to optimize the fuzzy input-output scaling factors of lower limb exoskeleton. A fuzzy logic control (FLC) system with the (MIWO) are evolved for reference tracking control. The exoskeleton is developed to enhance and upgrade the lower limb capability and augment the torque of knee and hip of elderly people during the walking cycle. Invasive weed optimization is a bio-inspired search algorithm that mimics how weeds colonize a certain area in nature. The algorithm is modified by applying local knowledge during distribution of seeds that depends on their cost function value in each generation to narrow the accuracy and improve the local search ability. The obtained results from the modified invasive weed optimization algorithm are compared with heuristic gain values to improve the performance of the exoskeleton system. The Visual Nastran 4D software is used to develop a simulation model of the humanoid and an exoskeleton for testing and verification of the developed control mechanism. Simulation results demonstrating the performance of the adopted approach are presented and discussed

Effectiveness of counseling for anxiety and depression in mothers of children ages 0-30 months by community workers in Karachi, Pakistan: a quasi experimental study

<p>Abstract</p> <p>Background</p> <p>The prevalence of anxiety/depression is quite high during the perinatal period but unfortunately its detection and treatment have been less than satisfactory. Moreover, many women are reluctant to take pharmacotherapy for fear of excretion of drugs into their breast milk. This study assesses the effectiveness of counseling from minimally trained community health workers in reducing anxiety/depression, the rate of recurrence and the interval preceding recurrence in women during first two and a half years after childbirth.</p> <p>Methods</p> <p>In a quasi-experimental study, community women from two under-privileged communities were trained in data gathering, teaching healthy child-rearing practices, basic counseling skills, and screening for anxiety/depression by using an indigenously developed questionnaire, the Aga Khan University Anxiety and Depression Scale (AKUADS). The diagnosis was further confirmed by a clinical psychologist using DSM IV criteria. After obtaining consent, 420 women were screened and 102 were identified as having anxiety/depression. Screening was carried out after 1, 2, 6, 12, 18, 24 and 30 months of a live birth. Only 62 out of 102 agreed to be counseled and received eight weekly sessions. AKUADS was re-administered at 4 weeks and 8 weeks after the beginning of counseling; this was followed by the clinical psychologist's interview for confirmation of response. After recovery, screening was continued every 3 months for detection of recurrence throughout the study period. Out of the women who had declined counseling 12 agreed to retake AKUADS after 4 and 8 weeks of diagnosis. Independent samples t-test, chi-square test, Repeated Measures ANOVA and Kaplan Meier technique were used for the analysis.</p> <p>Results</p> <p>A significant decline in level of anxiety/depression was found in both the counseled and the non-counseled groups at 4 and 8 weeks (p-value < 0.001) but the counseled group fared better than the non-counseled for recovery, reduction in the rate of recurrence and increase in the duration before relapse.</p> <p>Conclusions</p> <p>As our results cannot be generalized; further studies need to be carried out, to assess the benefit of incorporating minimal counseling skills in the training of community health workers.</p

Juvenile Batten disease (CLN3): Detailed Ocular Phenotype, Novel Observations, Delayed Diagnosis, Masquerades, and Prospects for Therapy

PURPOSE To characterize the retinal phenotype of juvenile neuronal ceroid lipofuscinosis (JNCL), highlight delayed and mistaken diagnosis, and propose an algorithm for early identification. DESIGN Retrospective case series. SUBJECTS Eight children (5 females) with JNCL. METHODS Review of clinical notes, retinal imaging including fundus autofluorescence (FAF) and optical coherence tomography (OCT), electroretinography (ERG), and both microscopy and molecular genetic testing. MAIN OUTCOME MEASUREMENTS Demographic data, signs and symptoms, visual acuity, FAF and OCT findings, ERG phenotype, and microscopy/molecular genetics. RESULTS Subjects presented with rapid bilateral vision loss over one to eighteen months, with mean visual acuity deteriorating from 0.44 LogMAR (range: 0.20 - 1.78 LogMAR) at baseline, to 1.34 LogMAR (0.30 LogMAR - light perception) at last follow-up. Age of onset ranged from 3 to 7 years (mean 5.3 years). The age at diagnosis of JNCL ranged from 7 to 10 years (mean 8.3 years). Six children displayed eccentric fixation, and six had cognitive or neurological signs at time of diagnosis (75%). Seven patients had bilateral bull’s-eye maculopathy at presentation. Coats-like exudative vasculopathy, not previously reported in JNCL, was observed in one patient. OCT imaging revealed near complete loss of outer retinal layers, and marked atrophy of the nerve fibre and ganglion cell layers, at the central macula. An ‘electronegative’ ERG was present in four patients (50%), but with additional a-wave reduction; there was an undetectable ERG in the remaining four. Blood film microscopy revealed vacuolated lymphocytes and electron microscopy showed lysosomal (fingerprint) inclusions, in all eight patients. CONCLUSIONS In a young child with bilateral rapidly progressive vision loss and macular disturbance, blood film microscopy to detect vacuolated lymphocytes is a rapid, readily accessible, and sensitive screening test for JNCL. Early suspicion of JNCL can be aided by detailed directed history and high-resolution retinal imaging, with subsequent targeted microscopy/genetic testing. Early diagnosis is critical to ensure appropriate management, counselling, support and social care for children and their families. Furthermore, although potential therapies for this group of disorders are in early phase clinical trial, realistic expectations are that successful intervention will be most effective when initiated at the earliest stage of disease

Studies of trace gases and Aitken Nuclei at inland and coastal stations - A part of INDOEX programme

As a part of the Indian Ocean Experiment (INDOEX) programme, ground-based measurements of trace gases (SO2, NO2, NH3 and O3) and Aitken Nuclei (AN) were carried out at Pune during March-April 1998. Also, measurements of surface ozone and AN were made during 5-10 January 1998, the inter comparison campaign of various instruments at Thiruvananthapuram. The mean concentrations of SO2, NO2, NH3 and O3 at Pune were 3.75, 5.81, 3.21 and 57.8 μg/m3 respectively and that of O3 at Thiruvananthapuram was 44 μg/m3. The average concentration of AN was about five times higher at Pune (19,000/cm3) than that at Thiruvananthapuram (4,400/cm3), indicating more pollution at Pune than at Thiruvananthapuram. The diurnal variation of surface ozone showed high concentrations during the day and low concentrations during the night at both the locations. Diurnal variation of AN at Pune showed a daytime maximum and a night-time minimum. Whereas, at Thiruvananthapuram night-time values were higher than the daytime values which can be attributed to the influence of the land and sea breeze

Atmospheric aerosol characteristic studies at Pune and Thiruvananthapuram during INDOEX programme - 1998

Total suspended particulates (TSP) and mass size distribution of aerosols were monitored by using a high-volume air sampler and a low-volume 9-stage Anderson sampler, respectively during March-April 1998 at Pune and during 5-9 January 1998 at Thiruvananthapuram. All these samples were extracted for water-and acid-soluble components using the standard extraction method. The water-soluble extracts were analysed for Cl, SO4, NO3, NH4, Na, K, Ca and Mg and acid-soluble extracts for Al, Fe, Mn, Cu, Zn, Pb, Cd, Ni and Sb. The concentration of TSP varied from 67 to 185 μg/m3 with an average of 122 μg/m3 at Pune and from 35 to 73 μg/m3 with an average of 57 μg/m3 at Thiruvananthapuram. The mass size distribution of aerosols showed bimodal distribution having one peak in coarse mode and the other in fine mode at both the locations. The results of the study are presented here

Early and total yield enhancement of the globe artichoke using an ecofriendly seaweed extract-based biostimulant and PK fertilizer

This is the final version. Available from MDPI via the DOI in this record.This study evaluated the effect of phosphorus and potassium (PK) fertilizer levels and foliar seaweed extract on early and total yield productivity and the growth of globe artichoke plants. Field experiments were conducted over two seasons on loamy–clay soil at the vegetable research farm, of the Faculty of Agriculture, Alexandria University, Egypt. Fertilizer levels of 0, 25, 50 and 75 mL L−1, and seaweed extract concentrations of 0, 5 and 10 mg L−1, individually and in combination, were used. Globe artichoke plants treated with PK liquid fertilizer, with and without seaweed extract, showed critical increases in growth (plant height and number of leaves per plant as well as foliage dry weight), yield, and some chemical constituents compared to untreated plants. The PK3 fertilizer level and 10 mL L−1 seaweed extract as a foliar spray showed greater effects than other combinations.King Saud University Researchers Supporting Projec