Nocturnal blood pressure in untreated essential hypertensives.

Aim. Prevalence, correlates and reproducibility of nocturnal hypertension (NH) as defined by fixed cut-off limits in uncomplicated essential hypertension are poorly defined. Therefore, we assessed such issue in a cohort of 658 untreated hypertensives. Methods. All subjects underwent procedures including cardiac and carotid ultrasonography, 24-h urine collection for microalbuminuria, ambulatory blood pressure monitoring (ABPM), over two 24-h periods within 4 weeks. NH was defined according to current guidelines (i.e. night-time blood pressure, BP 65 120/70 mmHg) and non-dipping status as a reduction in average systolic (SBP) and diastolic BP (DBP) at night lower than 10% compared with daytime values. Results. A total of 477 subjects showed NH during the first and second ABPM period; 62 subjects had normal nocturnal BP (NN) in both ABPM sessions. Finally, 119 subjects changed their pattern from one ABPM session to the other. Overall, 72.5% of subjects had reproducible NH, 18% variable pattern (VP) and 9.5% reproducible NN. In the same group, figures of reproducible non-dipping, variable dipping and reproducible dipping pattern were 24%, 24% and 52%, respectively. Among NH patients, 56% of whom were dippers, subclinical cardiac organ damage was more pronounced than in their NN counterparts. Conclusions. In uncomplicated essential hypertensives, NH is a more frequent pattern than non-dipping; NH is associated with organ damage, independently of dipping/non-dipping status. This suggests that options aimed at restoring a blunted nocturnal BP fall may be insufficient to prevent cardiovascular complications unless night-time BP values are fully normalize

Left ventricular hypertrophy and abdominal aorta size in essential hypertension

AIM: To investigate the association between subclinical organ damage and abdominal aortic diameter in a large cohort of uncomplicated essential hypertensive patients. Methods: Subclinical markers of organ damage (i.e. left ventricular mass, carotid intima-media thickness and plaques, microalbuminuria and retinal changes) and abdominal aortic diameter (ultrasonography) were assessed in 2430 (mean age 53 \ub1 13 years) untreated and treated hypertensive patients included in the Evaluation of Target Organ Damage in Hypertension (ETODH) study. Results: In the whole study population, left ventricular mass index was the most important correlate (\u3b2 = 0.418, P < 0.0001) of the absolute abdominal aortic diameter and, after age, (\u3b2 = 0.268, P < 0.0001) of abdominal aortic diameter indexed to body surface area (abdominal aorta index, AAI). In a sex-based analysis, a stepwise increase in left ventricular mass index as well as in prevalence of left ventricular hypertrophy (LVH), carotid intima-media thickness and plaques occurred from the lower to the upper quartile of AAI in men, but not in women. No correlations were found between AAI and microalbuminuria or retinal changes. Conclusion: Our findings support a sex-specific relation between abdominal aorta size and subclinical organ damage by showing that LVH in hypertensive men is an independent correlate for enlarged abdominal aorta. On the basis of these data, diagnostic protocols for detecting subclinical alterations in the abdominal aorta should be optimized