31 research outputs found
A TRP channel that senses cold stimuli and menthol
AbstractA distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here we describe the cloning and characterization of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neurons. Cells overexpressing the TRPM8 channel can be activated by cold temperatures and by a cooling agent, menthol. Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with preâBâcell acute lymphoblastic leukaemia
First published: 23 February 2021Disease relapse is the greatest cause of treatment failure in paediatric Bâcell acute lymphoblastic leukaemia (BâALL). Current risk stratifications fail to capture all patients at risk of relapse. Herein, we used a machineâlearning approach to identify BâALL blastâsecreted factors that are associated with poor survival outcomes. Using this approach, we identified a twoâgene expression signature (CKLF and IL1B) that allowed identification of highârisk patients at diagnosis. This twoâgene expression signature enhances the predictive value of current at diagnosis or endâofâinduction risk stratification suggesting the model can be applied continuously to help guide implementation of riskâadapted therapies.Stephen Fitter, Alanah L. Bradey, Chung Hoow Kok, Jacqueline E. Noll, Vicki J. Wilczek, Nicola C. Venn ... et al