151 research outputs found
Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality. We have been studying the D6 chemokine scavenging receptor, which played an indispensable role in the resolution phase of inflammatory responses and does so by facilitating removal of inflammatory CC chemokines. In D6-deficient mice, otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasis. In the present study, we have used transcriptomic approaches to define the molecular make up of this response. The data presented highlight potential roles for a number of cytokines in initiating and maintaining the psoriasis-like pathology. Most compellingly, we provide data indicating a key role for the type I interferon pathway in the emergence of this pathology. Neutralizing antibodies to type I interferons are able to ameliorate the psoriasis-like pathology, confirming a role in its development. Comparison of transcriptional data generated from this mouse model with equivalent data obtained from human psoriasis further demonstrates the strong similarities between the experimental and clinical systems. As such, the transcriptional data obtained in this preclinical model provide insights into the cytokine network active in exaggerated inflammatory responses and offer an excellent tool to evaluate the efficacy of compounds designed to therapeutically interfere with inflammatory processes
Heavy Residue Formation in 20 MeV/nucleon 197Au + 90Zr collisions
The yields and velocity distributions of heavy residues and fission fragments
from the reaction of 20 MeV/nucleon 197Au + 90Zr have been measured using the
MSU A1200 fragment separator. A bimodal distribution of residues is observed,
with one group, resulting from peripheral collisions, having fragment mass
numbers A=160-200, while the other group, resulting from ``hard'' collisions,
has A=120-160. This latter group of residues can be distinguished from fission
fragments by their lower velocities. A model combining deep-inelastic transfer
and incomplete fusion for the primary interaction stage and a statistical
evaporation code for the deexcitation stage has been used to describe the
properties of the product distributions.Comment: 19 pages, 6 figures, preprint submitted to Nucl. Phys.
Active Galaxies in the UV
In this article we present different aspects of AGN studies demonstrating the
importance of the UV spectral range. Most important diagnostic lines for
studying the general physical conditions as well as the metalicities in the
central broad line region in AGN are emitted in the UV. The UV/FUV continuum in
AGN excites not only the emission lines in the immediate surrounding but it is
responsible for the ionization of the intergalactic medium in the early stages
of the universe. Variability studies of the emission line profiles of AGN in
the UV give us information on the structure and kinematics of the immediate
surrounding of the central supermassive black hole as well as on its mass
itself.Comment: 29 pages, 13 figures, Ap&SS in pres
A developmental analysis of communication between mothers and infants with Down's syndrome
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68850/2/10.1177_027112148300300110.pd
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
Supermassive Binaries and Extragalactic Jets
Some quasars show Doppler shifted broad emission line peaks. I give new
statistics of the occurrence of these peaks and show that, while the most
spectacular cases are in quasars with strong radio jets inclined to the line of
sight, they are also almost as common in radio-quiet quasars. Theories of the
origin of the peaks are reviewed and it is argued that the displaced peaks are
most likely produced by the supermassive binary model. The separations of the
peaks in the 3C 390.3-type objects are consistent with orientation-dependent
"unified models" of quasar activity. If the supermassive binary model is
correct, all members of "the jet set" (astrophysical objects showing jets)
could be binaries.Comment: 31 pages, PostScript, missing figure is in ApJ 464, L105 (see
http://www.aas.org/ApJ/v464n2/5736/5736.html
The Seyfert-LINER Galaxy NGC 7213: An XMM-Newton Observation
We examine the XMM X-ray spectrum of the LINER-AGN NGC 7213, which is best
fit with a power law, K-alpha emission lines from Fe I, Fe XXV and Fe XXVI and
a soft X-ray collisionally ionised thermal plasma with kT=0.18 +0.03/-0.01 keV.
We find a luminosity of 7x10^(-4) L_Edd, and a lack of soft X-ray excess
emission, suggesting a truncated accretion disc. NGC 7213 has intermediate
X-ray spectral properties, between those of the weak AGN found in the LINER M81
and higher luminosity Seyfert galaxies. This supports the notion of a
continuous sequence of X-ray properties from the Galactic Centre through LINER
galaxies to Seyferts, likely determined by the amount of material available for
accretion in the central regions.Comment: 7 pages, 2 figures. To appear in From X-ray Binaries to Quasars:
Black Hole Accretion on All Mass Scales, ed. T. J. Maccarone, R. P. Fender,
and L. C. Ho (Dordrecht: Kluwer
Combining Techniques to Reveal Emergent Effects in Infants' Segmentation, Word Learning, and Grammar
Towards evidence-based marketing: The case of childhood obesity
Contentious commodities such as tobacco, alcohol and fatty foods are bringing marketing under scrutiny from consumers and policymakers. Yet there is little agreement on whether marketing is harmful to society. Systematic review (SR), a methodology derived from clinical medicine, offers marketers a tool for providing resolution and allowing policymakers to proceed with greater confidence. This article describes how SR methods were applied for the first time to a marketing problem -- the effects of food promotion to children. The review withstood scrutiny and its findings were formally ratified by government bodies and policymakers, demonstrating that SR methods can transfer from clinical research to marketing
Hierarchy of Scales in Language Dynamics
Methods and insights from statistical physics are finding an increasing variety of applications where one seeks to understand the emergent properties of a complex interacting system. One such area concerns the dynamics of language at a variety of levels of description, from the behaviour of individual agents learning simple artificial languages from each other, up to changes in the structure of languages shared by large groups of speakers over historical timescales. In this Colloquium, we survey a hierarchy of scales at which language and linguistic behaviour can be described, along with the main progress in understanding that has been made at each of them − much of which has come from the statistical physics community. We argue that future developments may arise by linking the different levels of the hierarchy together in a more coherent fashion, in particular where this allows more effective use of rich empirical data sets
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