Negotiating a turnkey system: The vendor's viewpoint

My talk today will be from the viewpoint of a business manager responsible for product development, product marketing and product service, while at the same time meeting established goals for profitability. It is not my intention to give a highly technical or legalistic presentation. First, I am not qualified to do so, and second, you are more likely to benefit from understanding the general concepts involved in contracting and leaving the legal details to counsel.published or submitted for publicatio

Superhard Phases of Simple Substances and Binary Compounds of the B-C-N-O System: from Diamond to the Latest Results (a Review)

The basic known and hypothetic one- and two-element phases of the B-C-N-O system (both superhard phases having diamond and boron structures and precursors to synthesize them) are described. The attention has been given to the structure, basic mechanical properties, and methods to identify and characterize the materials. For some phases that have been recently described in the literature the synthesis conditions at high pressures and temperatures are indicated.Comment: Review on superhard B-C-N-O phase

Cultured fish cells metabolize octadecapentaenoic acid (all-cis delta3,6,9,12,15–18∶5) to octadecatetraenoic acid (all-cis delta6,9,12,15–18∶4) via its 2-trans intermediate (trans delta2, all-cis delta6,9,12,15–18∶5)

Octadecapentaenoic acid (all-cis Δ3,6,9,12,15-18:5; 18:5n-3) is an unusual fatty acid found in marine dinophytes, haptophytes and prasinophytes. It is not present at higher trophic levels in the marine food web but its metabolism by animals ingesting algae is unknown. Here we studied the metabolism of 18:5n-3 in cell lines derived from turbot (Scophthalmus maximus), gilthead sea bream (Sparus aurata) and Atlantic salmon (Salmo salar). Cells were incubated in the presence of approximately 1 μM [U-14C] 18:5n-3 methyl ester or [U-14C] 18:4n-3 (octadecatetraenoic acid; all-cis Δ6,9,12,15-18:4) methyl ester, both derived from the alga Isochrysis galbana grown in H14CO3, and also with 25 μM unlabelled 18:5n-3 or 18:4n-3. Cells were also incubated with 25 μM trans Δ2, all-cis Δ6,9,12,15-18:5 (2-trans 18:5n-3) produced by alkaline isomerization of 18:5n-3 chemically synthesized from docosahexaenoic acid (all-cis Δ4,7,10,13,16,19-22:6; 22:6n-3). Radio- and mass analyses of total fatty acids extracted from cells incubated with 18:5n-3 were consistent with this fatty acid being rapidly metabolized to 18:4n-3 which was then elongated and further desaturated to eicosatetraenoic acid (all-cis Δ8,11,14,17,19-20:4; 20:4n-3) and eicosapentaenoic acid (all-cis Δ5,8,11,14,17-20:5; 20:5n-3). Similar mass increases of 18:4n-3 and its elongation and further desaturation products occurred in cells incubated with 18:5n-3 or 2-trans 18:5n-3. We conclude that 18:5n-3 is readily converted biochemically to 18:4n-3 via a 2-trans 18:5n-3 intermediate generated by a Δ3,Δ2-enoyl-CoA-isomerase acting on 18:5n-3. Thus, 2-trans 18:5n-3 is implicated as a common intermediate in the β-oxidation of both 18:5n-3 and 18:4n-3

Een procedureel rechtvaardiger arbitragesysteem als remedie tegen kwetsende spreekkoren in voetbalstadions.

In dit experiment stond de relatie tussen rechtvaardigheid en verbale agressie jegens voetbalscheidsrechters centraal. De respondenten (N = 48 mannen; allen in meer of' mindere mate supporter van SC Heerenveen) kregen een digitaal videofragment uit een wedstrijd van SC Heerenveen te zien waarbij sprake was van een voor SC Heerenveen nadelige beslissing die correct (distributieve rechtvaardigheid) of incorrect (distributieve onrechtvaardigheid) was. Het effect van distributieve (on)rechtvaardigheid op verbale agressie werd onder drie verschillende condities van procedurele rechtvaardigheid onderzocht: het thans vigerende arbitragesysteen, het thans vigerende arbitragesysteem met een herhaling, en een nieuw, procedureel rechtvaardiger arbitragesysteem waarin de scheidsrechter gebruik maakte van videobeelden voordat hij een definitieve beslissing nam. Overeenkomistig de verwachtingen lieten de resultaten zien dat in het huidige systeem, een correcte maar voor SC Heerenveen nadelige arbitrale beslissing relatief veel verbale agressie opriep, maar alleen bij toeschouwers die zich sterk identificeerden met SC Heerenveen. Dit resultaat suggereert dat verbale agressie in voetbalstadions kan worden beteugeld door invoering van het nieuwe, procedureel rechtvaardiger arbitragesysteem