Hydroxyapatite for biomedical applications: A short overview

Calcium phosphates (CaPs) are biocompatible and biodegradable materials showing a great promise in bone regeneration as good alternative to the use of auto-and allografts to guide and support tissue regeneration in critically-sized bone defects. This can be certainly attributed to their similarity to the mineral phase of natural bone. Among CaPs, hydroxyapatite (HA) deserves a special attention as it, actually is the main inorganic component of bone tissue. This review offers a comprehensive overview of past and current trends in the use of HA as grafting material, with a focus on manufacturing strategies and their effect on the mechanical properties of the final products. Recent advances in materials processing allowed the production of HA-based grafts in different forms, thus meeting the requirements for a range of clinical applications and achieving enthusiastic results both in vitro and in vivo. Furthermore, the growing interest in the optimization of three-dimensional (3D) porous grafts, mimicking the trabecular architecture of human bone, has opened up new challenges in the development of bone-like scaffolds showing suitable mechanical performances for potential use in load bearing anatomical sites

Sintering behavior of a six-oxide silicate bioactive glass for scaffold manufacturing

The intrinsic brittleness of bioactive glasses (BGs) is one of the main barriers to the widespread use of three-dimensional porous BG-derived bone grafts (scaffolds) in clinical practice. Among all the available strategies for improving the mechanical properties of BG-based scaffolds, strut densification upon sintering treatments at high temperatures represents a relatively easy approach, but its implementation might lead to undesired and poorly predictable decrease in porosity, mass transport properties and bioactivity resulting from densification and devitrification phenomena occurring in the material upon heating. The aim of the present work was to investigate the sinter-crystallization of a highly bioactive SiO2-P2O5-CaO–MgO–Na2O–K2O glass (47.5B composition) in reference to its suitability for the fabrication of bonelike foams. The thermal behavior of 47.5B glass particles was investigated upon sintering at different temperatures in the range of 600–850◦C by means of combined thermal analyses (differential thermal analysis (DTA) and hot-stage microscopy (HSM)). Then, XRD measurements were carried out to identify crystalline phases developed upon sintering. Finally, porous scaffolds were produced by a foam replica method in order to evaluate the effect of the sintering temperature on the mechanical properties under compression loading conditions. Assessing a relationship between mechanical properties and sintering temperature, or in other words between scaffold performance and fabrication process, is a key step towards the rationale design of optimized scaffolds for tissue repair

Light Element Abundance Patterns in the Orion Association: I) HST Observations of Boron in G-dwarfs

The boron abundances for two young solar-type members of the Orion association, BD -6 1250 and HD 294297, are derived from HST STIS spectra of the B I transition at 2496.771 A. The best-fit boron abundances for the target stars are 0.13 and 0.44 dex lower than the solar meteoritic value of log e(B)=2.78. An anticorrelation of boron and oxygen is found for Orion when these results are added to previous abundances obtained for 4 B-type stars and the G-type star BD -5 1317. An analysis of the uncertainties in the abundance calculations indicates that the observed anticorrelation is probably real. The B versus O relation observed in the Orion association does not follow the positive correlation of boron versus oxygen which is observed for the field stars with roughly solar metallicity. The observed anticorrelation can be accounted for by a simple model in which two poorly mixed components of gas (supernova ejecta and boron-enriched ambient medium) contribute to the new stars that form within the lifetime of the association. This model predicts an anticorrelation for Be as well, at least as strong as for boron.Comment: 16 pages + 1 table + 7 figures, accepted for publication in Ap

Cornell Cooperative Extension Gains Efficiencies and Increases Capacity with a Central Database

Cornell Cooperative Extension (CCE) has developed a central database system that replaces many manual processes and streamlines many other administrative procedures. The history of the Central Database Project is provided, and major accomplishments are described. These improvements have increased CCE\u27s ability to comply with state and Federal regulations and with human resources policies. Daily operations are improved with easier access to data and analysis and administrative overhead is controlled, allowing staff to focus on program development and delivery. Finally, the improved technological capacity should increase technological credibility

Chemical Evolution of the Galactic Bulge as Derived from High-Resolution Infrared Spectroscopy of K and M Red Giants

We present chemical abundances in K and M red-giant members of the Galactic bulge derived from high-resolution infrared spectra obtained with the Phoenix spectrograph on Gemini-South. The elements studied are carbon, nitrogen, oxygen, sodium, titanium, and iron. The evolution of C and N abundances in the studied red-giants show that their oxygen abundances represent the original values with which the stars were born. Oxygen is a superior element for probing the timescale of bulge chemical enrichment via [O/Fe] versus [Fe/H]. The [O/Fe]-[Fe/H] relation in the bulge does not follow the disk relation, with [O/Fe] values falling above those of the disk. Titanium also behaves similarly to oxygen with respect to iron. Based on these elevated values of [O/Fe] and [Ti/Fe] extending to large Fe abundances, it is suggested that the bulge underwent a more rapid chemical enrichment than the halo. In addition, there are declines in both [O/Fe] and [Ti/Fe] in those bulge targets with the largest Fe abundances, signifying another source affecting chemical evolution: perhaps Supernovae of Type Ia. Sodium abundances increase dramatically in the bulge with increasing metallicity, possibly reflecting the metallicity dependant yields from supernovae of Type II, although Na contamination from H-burning in intermediate mass stars cannot be ruled out.Comment: ApJ in pres

Cornell Cooperative Extension Gains Efficiencies and Increases Capacity with a Central Database

Cornell Cooperative Extension (CCE) has developed a central database system that replaces many manual processes and streamlines many other administrative procedures. The history of the Central Database Project is provided, and major accomplishments are described. These improvements have increased CCE\u27s ability to comply with state and Federal regulations and with human resources policies. Daily operations are improved with easier access to data and analysis and administrative overhead is controlled, allowing staff to focus on program development and delivery. Finally, the improved technological capacity should increase technological credibility

Dolomite-foamed bioactive silicate scaffolds for bone tissue repair

The use of three-dimensional (3D) scaffolds is recognized worldwide as a valuable biomedical approach for promoting tissue regeneration in critical-size bone defects. Over the last 50 years, bioactive glasses have been intensively investigated in a wide range of different clinical applications, from orthopedics to soft tissue healing. Bioactive glasses exhibit the unique capability to chemically bond to the host tissue and, furthermore, their processing versatility makes them very appealing due to the availability of different manufacturing techniques for the production of porous and interconnected synthetic bone grafts able to support new tissue growth over the whole duration of the treatment. As a novel contribution to the broad field of scaffold manufacturing, we report here an effective and relatively easy method to produce silicate glass-derived scaffolds by using, for the first time in the biomedical field, dolomite powder as a foaming agent for the formation of 3D bone-like porous structures. Morphological/structural features, crystallization behavior, and in vitro bioactivity in a simulated body fluid (SBF) were investigated. All the tested scaffolds were found to fulfil the minimum requirements that a scaffold for osseous repair should exhibit, including porosity (65-83 vol. %) and compressive strength (1.3-3.9 MPa) comparable to those of cancellous bone, as well as hydroxyapatite-forming ability (bioactivity). This study proves the suitability of a dolomite-foaming method for the production of potentially suitable bone grafts based on bioactive glass systems