Antimicrobial potent (E)-2-(1-phenylethylidene)-1-tosylhydrazines

399-405A series containing ten (E)-2-(1-phenylethylidene)-1-tosylhydrazines have been synthesized by thionyl chloride catalyst assisted condensation between 1-tosylhydrazine and substituted acetophenones. These benzylidenes have been characterized by their physical constants, UV-Vis, IR, 1H and 13C NMR spectral techniques. The antibacterial and antifungal activities of the synthesized benzylidene have been evaluated

Synthesis of Some Aryl Chalcones Using Silica- Sulphuric Acid Reagent under Solvent Free Conditions

Abstract: There are two series of , -unsaturated ketones derived form Biphenyl and 9H-Fluorenyl, and ketones with various substituted benzaldehydes under solvent free conditions using silica-sulphuric acid as aa reagent in an oven. The catalyst silica is reusable and the yields of chalcones are more than 90%. These chalcones are characterized by physical constants and spectral data

Synthesis of Some Aryl Chalcones Using Silica-Sulphuric Acid Reagent under Solvent Free Conditions

There are two series of α, β-unsaturated ketones derived form Biphenyl and 9H-Fluorenyl, and ketones with various substituted benzaldehydes under solvent free conditions using silica-sulphuric acid as a reagent in an oven. The catalyst silica is reusable and the yields of chalcones are more than 90%. These chalcones are characterized by physical constants and spectral data

Solvent free synthesis, spectral studies and antioxidant activities of some 6-substituted w-bromo-2-naphthyl ketones and their esters

593-604A series of 6-substituted w-bromo-2-naphthyl ketones and 6-substituted 2-naphthacyl esters have been synthesized by greener synthetic method using fly-ash:water catalyzed aqueous phase reaction.  These ketones and esters have been characterized by their physical constants, GC-MS, IR and NMR spectral data.  These compounds exist as two rotomers and the carbonyl frequencies of these rotomers have been assigned and correlated with Hammett substituent constants, F, R and Swain-Lupton’s parameters.  The antioxidant activities of the synthesized esters have been evaluated

Kinetic Studies on the Oxidation of Some para and meta-Substituted Cinnamic Acids by Pyridinium Bromochromate in the Presence of Oxalic Acid (A Co-oxidation Study)

The kinetics of oxidation of cinnamic acids by pyridinium bromochromate (PBC) in the presence of oxalic acid has been studied in acetic acid-water (60:40%) medium. The reaction shows unit order dependence each with respect to oxidant as well as oxalic acid [OX], the order with respect to [H+] and [CA] are fractional. The reaction is acid catalyzed and a low dielectric constant favours the reaction. Increase the ionic strength has no effect on the reaction rate. In the case of substituted cinnamic acids the order with respect to substrate vary depending upon the nature of the substituent present in the ring. In general, the electron withdrawing substituents retard the rate while the electron releasing substituents enhance the rate of reaction. From the kinetic data obtained the activation parameters have been computed and a suitable mechanism has been proposed

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%. These pyrazoles are characterized by their physical constants and spectral data. The infrared, NMR spectral group frequencies of these pyrazolines have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituent on the spectral frequencies have been studied. The antimicrobial activities of all synthesised pyrazolines have been studied using Bauer-Kirby method. DOI: http://dx.doi.org/10.4314/bcse.v28i2.1