83 research outputs found
The hypertoric intersection cohomology ring
We present a functorial computation of the equivariant intersection
cohomology of a hypertoric variety, and endow it with a natural ring structure.
When the hyperplane arrangement associated with the hypertoric variety is
unimodular, we show that this ring structure is induced by a ring structure on
the equivariant intersection cohomology sheaf in the equivariant derived
category. The computation is given in terms of a localization functor which
takes equivariant sheaves on a sufficiently nice stratified space to sheaves on
a poset.Comment: Significant revisions in Section 5, with several corrected proof
Degenerate flag varieties: moment graphs and Schr\"oder numbers
We study geometric and combinatorial properties of the degenerate flag
varieties of type A. These varieties are acted upon by the automorphism group
of a certain representation of a type A quiver, containing a maximal torus T.
Using the group action, we describe the moment graphs, encoding the zero- and
one-dimensional T-orbits. We also study the smooth and singular loci of the
degenerate flag varieties. We show that the Euler characteristic of the smooth
locus is equal to the large Schr\"oder number and the Poincar\'e polynomial is
given by a natural statistics counting the number of diagonal steps in a
Schr\"oder path. As an application we obtain a new combinatorial description of
the large and small Schr\"oder numbers and their q-analogues.Comment: 25 page
Persistent Intersection Homology for the Analysis of Discrete Data
Topological data analysis is becoming increasingly relevant to support the
analysis of unstructured data sets. A common assumption in data analysis is
that the data set is a sample---not necessarily a uniform one---of some
high-dimensional manifold. In such cases, persistent homology can be
successfully employed to extract features, remove noise, and compare data sets.
The underlying problems in some application domains, however, turn out to
represent multiple manifolds with different dimensions. Algebraic topology
typically analyzes such problems using intersection homology, an extension of
homology that is capable of handling configurations with singularities. In this
paper, we describe how the persistent variant of intersection homology can be
used to assist data analysis in visualization. We point out potential pitfalls
in approximating data sets with singularities and give strategies for resolving
them.Comment: Topology-based Methods in Visualization 201
Notes on factorization algebras, factorization homology and applications
These notes are an expanded version of two series of lectures given at the
winter school in mathematical physics at les Houches and at the Vietnamese
Institute for Mathematical Sciences. They are an introduction to factorization
algebras, factorization homology and some of their applications, notably for
studying -algebras. We give an account of homology theory for manifolds
(and spaces), which give invariant of manifolds but also invariant of
-algebras. We particularly emphasize the point of view of factorization
algebras (a structure originating from quantum field theory) which plays, with
respect to homology theory for manifolds, the role of sheaves with respect to
singular cohomology. We mention some applications to the study of mapping
spaces and study several examples, including some over stratified spaces.Comment: 122 pages. A few examples adde
Assessment of age-related changes in pediatric gastrointestinal solubility
PurposeCompound solubility serves as a surrogate indicator of oral biopharmaceutical performance. Between infancy and adulthood, marked compositional changes in gastrointestinal (GI) fluids occur. This study serves to assess how developmental changes in GI fluid composition affects compound solubility.MethodsSolubility assessments were conducted in vitro using biorelevant media reflective of age-specific pediatric cohorts (i.e., neonates and infants). Previously published adult media (i.e., FaSSGF, FeSSGF, FaSSIF.v2, and FeSSIF.v2) were employed as references for pediatric media development. Investigations assessing age-specific changes in GI fluid parameters (i.e., pepsin, bile acids, pH, osmolality, etc.) were collected from the literature and served to define the composition of neonatal and infant media. Solubility assessments at 37°C were conducted for seven BCS Class II compounds within the developed pediatric and reference adult media.ResultsFor six of the seven compounds investigated, solubility fell outside an 80–125% range from adult values in at least one of the developed pediatric media. This result indicates a potential for age-related alterations in oral drug performance, especially for compounds whose absorption is delimited by solubility (i.e., BCS Class II).ConclusionDevelopmental changes in GI fluid composition can result in relevant discrepancies in luminal compound solubility between children and adults.<br/
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